11β-hsd1

  1. haidut

    Palmitic Acid Inhibits Cortisol Synthesis

    Palmitic acid has a bad reputation in mainstream medical circles. It is being blamed for insulin resistance, obesity, and even triggering diabetes II. Ray has written a few times about palmitic acid, and has explained that it is one of the few known exogenous factors that can activate the enzyme...
  2. haidut

    Aspirin (salicylic Acid) Inhibits Cortisol Synthesis

    I posted several studies on aspirin and sodium salicylate being effective in reversing insulin resistance and type II diabetes in humans. However, to my knowledge the mechanism of action of aspirin and other prodrugs for salicylic acid has never been publicly elucidated even though Ray has...
  3. haidut

    Coffee Inhibits Cortisol Synthesis

    I was really pleased to see that study for two reasons. First, it gives more credibility to Peat's statement that coffee/caffeine do NOT boost cortisol, contrary to what many people claim and would like to believe. This matches well the few animal studies I have posted showing caffeine and...
  4. haidut

    Circadian Clock Dysruptions Driven By Adrenal Activity (cortisol)

    If the results of this study translate to humans then taking a little pregnenolone or progesterone (which restrain excessive cortisol release) may allow people to quickly adapt their circadian clock to a new environment as a result of long flights or working in prolonged conditions of artificial...
  5. haidut

    The Anti-cortisol Effects Of Niacinamide

    This is yet another confirmation of my suspicion that sedative substances lower cortisol levels. Niacinamide is officially recognized as a GABA-A agonist, but apparently this is not the major reason behind its effect on cortisol. The enzyme that de-activates cortisol - 11b-HSD2 - is apparently...
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