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Quotation

Pau d'Arco has the most powerful natural glyoxylase I inhibitors known: lapachol and β-lapachone. There's been dozens of studies on these two molecules, which tie-in nicely with the work of Koch and Szent-Györgyi. I would put this plant at the very top of the list, although curcumin should be the best for lower GI cancers since it basically coats the intestines. There's been a few pharmacokinetic studies demonstrating how curcumin is distributed within the body.The amino acid L-threonine will become methylglyoxal within the body (through aminoacetone intermediate), so pau d'arco with L-threonine would appear to be a safe and all-natural Szent-Györgyi-approved approach—with a Koch Seal of Approval™—to raise intracellular methylglyoxal levels. Add to this a Gerson-type diet (sans the linoleic acid-containing flaxseed oil) and you'd probably be reversing tumors in a manner similar to the lab-rats given such things.Glyoxylase I & II together turn methylglyoxal into lactic acid. Inhibiting one of these enzymes lowers intracellular lactic acid concentrations. Considering just this one enzymatic system alone, low methylglyoxal levels are synonymous with high lactic acid levels. This could help explain the findings of Otto Warburg, while linking together the apparently unrelated observations of two great biochemical Nobelists—Otto Warburg of Germany and Albert Szent-Györgyi of Hungary.The plant polyphenol baicalein appears to the most powerful glyoxylase I inhibitor among the class of polyphenols.The low-methionine diet of Gerson should be stressed, as is low in methionine; this would be expected to lead to low intracellular polyamine levelspowerful growth factors which act on DNA replication by directly stabilizing and/or uncoiling the helix. Methylglyoxal binds to, and inactivates polyamines.And limiting linoleic acid should limit excessive prostaglandins, intracellular autocrine hormones which effect DNA→mRNA transcription through the nuclear PPAR receptors.