Metabolic Compound Could Rewind Fertility Clock For Women (Niacin)

Ras

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On the new study, researchers linked a specific molecule to the loss of egg quality in mice. They found that as mice age, it’s accompanied by declining levels of nicotinamide adenine dinucleotide (NAD+), which is important for metabolism. That in turn affects the quality of remaining eggs, leading to fertility problems in older female mice.

So, the team investigated how this molecule could be restored, and whether that might help delay or even reverse infertility. They gave the mice oral doses of a precursor compound called nicotinamide mononucleotide (NMN). Cells use NMN to produce NAD+, so raising levels of the precursor should help increase NAD+ levels and, by extension, improve fertility. And it appeared to work in the mice.
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