i am dosing very conservatively. but it's a combination:
estroban 4-7 drops most mornings orally
androsterone 1 drop orally anytime stressful situations arise (10-15 1-drop doses per week)
kuinone 3-5 drops on balls, 1x per day
tyromax 7 drops (about 1 grain) on balls, 1x per day
I take 3 grains of NDT and approx 12-20 micrograms of T3 sublingually per day...and have been on this for one year, very gradually increasing dose based on body temp and heartbeat primarily. Anytime I put tyromax on the balls, I reduce oral dose of NDT by same amount so total stays constant. It was in this context that made it so surprising that when just shifting one grain of NDT from oral to tyromax on balls--in combination with kuinone--made me feel unusually well, morning wood and multiple erections per day. That is feeling "back to normal" to me.
I haven't tried T3 by itself topically, just NDT in tyromax. If other things are going wrong metabolically, then too much oral T3 can give some reverse T3 symptoms possibly...but that's pretty hard to recognize what spiking rT3 feels like. Mostly oral T3 has been great for me. It works as an energizer, a mild antidepressant and a great way to deal with high-carb meals with dairy, which prevents the T4 in NDT from being absorbed orally (i.e. prevents me from taking the oral NDT dose). Applying tyromax to the balls for me was discovered by accident. I just used it as a crutch when I first got it 4-5 months ago. I was having so much dairy that I couldn't find a good time to take my NDT oral dosing, which led me to put seven drops of tyromax on balls in lieu of one grain oral NDT. Within hours and next day, there were more and harder erections.
I have noticed morning wood and firmer erections during intercourse with just kuinone applied to balls. In fact I'd really start with kuinone as first-line put-it-on-your-balls experiment. I started 3 months ago just with kuinone just after discovering the tyromax effect. Kuinone is the most reliable and easy to use put-it-on-your-balls supplement for me.
I do think that if you're trying to suppress stress hormones (adrenalin/cortisol/prolactin/estrogen) that there are times when successful suppression leads to an empty feeling and reduced sex drive, no morning wood. It was in this context that i recently (last month) began experimenting with pansterone. I've had incredibly good honeymoons with preg and bad burnouts with it, too. And oral DHEA never made me feel anything but terrible, like estrogenic stress storm--a singularly awful feel. But that was probably because so many other things were running on stress hormones at that time for me. I've had 15 successful 5-drops of pansterone on balls experiments following gym workouts in last two weeks. Success for me means I feel warm, confident and sexually potent afterwards and in the morning after. And I've had two misses, too, where I think once again i got some estrogenic stress storm. But treating it with more estroban and then trying again led to success. Just small doses.
So i occasionally add the 5 drops of pansterone to kuinone and tyromax on balls for a triple application. But i've had noticeable and always positive results with kuinone, almost always good and often more powerful positive results with kuinone + tyromax (5 drops and 7 drops), and sometimes the most potent effects where I see behavioral effects and effects in the gym of obviously elevated Testosterone (I think--no blood work to report) from the triple application with pansterone at a moderate dose of 5 or 8 drops max on balls which synergizes I think with the one drop androsterone orally i will have likely had too.
This sounds jumbled, I know, but I've tried to be fairly methodical and experiment with one at a time, then two, then three. I think I understand how these supplements are working in my body now well enough to be confident to continue this way. 3-4 months like this and I feel like a much younger and more energetic person.
Thanks for the thorough reply. That's a lot of T3!
As I said before, Kuinone on scrotum is the one supplement I have enjoyed quite reliably (I psoted on the kuinone thread too). I guess I'm just quite conservative in my approach : dmso half life, its potential effects on progesterone and star protein as well as acetycholine, and the simple fact that I think the body is pretty smart and adapts to most substance over time. That being said I don't have first hand experience over that. I'd retry the T3 on scrotum if I could dilute it easily, when I tried it I did too much (one and two drops of tyronene).
I guess one of the questions is if you had to stop (whatever the reason, haidut can't sell the same product anymore etc...) would you feel worst than before for some time or not.
An other issue I have with those supplements is that they shift the emphasis away from diet, I have experienced very different things with different meals but supplements can make up for what is actually not an optimal diet.
Thanks, that one was mentioned before, I don't know if this applies to dhea but it could given they mention 5-alpha-reductase activity in the skin as a reason for the increase in dht. I wonder why people get estrogenic side effects from dhea though, perhaps focusing on skin areas where 5-alpha-reductase is more important would help.I found a relatively new study talking about using a Testosterone supplement on the scrotum.
Pharmacokinetics of testosterone cream applied to scrotal skin. - PubMed - NCBI
"... scrotal skin is advantageous for transdermal testosterone delivery as it has the thinnest stratum corneum (Smith et al., 1961; Ya-Xian et al., 1999), high steroid permeability (Wester & Maibach, 1989) many times greater than non-scrotal skin (Lin et al., 1999), and minimizes the risk of passive topical transfer to others."
"The bioavailability of testosterone via the scrotal skin is striking higher than for abdominal skin. Using the same testosterone cream and steroid LC-MS assay measurements, in this study a Cmax (4.6 ng/mL, 16.0 nM) was achieved with the lowest dose (12.5 mg) applied to the scrotal skin whereas applying 100 mg
testosterone cream to the abdominal skin produced a Cmax of 16.3 nmol/L (4.7 ng/mL). This suggests an about eightfold increase in testosterone bioavailability, using the scrotal compared with abdominal skin routes."
"Disproportionate increases in serum DHT are reported after administration of all transdermal testosterone products with the higher DHT/T ratio attributable to the strong expression of 5-alpha reductase in skin structures which foster the conversion of testosterone to DHT during transdermal passage. Furthermore
androgens induce greater expression of the 5a reductase enzyme whereby administration of an androgen directly onto the skin creates a feed-forward (positive feedback) mechanism (Russell & Wilson, 1994; McNamara et al., 2013)."
"The clinical significance of such increased DHT/T ratio, common to all non-parenteral routes of testosterone administration, is doubtful as studies
maintained circulating DHT levels of 10 times the physiological concentrations for up to 2 years without increasing prostate size or growth or any adverse sequelae (Idan et al., 2010) nor do exogenous androgens increase intraprostatic DHT (Marks et al., 2006; Page et al., 2011; Mostaghel et al., 2012; Thirumalai
et al., 2016)."
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I wonder if something like 11-keto-testosterone would follow the same steps and create a positive feedback mechanism (up regulate 5-alpha reductase), I don't remember if 11-keto-testosterone is affected by 5-alpha reductase.
Lol that would be a bummer.Also, if any of you have kids in the next 10 years, please report back with any anomalies
@T-3 If you have some estroban at hand would you mind trying it on scrotum and report? I did not think about it when I had some and now I'm broke..