11β-hsd2

Long‐term magnesium supplementation improves glucocorticoid metabolism: A post‐hoc analysis of an intervention trial Joëlle C. Schutten, Peter J. Joris, Isidor Minović, Adrian Post, André P. van Beek, Martin H. de Borst, Ronald P. Mensink, Stephan J.L. Bakker First published: 08 October 2020...

Palmitic acid has a bad reputation in mainstream medical circles. It is being blamed for insulin resistance, obesity, and even triggering diabetes II. Ray has written a few times about palmitic acid, and has explained that it is one of the few known exogenous factors that can activate the enzyme...

DHEA is one of the body's primary defense mechanisms against cortisol. Not only does DHEA act like a functional anti-glucocorticoid and protect tissues but as I posted a few month ago, DHEA blocks new cortisol synthesis by inhibiting the enzyme 11β-HSD1 in micromolar concentrations, which is...

This is yet another confirmation of my suspicion that sedative substances lower cortisol levels. Niacinamide is officially recognized as a GABA-A agonist, but apparently this is not the major reason behind its effect on cortisol. The enzyme that de-activates cortisol - 11b-HSD2 - is apparently...