Cloudhands
Member
- Joined
- Jan 11, 2019
- Messages
- 988
Regular dmt - yesDoes anyone have experience with 5-MeO DMT ?
5meo? Nooo.
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Regular dmt - yesDoes anyone have experience with 5-MeO DMT ?
Regular dmt - yes
5meo? Nooo.
I always disliked the stomach tightness I got with LSD and mescaline.
Do anyone know any good litterature on the history of LSD and how its related to the research on serotonin?
Only LSD as far as I know blocks some ... Maybe he meant they interfere with serotonin, since they have the same skeleton as Serotonin
Mushrooms and other psychadelic trips definitely comprise two distinct phases - the first is highly emotional and self-reflective - whereas the second, or comedown/afterglow phase is very euphoric, directed and motivated. But I don't know if these two phases can be definitely reduced to just one neurotransmitter vs the other, probably its also reflecting changed activity of these signals in certain parts of the brain but not others.
If you think about dopamine is usually associated with - focus, motivation, planning, future-orientation, executive behaviour and motor coordination - its very clear these brain functions are almost completely shut off during the first phase of psychadelic trips, so it would suggest it is a low dopamine state, but probably only affecting certain parts of the dopaminergic system. The first phase is also associated with vastly reduced sensory gating (your perceptions are richer) - which is typically understood to be mediated by serotonin - ie lower sensory gating means lower serotonin. So the first phase is characterised by both lower serotonin and lower dopamine, at least in certain circuits, whereas dopamine may be increased in other parts associated with perception, whereas the second phase is more clearly a high dopamine state.
In schizophrenia, for instance, hallucinations and increased perception is associated with increased D2 receptor activity, whereas lack of motivation and reduced motor coordination/speech is associated with reduced D1 activity, and this disorder is also associated with increased mesolimbic and reduced cortical dopamine signalling, - so the first phase of psychadelic trips could result from a similar pattern of dopaminergic activity.
The emotional/self-reflective first phase seems to be necessary for the second euphoric/motivated phase though, you are more open to access and process subconscious and blocked emotions during the first phase - the resolution of which leads to a renewed feeling of freedom and sense of purpose in the second phase. The first phase puts you in a vulnerable and highly suggestible mental state akin to infancy wherein deeply buried wounds can be healed - the second phase brings you back to your adult faculties with a renewed and strengthened emotional foundation.
Yeah to be honest I find the serotonin and dopamine circuits and interactions to be too confusing to wrap my head around, so I prefer to think of various drugs in terms of their broader effects on cognition. There seems to be a clear division and reciprocal relationship between self-reflective and motivated states that are characterised by different levels of dopamine and serotonin, but these states should be in balance - motivation without self-reflection is just as bad as the reciprocal. Psychadelics will sequentially put you in both states and they should be equally embraced. Yin and Yang.
Yeah to be honest I find the serotonin and dopamine circuits and interactions to be too confusing to wrap my head around, so I prefer to think of various drugs in terms of their broader effects on cognition. There seems to be a clear division and reciprocal relationship between self-reflective and motivated states that are characterised by different levels of dopamine and serotonin, but these states should be in balance - motivation without self-reflection is just as bad as the reciprocal. Psychadelics will sequentially put you in both states and they should be equally embraced. Yin and Yang.
Not really, but for a broader perspective on the biology of dopamine and serotonin I recommend the book "The Dopaminergic Mind in Human Evolution" by Fred Previc, I think he has a more balanced view on this than Peat.Have you ever done a write up on the broader cognitive effects of drugs you deem useful/interesting?
Not really, but for a broader perspective on the biology of dopamine and serotonin I recommend the book "The Dopaminergic Mind in Human Evolution" by Fred Previc, I think he has a more balanced view on this than Peat.