Peatish Eyedrops

Ella

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I was really horrified to read what the initially innocuous sounding eyedrops were likely to be based on: adrenergics, beta blockers and prostaglandins! for starters. And their preservatives.

Precisely SQu, exactly what my research reveals. Disease does not just fall out of the sky. Or you have perfect eyes one month and boom a derelict gene gets turn on and your cornea thins. There needs to be that perfect planetary alignment, where a set of variables come into play and boom a perfect storm.

Contacts are being worn for fashion, why the hell would you want to wear them if you have perfect vision - boogles the mind.

The following is an article as SQu mentioned is on vasoconstrictors. Anyone use murine. Pissing in the eye does the trick.

https://www.reviewofophthalmology.com/article/vasoconstrictors-myths-and-realities

MB is a photosensitiser so you need to be extremely careful if you are thinking of using it for dry eye conditions. This is completely wrong thinking. Let me explain. First, you need to understand that in dry eye condition, it is lack of tear film that coats the cornea that is the problem. When there is a lack of this tear film, the corneal cells are subjected to increased oxidative stress and increased organic peroxides that need to be neutralised. So compared to normal corneas, dry cornea are subjected to increase reactive oxygen species.

Methylene blue is a photosensitizer used to create singlet oxygen when exposed to both oxygen and light. It is used in this regard to make organic peroxides by a Diels-Alder reaction which is spin forbidden with normal atmospheric triplet oxygen.

So methylene blue will create more ROS (just from normal oxygen) to an already overburdened and exhausted corneal tissue that is dealing with ROS. You need to increase the tear film and the tear film needs to be nutrient rich to neutralise the deleterious reactive molecules. You do not want to add my fuel to the fire!!!

Fungal keratitis: Rapid diagnosis using methylene blue stain

I provide the attached file on methylene blue, to caution when experimenting with the eyes. You can experiment on your dog, cat or rabbits eyes but be extremely careful when it comes to your own eyes. If you are wearing contacts, then you have no idea what is breeding on the surface or just below the surface of the cornea. Many people have ulcers and may not even be aware of these. I like to work with biological substances rather than nasty chemicals. Nature is much more clever and sophisticated and industrial chemical. Why even urine offers many beneficial molecules that get flushed down the toilet every day. I would do organic raw milk as milk has loads of beneficial molecules. Autologous serum is excellent for dry eyes has shown to improve tear film and slow breakdown time. It would be expensive to have a dr to do it for you, but if you are game to do your own blood draws, then it is far superior - it is your own biological fluid. You are less likely to reaction to your own body fluids. It is not hard to do, spin it down and take the serum off. Place into tiny vials and freeze. Take out as needed and apply to the cornea. If you know anyone that is expecting a baby, then plead with them to keep the placenta for you. You can cut it up into pieces, freeze and apply on the eye, like a band-aid. It has wonderful healthy properties.

Used in Eye Surgery to Help Damaged Eye Surfaces Heal Faster | AmnioGraft®

The beauty of having your own animals is that you can easily have access to the placental tissue after lambing. You don't have to harass pregnant women who these days are likely to eat it for nourishment.

Now if you are really game, there is raw liver juice. In fact, just placing the liver over your eyes and then eating it works well too. I think I prefer having liver juice in my rather than raw liver sitting on my face. The ancients worked out the benefit of liver which kinda makes us look stupid. There are many options including honey than having to resort to MB. Always put yourself in your cells shoes and think about what they would like. Work with them instead of against them.

Night Blindness and Ancient Remedy

How many of you eat regular liver and oysters?

MB is use to treat bacterial and fungal infections in fish.

Ophthalmology of Exotic Pets

Read on adverse reactions and contra-indications at the following link.

Clinical Ocular Pharmacology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707430/

The following paper provides clues on how well MB penetrates corneal layers. Also demonstrates an excellent technique in drug delivery into the corneal layers. I am not advocating you explore this with MB.

http://www.sciencedirect.com/science/article/pii/S0928098716301749

The following is a step by step on how to make your own autologous serum. Read thoroughly and be extremely scrupoulos in preventing microbial contamination. The setup cost should not be too expensive when you consider what you would pay to have a specialist do it. Remember, you need to be meticulous - not slap dash with infection control.

https://www.reviewofoptometry.com/article/how-and-why-to-make-autologous-serum
 

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LeeLemonoil

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Thanks once again @Ella, invalubale info!
I'll figure I can produce autologous serums with my current lab-setup already, will report when I start an attempt ometime lter this year. Should provide good info to others interested
 

Ella

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Remember, the quality of the serum is only as good as the energetics of the individual. Trials were done with KC and results were variable. The quality of the serum is crucial, which means the health and energy of the person are of the essence. So optimise thyroid hormones and make sure you address deficiencies. Bring everything up to optimal. This way your serum will be excellent and don't forget niacinamide if you are currently not using it.

If you already have your lab in place, perhaps you can source a secondhand topography imagery equipment to track changes. I would certainly be interested in the images. I think this will be indispensable if supplementing hormones. I see the biggest changes in corneas with hormones replacement therapies and contact lens wear. Hormones have a huge impact on the cornea.

Even if you are unable to track, the serum should provide relief from the discomfort of contact lens and provide nourishment to the cornea. Safer than any of the alternatives out there.

Remember to be scrupulous with infection control.
 

Beehelp

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Has anyone tried home-made drops with honey? I would appreciate the recipe)
 

tara

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Hi @Ella
If making one's one eye drops with clean water and saline and honey or sucrose, what proportions would you recommend? I'm getting occasionally dry, gravelly, and sometimes bloodshot eyes and bought what the pharmacist recommended recently, but if there is a safer/better option I can easily make up myself I'm interested.
Thanks
 
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LeeLemonoil

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Some update:

Niacinamide has quite some serious reports of causing dry eyes even when used systemically - I will abstain from using it in eyedrops.

I still have very good results with slf-made eyedrops containing 0,9% NaCl injection-water (autoclaved) with 3% Ecton and 0,3-0,5% Hyaluronic acid.

I have made a small bottle of the same mix, but added 1% MagChloride flakes per weight - I'm curious if MagChloride will "feel" helpful but I think quantity should be kept low - since my selfmade drops are selfmade and unpreserved, whicj is not without risk of infection, I also hope that MgCl will offer some bacteriostatical benefits to the solution.

An altrnative to Manuka honey is probably organic Lavender-honey which is produced in the Provence and other places in Europe, for european users. It's very mild and lavender has some history for soothing eye-problems.

Xylitol could be another compound worth looking into for soothing and bacteriostatic properties
 

JDD

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BUMP. Anyone have good peatish eye drops they are using? I'm developing surfer's eye/pterygium and think some good eye drops post surf could help.
 
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LeeLemonoil

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After 3 weeks of Doxycyclin 200mg use to prevent borreliosis after a tick bite, I look into the role of the microbiome of the eye tissue matrix again.

My eyes were very bloodshot and dry after about 1 week and returned to normal, unirritated state again about 1 week after stopping to thake the antibiotics. Also, the sides of my nose got sun-burned while on Doxy, which never happens normally. L. Reuterii and B. Longum (among others probably) are known to be involved in UV-protection in skin-tissue, so reducing those beneficial strains while on doxy seems to predispose for sunburns - similar actions might occur within the eye. It's hard to tell if microbiotic eyedrops are promising therapeutic agent for eye-issues, since so litte is known about the beneficial strains or the interaction of adding isolated, presumably beneficial strains to an existing microbiom.

@Ella is well versed in the immunological matters of the cornea, would be great to read her assesment.

On another note, since Peat himself suggested topical T3-drops in one of his articles and this recent discussion
Action Of Topical Thyroid Hormone Analogue In Reversing Glucocorticoid-induced Skin Atrophy

eyedrops containing T3 might be promising for serious conditions or general corneal health. If T3 can reverse Glucocorticid-induced damage in the skin, it might alleviate tissue damages in the cornea caused by similar catabolic stressors (excitatory stress/NMDA, MMPs and so forth)

Probably T2 would be even better suited.
 
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LeeLemonoil

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A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes

A Pilot Study: The Efficacy of Virgin Coconut Oil as Ocular Rewetting Agent on Rabbit Eyes

Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits. Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes in all the measurable variables over the period of time. Results. Only conjunctival redness with instillation of saline agent showed significant difference over the period of time (P < 0.05). However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P > 0.05). There were no changes in the NIBUT, limbal redness, palpebral conjunctiva redness, corneal staining, pH, and Schirmer value over the period of time for each agent (P > 0.05). Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

and someone who elaborates on the study:
Coconut Oil: The Top Natural Eye Lubricant
 
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LeeLemonoil

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A synthetic "plastoquinone" called sKQ1, sees application in eyedrops in Russia. It's an antioxidant that targets the mitochindria and accumulates there. I've not yet found the time to study the MoA and if it is in line with our/Peatish understanding of what constitutes metabolic and mitochondrial health, but Quinone and Russian science always merits a deeper look.

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns visi... - PubMed - NCBI
https://www.news-medical.net/news/20160512/Scientist
https://cosmicnootropic.com/product...fy-molecular-mechanism-of-Visomitin-drug.aspx
https://mitochondrialdiseasenews.com/tag/visomitin/
Preventive and therapeutic effects of SkQ1-containing Visomitin eye drops against light-induced retinal degeneration. - PubMed - NCBI
 
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LeeLemonoil

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Brand New Ray Peat-inspired Skincare Product Now Available!

Given the highly beneficial effects of topical cholesterol on skin outlined by the studies referenced in that thread, and the proven effctivity of lanosterol and cholesterol-oxides for some eye-conditions, I'd wager that topical cholesterol would have soothing and protective effects when applied on the eye during some conditions or jsut to increase UV-resistance.

Some lightly oily eye-potion with cholesterol would be interesting
 
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LeeLemonoil

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I've pondered using Aloe Vera Gel as a n eye lubricant, due to its many intersteing components (polysaccharides, sterols) and purpotedly androgenic plant-hormones Gibberrelin and Auxin.
Unfortunately, the data for Gibberrelin and Auxin is contradictory and I dont know if these compounds are in AV-gel in sufficient amounts to have an effect.
Also, AV-Gel is acicidic (ph 4,5) and stings quite a lot, I've tested it. It is perhaps also much more estrogenic than widely assumed:

http://egyptianjournal.xyz/60_2.pdf



Revisting Methylene Blue:
Methylene Blue For Skin Health

That study shows a range of great benefits for skin-health at concentrations of 2,5 microMol concetrations. This is an incredibly tiny amount and is still orders of magnitude smaller than what these eyedrops use:
http://www.kahira-pharma.com/products/pdf/Prisoline_blue_E.Drops.pdf

3mg per 100ml is ~93 microMol.

@Ella
made a good case against MB use on the cornea, but I wonder if these small concetrations would show the same tissue-healing and regenerating benefits that were presented in the nature study on skin healht.
 
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LeeLemonoil

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https://www.ncbi.nlm.nih.gov/m/pubmed/18848318/

That study compares Eyedrops containing Vitamin A with drops containing Cyclosporine, a powerful immunsuppresant that is used in eyecare to treat e.g. sever blepharitis or conjunctivits ... inflammatory conditions that are
resistant to more conventional treatments.
The study concludes Vit A is as effective.

@haidut
This is an interesting find, another proof for how powerful and versatile a substance Vitamin A is
 

haidut

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LeeLemonoil

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http://eyecro.com/formulation-services/eye-drop-formulations/


The topical delivery of compounds into the eye with a suitable eyedrop formulation is the ideal route of administration as it is non-invasive, doses can be easily tailored, and is unlikely to affect other organs due to a low amount of systemic drug exposure. While eyedrop formulations have been classically used to deliver soluble molecules to the anterior segment, there is a strong desire to develop formulations which can deliver lipophilic molecules into the eye by means of a stable and comfortable eyedrop formulation. EyeCRO has developed a custom library of thermodynamically stable micro-emulsions which can solubilize very hydrophobic small molecules and deliver them in abundant quantities to both the anterior segment and posterior segment. Substantial proof of concept for delivery, efficacy, and safety has been demonstrated with multiple APIs in mice, rats, rabbits, and non-human primates.
 
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LeeLemonoil

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seems those microemulsions are effective in delievering agents into the eye . They might be fairly easy to creat DIY with MCT-oil, polysorbate and propylene gylcol.

US Patent # 9,149,453. Microemulsion topical delivery platform - Patents.com

1. A method of treating a disease of the posterior segment of the eye, comprising: topically administering to an eye of a subject in need thereof a composition comprising an oil-in-water microemulsion comprising (i) an oil selected from the group consisting of isopropyl myristate, isopropyl palmitate, and medium chain triglycerides; (ii) a pair of surfactants selected from the group consisting of two polysorbates, a polysorbate and propylene glycol, a polysorbate and glycerol, a polysorbate and 1,2,3-triacetoxypropane, polyethoxylated castor oil and 1,2,3-triacetoxypropane, and polyethoxylated castor oil and propylene glycol; (iii) water; and (iv) a therapeutically effective amount, for treating a disease of the posterior segment of the eye, of a lipophilic active pharmaceutical ingredient (API), wherein: the API represents about 0.01 to about 5 percent (w/v) of the composition; the water represents 50 to about 95 percent (w/w) of the composition; the oil and the pair of surfactants represent substantially all of the remainder of the composition; the ratio of percent (w/w) the pair of surfactant to percent (w/w) the oil is at least about 10:1; and the composition is formulated for topical administration to the eye.
 
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LeeLemonoil

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There is a eyedrop product available in Germany which' main active is potassium-iodate. It is described to aid to prevent (!) cataract and treat dry eye. According to the manufacturer, iodine eye bath are a traditional method fr patients with dry eye in traditional spa-locations / therapeutic bath

Optima Pharmazeutische GmbH - LentoNit® K
 
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