The blog of Andrew Kim first alerted me to this possibility, but I recently found this study as well.
http://advances.nutrition.org/content/3/3/330.full
"...The untoward effects of vitamin E supplements on blood clotting may result from vitamin E and K interactions because these supplements increase undercarboxylation of prothrombin, suggesting lower vitamin K activity. More than 90% of dietary, plant-derived vitamin K is phylloquinone (vitamin K1) with a 20-carbon phytyl side chain that is identical to that of tocopherol. Phylloquinone is converted to menadione and then to MK-4 (extrahepatic tissue vitamin K). Based on their similar structures, vitamins E and K likely share the same pathways for metabolism and excretion. Possible mechanisms for the vitamin E and K interaction have been proposed, but none have been proven. "
As for myself, when taken with enough fat, both vitamins give me a similar energy "boost", and both sedate me a bit at high doses (800IU+ of tocopherols, or 30mg+ of MK-4).
http://advances.nutrition.org/content/3/3/330.full
"...The untoward effects of vitamin E supplements on blood clotting may result from vitamin E and K interactions because these supplements increase undercarboxylation of prothrombin, suggesting lower vitamin K activity. More than 90% of dietary, plant-derived vitamin K is phylloquinone (vitamin K1) with a 20-carbon phytyl side chain that is identical to that of tocopherol. Phylloquinone is converted to menadione and then to MK-4 (extrahepatic tissue vitamin K). Based on their similar structures, vitamins E and K likely share the same pathways for metabolism and excretion. Possible mechanisms for the vitamin E and K interaction have been proposed, but none have been proven. "
As for myself, when taken with enough fat, both vitamins give me a similar energy "boost", and both sedate me a bit at high doses (800IU+ of tocopherols, or 30mg+ of MK-4).
