I was watching a video of Chris Masterjohn, where he points out that he doesn't believe in anti-inflammatory drugs because that they not only inhibit the initiating of inflammation but also inhibit resolving inflammation (from 14:15):
Are you guys familiar with this point of view? And do you guys have an opinion about this?
He specifically points to the COX inhibitors, and points out that high dose fish oil is in fact not acting very different than a COX inhibitor. He says that AA and the action of COX on AA is crucial to resolving inflammation, and that inhibiting this process can make inflammation become chronic.
I guess that this doesn't necessarily interferes with Ray Peat's recommendations. He recommends against high dose fish oils. The anti inflammatory aspirin he recommends, is not a strong inhibitor of COX in vivo. And eating egg yolks on a daily basis would make it pretty impossible to become deficient in AA.
I'm aware of the idea that mead acid could replace the role of AA in the COX metabolism, but I think this argument is for most people purely theoretical. Because in the natural diet, where you consume non hydrogenated coconut oil, butter, seafood and egg yolks, it seems pretty much impossible to deplete your body from AA (or the other fatty acids that metabolise to AA).
So the question remains then, is the action of COX on AA crucial to resolving inflammation and could inhibiting this process make inflammation become chronic?
Tagging @haidut as he seems to have studied AA metabolism in detail. I have also emailed Ray Peat the same question.
Are you guys familiar with this point of view? And do you guys have an opinion about this?
He specifically points to the COX inhibitors, and points out that high dose fish oil is in fact not acting very different than a COX inhibitor. He says that AA and the action of COX on AA is crucial to resolving inflammation, and that inhibiting this process can make inflammation become chronic.
I guess that this doesn't necessarily interferes with Ray Peat's recommendations. He recommends against high dose fish oils. The anti inflammatory aspirin he recommends, is not a strong inhibitor of COX in vivo. And eating egg yolks on a daily basis would make it pretty impossible to become deficient in AA.
I'm aware of the idea that mead acid could replace the role of AA in the COX metabolism, but I think this argument is for most people purely theoretical. Because in the natural diet, where you consume non hydrogenated coconut oil, butter, seafood and egg yolks, it seems pretty much impossible to deplete your body from AA (or the other fatty acids that metabolise to AA).
So the question remains then, is the action of COX on AA crucial to resolving inflammation and could inhibiting this process make inflammation become chronic?
Tagging @haidut as he seems to have studied AA metabolism in detail. I have also emailed Ray Peat the same question.