Apigenin Increases Steroidogenesis

[Inaut]

was just doing some reading after your post @Obi-wan . It seems autophagy is beneficial in some cancers and contraindicated in others. It's so hard to get a firm sense of what's really going on with cancer cells.....whatever happened to magic bullets or things being easy???

 

[Obi-wan]

was just doing some reading after your post @Obi-wan . It seems autophagy is beneficial in some cancers and contraindicated in others. It's so hard to get a firm sense of what's really going on with cancer cells.....whatever happened to magic bullets or things being easy???

Autophagy is cancer cells picking up the debris of other liced cancer cells and using this debris in making daughter cells. Cancer is like an alien inside of us. That's why attacking the metabolics of it is the answer. If you can't beat it starve it to death...

 

[shine]

"Previous studies reported that the age-related decline in testosterone biosynthesis is associated with a decrease in the steroidogenic acute regulatory (StAR) protein which regulates the rate-limiting step of testosterone biosynthesis. To explore the possibility of delaying this decline using a dietary approach, we have examined the effect of a natural flavonoid, apigenin, on StAR gene expression in mouse Leydig cells. Incubation of these cells with the flavonoid enhanced cyclic adenosine monophosphate (cAMP)-induced steroidogenesis and StAR protein expression. The results from the analyses of StAR mRNA by reverse transcription-polymerase chain reaction and the luciferase assays of StAR promoter activity indicated that this flavonoid enhanced StAR gene expression at the level of transcription. Further studies showed that apigenin blocked the thromboxane A2 receptor and interrupted the signaling through the cyclooxygenase-2-thromboxane A synthase-thromboxane A2-receptor pathway, resulting in a reduction of DAX-1 (dosage sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene-1) protein, a transcriptional repressor of StAR gene expression. When DAX-1 protein was reduced, the sensitivity of the Leydig cells was dramatically enhanced, with sub-threshold level of cAMP being able to induce maximal levels of StAR protein expression and steroid hormone production. The present study suggests a potential application of apigenin to improve StAR protein expression and steroidogenic sensitivity of aging Leydig cells."

Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. - PubMed - NCBI

Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. - PubMed - NCBI


Upregulates StAR and cAMP but downregulates steroidogenic enzymes?!

 

[Broken man]

Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. - PubMed - NCBI


Upregulates StAR and cAMP but downregulates steroidogenic enzymes?!

Fck Ye, I thought that I will use parsley every day but I dont know Now....

 

[Dave Clark]

Does apigenin have basically the same benefits or side effects as luteolin or narigenin ?

 

[High_Prob]

Here is another study that shows that it may inhibit steroidogenic enzymes (5α-reductase 1 and 3α-hydroxysteroid dehydrogenase):

Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase - PubMed

Apigenin, a common flavonoid, has extensive pharmacological activities. Apigenin inhibits some steroid biosynthetic enzymes, suggesting that it may block neurosteroid synthesis. Neurosteroids play many important roles in neurological functions. The objective of the present study is to...

pubmed.ncbi.nlm.nih.gov

Abstract​

Apigenin, a common flavonoid, has extensive pharmacological activities. Apigenin inhibits some steroid biosynthetic enzymes, suggesting that it may block neurosteroid synthesis. Neurosteroids play many important roles in neurological functions. The objective of the present study is to investigate effects of apigenin on neurosteroidogenic enzymes, 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RoDH2), in rats. SRD5A1, AKR1C9, and RoDH2 were expressed in COS-1 cells and the effects of apigenin on these enzymes and modes of action were explored using radiolabeled substrates and thin-layer chromatographic separation coupled with radiometry. Apigenin inhibited SRD5A1, AKR1C9, and RoDH2 activities with IC50 values of 100, 0.891 ± 0.065, and >100 μM, respectively. Apigenin competitively inhibited rat AKR1C9 when its substrate 5α-dihydrotestosterone was used and uncompetitively inhibited the enzyme when cofactor NADPH was used. In conclusion, apigenin is a potent inhibitor of rat AKR1C9, thereby controlling the rate of neurosteroid biosynthesis.

 

[CastorTroy]

Here is another study that shows that it may inhibit steroidogenic enzymes (5α-reductase 1 and 3α-hydroxysteroid dehydrogenase):

Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase - PubMed

Apigenin, a common flavonoid, has extensive pharmacological activities. Apigenin inhibits some steroid biosynthetic enzymes, suggesting that it may block neurosteroid synthesis. Neurosteroids play many important roles in neurological functions. The objective of the present study is to...

pubmed.ncbi.nlm.nih.gov

Abstract​

Apigenin, a common flavonoid, has extensive pharmacological activities. Apigenin inhibits some steroid biosynthetic enzymes, suggesting that it may block neurosteroid synthesis. Neurosteroids play many important roles in neurological functions. The objective of the present study is to investigate effects of apigenin on neurosteroidogenic enzymes, 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RoDH2), in rats. SRD5A1, AKR1C9, and RoDH2 were expressed in COS-1 cells and the effects of apigenin on these enzymes and modes of action were explored using radiolabeled substrates and thin-layer chromatographic separation coupled with radiometry. Apigenin inhibited SRD5A1, AKR1C9, and RoDH2 activities with IC50 values of 100, 0.891 ± 0.065, and >100 μM, respectively. Apigenin competitively inhibited rat AKR1C9 when its substrate 5α-dihydrotestosterone was used and uncompetitively inhibited the enzyme when cofactor NADPH was used. In conclusion, apigenin is a potent inhibitor of rat AKR1C9, thereby controlling the rate of neurosteroid biosynthesis.

I don't know to what extent is this inhibition relevant. Lauric acid, the major component in coconut oil, in an inhibitor also.

https://onlinelibrary.wiley.com/doi/10.1002/cbdv.200800125

 

[ddjd]

What other supplements increase StAR (Steroidogenic acute regulatory protein)????