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Quotation

if you take a meal, a fish or eat some fish oil these oxidize very quickly and form compounds that will interfere with the formation of prostaglandins, but in doing that they are also suppressing the immune system but you get temporary relief to the extent that you're overloaded with the most toxic n-6 fatty acids. So the people experience some relief of inflammation when they take fish oil but in the long run that's doing its own damage because it's so highly oxidizable.
Ray Peat, KMUD - Uses of urea