I know this probably isn't the most 'Peat Friendly' substance in the world, and this thread may even be one for the shroomery. Nonetheless, I've experimented two times this week with Ketamine and I have to say it has had a positive impact on my mood.
I found myself to be much more open minded and positive the day after its use, almost like I've had a mini holiday from it all.
Obviously you're all probably more well read than I am, as to why i'm interested what your thoughts are on Ketamine?
Ketamine for depression
Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial. - PubMed - NCBI
"ketamine demonstrated a greater reduction in clinically significant suicidal ideation in depressed patients "
Intravenous ketamine infusion for a patient with treatment-resistant major depression: a 10-month follow-up. - PubMed - NCBI
"Her mood stabilized, and she showed a nearly 50% reduction in the severity of her depressive symptom."
The rapid-onset antidepressant effect of ketamine: More surprises? - PubMed - NCBI
"inhibition of the NMDA subtype of glutamate receptor"
Peaty am I right?
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine. - PubMed - NCBI
"ketamine (20 mg/kg) showed an antidepressant effect in the rat learned helplessness model."
Helping with learned helplessness?
Personal Experience:
The second time I did Ketamine, was the most profound, I did it intranasally, I don't know how much but wasn't enough to K-hole, nonetheless quite a substantial amount. My vision became very blurred, like being kind of drunk, I spent my time high listening to music on my bed closing my eyes, I had closed eye visuals of rotating glass bottles, people dancing in neon lights, reminiscent scenes of childhood memories which were very vivid, so much so that I picked out details that I hadn't realised since these events had happened.
I felt quite relaxed and floaty on the Ketamine. Certainly an interesting and mind opening experience.
I found myself to be much more open minded and positive the day after its use, almost like I've had a mini holiday from it all.
Obviously you're all probably more well read than I am, as to why i'm interested what your thoughts are on Ketamine?
Ketamine for depression
Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial. - PubMed - NCBI
"ketamine demonstrated a greater reduction in clinically significant suicidal ideation in depressed patients "
Intravenous ketamine infusion for a patient with treatment-resistant major depression: a 10-month follow-up. - PubMed - NCBI
"Her mood stabilized, and she showed a nearly 50% reduction in the severity of her depressive symptom."
The rapid-onset antidepressant effect of ketamine: More surprises? - PubMed - NCBI
"inhibition of the NMDA subtype of glutamate receptor"
Peaty am I right?
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine. - PubMed - NCBI
"ketamine (20 mg/kg) showed an antidepressant effect in the rat learned helplessness model."
Helping with learned helplessness?
Personal Experience:
The second time I did Ketamine, was the most profound, I did it intranasally, I don't know how much but wasn't enough to K-hole, nonetheless quite a substantial amount. My vision became very blurred, like being kind of drunk, I spent my time high listening to music on my bed closing my eyes, I had closed eye visuals of rotating glass bottles, people dancing in neon lights, reminiscent scenes of childhood memories which were very vivid, so much so that I picked out details that I hadn't realised since these events had happened.
I felt quite relaxed and floaty on the Ketamine. Certainly an interesting and mind opening experience.
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