Hats Off To Harry Rubin And Gershon Zajicek, Cancer Hypothesis

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Ray mentions him. Dr. Rubin is a veterinarian who researches and still seems active. He must be 90 years old.

I think he should have gotten a Nobel.

He found that some viruses cause cancer. He found out how some viruses BLOCK these cancer-causing viruses similar to how cowpox apparently blocks smallpox. And he found out how cancer tissues in contact with healthy tissues become non-cancerous, and vice versa.

He has recently been studying how magnesium deficiency contributes to carcinogenesis.

I think his idea of cancer is quite epigenetic. Inflammation causes many epigenetic changes in a given organ's cells, and some of these changes are bad ones. These bad changes can eventually overwhelm the healthy cells ability to keep the bad cells in check, and the bad cells eventually become a tumor.

Dr. Gershon Zajicek also has influenced Dr. Peat.

Dr. Zajiceck believes cancer starts with a virus, chronic inflammation and viremia, and this leads to the "cancer field".

Both researchers believe similarly but Zajicek believes more that the virus can be stopped, and that will stop cancer's progression.

However, Zajicek says that the longer we live with a tumor, the more our host defences keep it under control, and that cancer is just another type of cell in the body that we learn to live with. Cancer is a "new life" for us but we don't try to get rid of it, we just live with it, and try to be strong.

People seldom die of cancer but often die from cancer TREATMENTs and their death is not attributed correctly.

Most of the cancer treatments nowadays are very expensive and not proven to work, but they are allowed to be offered because they somehow satisfy the desire for a positive "surrogate endpoint" prior to death.
 

Tenacity

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I remember reading recently that Rubin believed cancer preceded genetic mutations. A study was published just last week claiming the opposite, that different cancers requite different number of mutations to occur. It'll be a long time before the dogma on genetics gives way to more holisitic cancer treatments.
 
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ecstatichamster
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I remember reading recently that Rubin believed cancer preceded genetic mutations. A study was published just last week claiming the opposite, that different cancers requite different number of mutations to occur. It'll be a long time before the dogma on genetics gives way to more holisitic cancer treatments.

That had been the pet theory. I think it is probably wrong. Rubin disproved the somatic mutation theory.
 

TreasureVibe

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He has recently been studying how magnesium deficiency contributes to carcinogenesis.

This implies nutritional deficiencies as a cause of cancer. How about nitrogen deficiency? Cancer tumors all have what is known as a "nitrogen trap". If cancer is a fungus, then check this out:

Published october 2017
Ammonia is a ubiquitous by-product of cellular metabolism, however the biological consequences of ammonia production are not fully understood, especially in cancer. We find that ammonia is not merely a toxic waste product, but is recycled into central amino acid metabolism to maximize nitrogen utilization. Cancer cells primarily assimilated ammonia through reductive amination catalyzed by glutamate dehydrogenase (GDH), and secondary reactions enabled other amino acids, such as proline and aspartate, to directly acquire this nitrogen. Metabolic recycling of ammonia accelerated proliferation of breast cancer. In mice, ammonia accumulated in the tumor microenvironment, and was used directly to generate amino acids through GDH activity. These data show that ammonia not only is a secreted waste product, but a fundamental nitrogen source that can support tumor biomass.
Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

Diploid S. cerevisiae strains undergo a dimorphic transition that involves changes in cell shape and the pattern of cell division and results in invasive filamentous growth in response to starvation for nitrogen. Cells become long and thin and form pseudohyphae that grow away from the colony and invade the agar medium. Pseudohyphal growth allows yeast cells to forage for nutrients. Pseudohyphal growth requires the polar budding pattern of a/alpha diploid cells; haploid axially budding cells of identical genotype cannot undergo this dimorphic transition. Constitutive activation of RAS2 or mutation of SHR3, a gene required for amino acid uptake, enhance the pseudohyphal phenotype; a dominant mutation in RSR1/BUD1 that causes random budding suppresses pseudohyphal growth.
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. - PubMed - NCBI

The effect of nitrogen sources including yeast extract, peptone, soybean hydrolyzate and some inorganic nitrogen sources, as well as the nitrogen concentration on the fermentative production of pyruvate by Torulopsis glabrata WSH-IP12 was investigated. The addition of yeast extract greatly inhibited pyruvate accumulation, while peptone was shown to be the most favorable nitrogen source. In flask culture, 15 g l(-1) peptone was needed to consume 80 g l(-1) glucose with 23.4 g l(-1)of pyruvate accumulated. Pyruvate production was markedly dependent on the ratio of carbon to nitrogen (C:N), its production was improved by increasing the concentration of glucose and peptone proportionally and reduced by exclusively increasing the glucose concentration. In a glucose fed-batch culture, cell growth and pyruvate production slowed after 28 h. However, cell growth and pyruvate production recovered after further nitrogen, in the form of peptone and ammonium sulfate, was added to the culture. A final concentration of pyruvate of 54.5 g l(-1) was achieved at 64 h (yield to glucose consumed of 0.471 g g(-l)). By using aqueous ammonia instead of potassium hydroxide for pH control, 57.3 g l(-1) pyruvate with a yield of 0.498 g g(-1) was produced by 55 h. This result further indicates that nitrogen level plays an important role in the production of pyruvate.
Effect of nitrogen source and nitrogen concentration on the production of pyruvate by Torulopsis glabrata. - PubMed - NCBI
 

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