Carbon Dioxide - Carbs Vs Fat Oxidation

[Mito]

Interesting things I learned about carbon dioxide from one of the videos in Masterjohn's energy metabolism series:

• Carbohydrate oxidation consumes 50% less water than fat oxidation.
  • Maybe a higher carb lower fat diet requires drinking less liquid?
• Carbohydrate oxidation generates 50% more carbon dioxide than fat oxidation.
  
  • More carbohydrates in the diet increases blood carbon dioxide levels.
• Vitamin K uses carbon dioxide to give proteins the ability to bind to calcium. So carbon dioxide is import for the following Vitamin K functions:
  • Blood clotting
  • Preventing soft tissue calcification and mineralizing bones and teeth
  • Energy utilization and hormonal health
• Biotin uses bicarbonate for many of its actions on proteins.

Does a low carbohydrate diet decrease carbon dioxide levels enough that it interferes with the critical Vitamin K and Biotin actions on proteins? Masterjohn suggests that no one has studied this.

The video goes through all the detailed biochemistry.

 

[tca300]

Awesome! Thanks!

 

[Regina]

I'd be interested in some discussion on Masterjohn's thoughts here. Haidut?
Someone with lung illness should breathe less?

 

[Mito]

Someone with lung illness should breathe less?

Here is the study he sited: High fat, low carbohydrate, enteral feeding lowers PaCO2 and reduces the period of ventilation in artificially ventilated patients. - PubMed - NCBI
Seems like he was using this as an example of a therapeutic way to decrease the burden on the lungs in an emergency situation. Something you would do only until the lungs recovered.

It would be very interesting to see a study on the effects on the Vitamin K or Biotin protein actions in someone that's been on a long term low carb/high fat diet. I suppose no one is willing to pay for a study like that?

 

[Travis]

Does a low carbohydrate diet decrease carbon dioxide levels enough that it interferes with the critical Vitamin K and Biotin actions on proteins? Masterjohn suggests that no one has studied this.

It has been studied to a small extent.

The Effect of High Fat and High Carbohydrate Diets on Rates of Weight Loss in Mice

 

[Mito]

More from Masterjohn on CO2 in this video (starts at 6 minute mark)

• CO2 is critically important to preventing the accumulation of lactic acid in the cell
• CO2 is critically important to delivering oxygen to the cell for ATP creation
• CO2 is a small gas the easily escapes the cell. CO2 leaving the cell acts as a signal that the cell is engaging in energy utilization. CO2 acts directly on hemoglobin to cause the release of oxygen so more oxygen is delivered where it is needed

 

[Mito]

I'd be interested in some discussion on Masterjohn's thoughts here. Haidut?
Someone with lung illness should breathe less?

Haidut and others discuss C02 and respiration rate in this older thread Bicarbonate Vs. PaCO2 Blood Tests