The Nitric Oxide (NO) Theory Of Aging

Luann

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And a final question, do you guys try to eat high in lysine and low in arginine? Certainly there are other amino acids that factor into that balance but is that a good guideline?
 
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haidut

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Third post in a row! Haha. Haidut you said iNOS is a concern, according to these studies it (iNOS) can be inhibited though (through arginine).

http://www.bu.edu/alzresearch/files/2014/08/arginine-Ryu.pdf

http://www.bu.edu/alzresearch/files/2014/08/arginine-Ryu.pdf

(O look: asthma and NO https://www.researchgate.net/profil..._astmatics/links/0deec537390fbb2d78000000.pdf)

Carry on

There is probably a negative feedback mechanism where arginine downregulates iNOS since it is itself a precursor to NO. so there is no need to stimulate iNOS to make even more.
 

pboy

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This is something fascinating to me and goes beyond diet. What is aging? have you not noticed that most people after a certain age start showing signs of having less heart, a more fatalistic and or depressed, pecimisstic view of the world? Their radiance and glow and zest for life goes way down. These usually correlate first with the end of high school, when people have to go 'into the real world' (the authoritative 9-5 bound in time and burden world), later towards late 20's, and by the time most are in their early 30's you can tell they are either somone with some deeper passion for life and refusal to accept this situation (rare) or someone who's very presence if somewhat befouling, no offense, not that its bad, but just their energy is somewhat of a 'tug back' to the pure optimism and enthusiasm one might bring. The thing is, in life, a lot of situations are things one must have to endure and overcome, meet the challenge, learn from it, don't lower their standards, know that righteousness wins out, perform heroic feats if necessary, or the easier alternative, lose faith in life, become somewhat stagnant and have a deep 'depression' on the basic notion that life is and can be sweet, moreso than less. How many people can endure and stay true to light despite situations that might be difficult or demanding for long periods of time, even year or more? But if one does, the rewards are special. The point really is that I definitely think nitric oxide is related to aging, and its an internal thing. Can one handle it and have faith, when things are tough, or does one let the 'depression' set in? There are many times where a passion is there and it seems 'hopelessly' choked off, which might give rise to NO within, but one can eradicate it with but the notion that things are part of a progression, for the better, and that righteousness does in fact win in the end, and that the greater forces in life are in fact benevolent and fair ultimately, and grow through the challenge rather than accept it as an inevitable situation in life. The thing about having the energy to meet the demand is huge...or by not being 'gut bound', 'bowel bound'. Quite honestly its much easier to resist NO even in situations where it might be triggered strongly as long as one's physical body is healthy and energy is flowing and GI is flowing, which diet plays a big part in. Of course the worse offenders might be allergens, to the gut and therefore flow, heart, and mind, but id say meat is pretty bad too...when parathyroid is triggered even at all its a potent estrogen promoter and seems to 'choke off' one's voice and being and expression. Grains are bad not just because their lack of nutrients, but grains, eggs, and some other things seem to quite literally direct the consciousness to the bowel retentive instead of foreward barrier breaking mentality...hence the problems with many and all civilizations and their rigid astringent bowel based attitudes. Theres a lot to this story but basically keep making progress, keep cleaning up your energy, and keep optimism and faith, and have what it takes physically mentally spiritually to meet challenenges even if it takes a deep will and commitment and refusal to become a person who sheds negative energy, and NO cant stay around long. Even in a rut, if clear progress is seen or felt, even just one step in the right direction, dopamine surges, doing noble acts increases thyroid, and these both knock out NO pretty significantly
 
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haidut

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This is something fascinating to me and goes beyond diet. What is aging? have you not noticed that most people after a certain age start showing signs of having less heart, a more fatalistic and or depressed, pecimisstic view of the world? Their radiance and glow and zest for life goes way down. These usually correlate first with the end of high school, when people have to go 'into the real world' (the authoritative 9-5 bound in time and burden world), later towards late 20's, and by the time most are in their early 30's you can tell they are either somone with some deeper passion for life and refusal to accept this situation (rare) or someone who's very presence if somewhat befouling, no offense, not that its bad, but just their energy is somewhat of a 'tug back' to the pure optimism and enthusiasm one might bring. The thing is, in life, a lot of situations are things one must have to endure and overcome, meet the challenge, learn from it, don't lower their standards, know that righteousness wins out, perform heroic feats if necessary, or the easier alternative, lose faith in life, become somewhat stagnant and have a deep 'depression' on the basic notion that life is and can be sweet, moreso than less. How many people can endure and stay true to light despite situations that might be difficult or demanding for long periods of time, even year or more? But if one does, the rewards are special. The point really is that I definitely think nitric oxide is related to aging, and its an internal thing. Can one handle it and have faith, when things are tough, or does one let the 'depression' set in? There are many times where a passion is there and it seems 'hopelessly' choked off, which might give rise to NO within, but one can eradicate it with but the notion that things are part of a progression, for the better, and that righteousness does in fact win in the end, and that the greater forces in life are in fact benevolent and fair ultimately, and grow through the challenge rather than accept it as an inevitable situation in life. The thing about having the energy to meet the demand is huge...or by not being 'gut bound', 'bowel bound'. Quite honestly its much easier to resist NO even in situations where it might be triggered strongly as long as one's physical body is healthy and energy is flowing and GI is flowing, which diet plays a big part in. Of course the worse offenders might be allergens, to the gut and therefore flow, heart, and mind, but id say meat is pretty bad too...when parathyroid is triggered even at all its a potent estrogen promoter and seems to 'choke off' one's voice and being and expression. Grains are bad not just because their lack of nutrients, but grains, eggs, and some other things seem to quite literally direct the consciousness to the bowel retentive instead of foreward barrier breaking mentality...hence the problems with many and all civilizations and their rigid astringent bowel based attitudes. Theres a lot to this story but basically keep making progress, keep cleaning up your energy, and keep optimism and faith, and have what it takes physically mentally spiritually to meet challenenges even if it takes a deep will and commitment and refusal to become a person who sheds negative energy, and NO cant stay around long. Even in a rut, if clear progress is seen or felt, even just one step in the right direction, dopamine surges, doing noble acts increases thyroid, and these both knock out NO pretty significantly

So, in a sentence - "Say NO to NO"? :):
 
L

lollipop

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This is something fascinating to me and goes beyond diet. What is aging? have you not noticed that most people after a certain age start showing signs of having less heart, a more fatalistic and or depressed, pecimisstic view of the world? Their radiance and glow and zest for life goes way down. These usually correlate first with the end of high school, when people have to go 'into the real world' (the authoritative 9-5 bound in time and burden world), later towards late 20's, and by the time most are in their early 30's you can tell they are either somone with some deeper passion for life and refusal to accept this situation (rare) or someone who's very presence if somewhat befouling, no offense, not that its bad, but just their energy is somewhat of a 'tug back' to the pure optimism and enthusiasm one might bring. The thing is, in life, a lot of situations are things one must have to endure and overcome, meet the challenge, learn from it, don't lower their standards, know that righteousness wins out, perform heroic feats if necessary, or the easier alternative, lose faith in life, become somewhat stagnant and have a deep 'depression' on the basic notion that life is and can be sweet, moreso than less. How many people can endure and stay true to light despite situations that might be difficult or demanding for long periods of time, even year or more? But if one does, the rewards are special. The point really is that I definitely think nitric oxide is related to aging, and its an internal thing. Can one handle it and have faith, when things are tough, or does one let the 'depression' set in? There are many times where a passion is there and it seems 'hopelessly' choked off, which might give rise to NO within, but one can eradicate it with but the notion that things are part of a progression, for the better, and that righteousness does in fact win in the end, and that the greater forces in life are in fact benevolent and fair ultimately, and grow through the challenge rather than accept it as an inevitable situation in life. The thing about having the energy to meet the demand is huge...or by not being 'gut bound', 'bowel bound'. Quite honestly its much easier to resist NO even in situations where it might be triggered strongly as long as one's physical body is healthy and energy is flowing and GI is flowing, which diet plays a big part in. Of course the worse offenders might be allergens, to the gut and therefore flow, heart, and mind, but id say meat is pretty bad too...when parathyroid is triggered even at all its a potent estrogen promoter and seems to 'choke off' one's voice and being and expression. Grains are bad not just because their lack of nutrients, but grains, eggs, and some other things seem to quite literally direct the consciousness to the bowel retentive instead of foreward barrier breaking mentality...hence the problems with many and all civilizations and their rigid astringent bowel based attitudes. Theres a lot to this story but basically keep making progress, keep cleaning up your energy, and keep optimism and faith, and have what it takes physically mentally spiritually to meet challenenges even if it takes a deep will and commitment and refusal to become a person who sheds negative energy, and NO cant stay around long. Even in a rut, if clear progress is seen or felt, even just one step in the right direction, dopamine surges, doing noble acts increases thyroid, and these both knock out NO pretty significantly
This. Keep energy balance high enough to maintain positivity in face of whatever exists in external situations or environments. I once heard a saint in India while I was there say that the hardest spiritual practice was to smile, a genuine smile.
 

Makrosky

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This is something fascinating to me and goes beyond diet. What is aging? have you not noticed that most people after a certain age start showing signs of having less heart, a more fatalistic and or depressed, pecimisstic view of the world? Their radiance and glow and zest for life goes way down. These usually correlate first with the end of high school, when people have to go 'into the real world' (the authoritative 9-5 bound in time and burden world), later towards late 20's, and by the time most are in their early 30's you can tell they are either somone with some deeper passion for life and refusal to accept this situation (rare) or someone who's very presence if somewhat befouling, no offense, not that its bad, but just their energy is somewhat of a 'tug back' to the pure optimism and enthusiasm one might bring. The thing is, in life, a lot of situations are things one must have to endure and overcome, meet the challenge, learn from it, don't lower their standards, know that righteousness wins out, perform heroic feats if necessary, or the easier alternative, lose faith in life, become somewhat stagnant and have a deep 'depression' on the basic notion that life is and can be sweet, moreso than less. How many people can endure and stay true to light despite situations that might be difficult or demanding for long periods of time, even year or more? But if one does, the rewards are special. The point really is that I definitely think nitric oxide is related to aging, and its an internal thing. Can one handle it and have faith, when things are tough, or does one let the 'depression' set in? There are many times where a passion is there and it seems 'hopelessly' choked off, which might give rise to NO within, but one can eradicate it with but the notion that things are part of a progression, for the better, and that righteousness does in fact win in the end, and that the greater forces in life are in fact benevolent and fair ultimately, and grow through the challenge rather than accept it as an inevitable situation in life. The thing about having the energy to meet the demand is huge...or by not being 'gut bound', 'bowel bound'. Quite honestly its much easier to resist NO even in situations where it might be triggered strongly as long as one's physical body is healthy and energy is flowing and GI is flowing, which diet plays a big part in. Of course the worse offenders might be allergens, to the gut and therefore flow, heart, and mind, but id say meat is pretty bad too...when parathyroid is triggered even at all its a potent estrogen promoter and seems to 'choke off' one's voice and being and expression. Grains are bad not just because their lack of nutrients, but grains, eggs, and some other things seem to quite literally direct the consciousness to the bowel retentive instead of foreward barrier breaking mentality...hence the problems with many and all civilizations and their rigid astringent bowel based attitudes. Theres a lot to this story but basically keep making progress, keep cleaning up your energy, and keep optimism and faith, and have what it takes physically mentally spiritually to meet challenenges even if it takes a deep will and commitment and refusal to become a person who sheds negative energy, and NO cant stay around long. Even in a rut, if clear progress is seen or felt, even just one step in the right direction, dopamine surges, doing noble acts increases thyroid, and these both knock out NO pretty significantly

What do you think about surrendering ? About giving up ? I'm not thinking about a drowning rat experiment but more in a metaphysical way. Like some saints and sages have been saying for a long time. Surrender. Life is wiser than you and have something for you that you're blocking by resisting.
Something you can't not even imagine. If you would just let happen what has to happen....

What do you think ?
 

pboy

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not ideal, I get what they mean, ultimately its a balance...its something that may take a bit to get it mastered to a good extent. Its a fine line but in a lot of ways it seems easier cause a lot of people are in tough situations, impoverished...sometimes life lessons take a lot to do or are difficult in multitude of ways, they can take meditation and mental processing, looking at, to kind of raise understanding, and a will to do genuinely. Its a fine line, basically don't force against a grain too much but also don't be overly passive and let yourself be leaky weak taken advantage of, or very importantly, lose your sense of genuinity and really voice of truth...having a 'firey' but calm metabolism, quick but graceful, things like that. Theres as far as I can tell no salvation in giving up, I think what they mean more is give up on a false ego that may think certain things...which to be honest I never had much of so that was never an issue for me...its kind of you meditate on righteousness, and pursue it in life, and see along the way how life seems to operate, but at the same time you have to 'prod' the issues, you have to do the thinking, be 'awake' and observant, enter novel situations, speak with courage and really don't know a better word to use but have the balls to confront situations that might be more 'difficult' but from a more pure mindset. Also the 'giving up' kind of thing, its sort of a way of saying to truly be objective you have to come from a pure mindset and not have tension, its much easier to see, feel, pursue truth, be observant, without tension, which for a lot of people is there due to 'others expectations' or other things put into them, so they cant be too objective or come from their own heart and voice. However, lowering tension and listening intimately is very big, but it doesn't mean do not act...in fact id say at and for many points on the learning journey...a strong will is of paramount importance and nearly if not as equally important as other factors...its more of a righteous non tense will grounded in seeking, that doesnt give up, and is willing to be steadfast in righteousness and or enter situations that will ultimately be better, pay off, but aren't necessarily things you would 'want' to jump into based on the common definition of that word...but truly theres times where you have to to grow or find higher things in life, or make huge releases. This wasn't a situation I was in but say someone wronged someone and kind of left it on the table...it might not be easy to go confront that person and apologize, but if you 'give up', ignore it, dont look at it, but you know its there, youre pacifying the guilt...you have to at least meditate on it and get straight (which to do well takes energy, and a 'desire' not in a bad way). If you with honor, truth, actually just go do it, and mean it cause you've realized tis right to consider how you might've effected others, you do it, and then the 'weight' is off...sort of translate that to life in various situations. Its not always about letting go of 'weight' or 'detoxyfying' your lfie, from upbringing ect, environemtnal influences, but also in the pursuit of higher things
 
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Regina

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What do you think about surrendering ? About giving up ? I'm not thinking about a drowning rat experiment but more in a metaphysical way. Like some saints and sages have been saying for a long time. Surrender. Life is wiser than you and have something for you that you're blocking by resisting.
Something you can't not even imagine. If you would just let happen what has to happen....

What do you think ?
Thx for the cool commentary pboy! Makrovsky, there is a "throw yourself away" to my zen/aikido training which I find very energizing. I'm not too into the word "faith." It is more like a releasing any grip on anything that isn't actually there. It is a yielding, more than a surrender. There is an active discard of what is not there. I find it in all things helpful. Even trivial things.
 

Makrosky

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Thx for the cool commentary pboy! Makrovsky, there is a "throw yourself away" to my zen/aikido training which I find very energizing. I'm not too into the word "faith." It is more like a releasing any grip on anything that isn't actually there. It is a yielding, more than a surrender. There is an active discard of what is not there. I find it in all things helpful. Even trivial things.
I like to play with those ideas and post them from time to time just as a reminder that there are 5000 years of wisdom before Peat was born ;-)
 

pboy

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i guess to paraphrase above, 'surrender' to your heart and voice and go on your journey discovery and experience, don't let outside voices, doubt, tensions, 'must do's exactly', though sometimes you might kind of for whatever reason, its more like that. And surprisingly enough, I think this is a natural thing...something people are born knowing to follow, but of course various factors impair that or impede and people more or less get obstructed in that regard until a commitment to returns, preferably fully!
 

PeatThemAll

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What do you think about surrendering ? About giving up ? I'm not thinking about a drowning rat experiment but more in a metaphysical way. Like some saints and sages have been saying for a long time. Surrender. Life is wiser than you and have something for you that you're blocking by resisting.
Something you can't not even imagine. If you would just let happen what has to happen....

What do you think ?

Reminds me of Blaise Pascal: "Renunciation, total and sweet."
 

Makrosky

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i guess to paraphrase above, 'surrender' to your heart and voice and go on your journey discovery and experience, don't let outside voices, doubt, tensions, 'must do's exactly', though sometimes you might kind of for whatever reason, its more like that. And surprisingly enough, I think this is a natural thing...something people are born knowing to follow, but of course various factors impair that or impede and people more or less get obstructed in that regard until a commitment to returns, preferably fully!
yeah pboy, I get your point. I was talking though on a more complete level of surrendering. I am gonna talk just as it comes out of my mind. Kind of brainstorming. I see people claim (myself included) “Oh yeah, since I follow Peat ideas I’ve been feeling best than in years... BUT... if I don’t take a doubleespresso-coffee with 5 supps, coconut oil, sit under a red light lamp and a tablespoon of gelatin, then I feel like ***t and crash very badly for the next days”. What kind of health is that ? This is...basically you are a slave of your rituals. Yeah, I take whatever steroids and androgens and I am muscular, tall, my face gets round, my gyno pectoral diminishes... and to what kind of selfimage are you hooked to ? The one in movies and cosmopolitan magazines? Look at the general populations of countries with higher expectancy of life, they don’t look like that. You micromanage everything in your life, till the point of inserting in your computer every single food you take to count the calories. Where is freedom in that ? Where is the place in your life for the UNEXPECTED to come in and surprise you ? You have an arsenal of supps and foods at your hands and one should wonder... am I using them to reinforce and support my constructed fake self-image (totally cultural imposed by the way)? I have a very close friend, who suffers important health issues (insomnia, IBS kind of stuff, etc.) but he plays the piano wonderfully, and creates songs that are marvelous. Now take this guy and tell him he has to dedicate a very big ammount of his free time to become his own MD. Trying supps, tweaking diet, reading papers and boards. Where does the music go ? To the trash. You micromanage everything. When you are sad and you just want to sit at the piano and compose a song that reflects that... hah! two drops of antiserotonindrug to the rescue. I feel fine again, goodbye to the piano song. (until something else unbalances of course).

What’s the difference about being hooked to artificial insulin or being hooked to a myriad of personal rituals like the peaty foods and supps and bright light 30 mins a day and no more and exercise yes but not aerobic and fruit yes but only ripe and so on... ? There are many differences, good and bad, one of them is that the first one will take that and keep up with life, the second one there’s a big risk it gets hooked to becoming his/her own MD for the rest of his life.

Oh yea, I am very bad on picking up girls, let’s take some androgens and see how it goes. Where are your inner resources, man ? We have totally forgotten them. We are projecting our inner strenghts, our will, into outside things. It reminds me a lot of the Wizard of Oz movie. Worth re-watching it. What does Dorothy do ? She jumps into life, into the journey. Moves on. Her travel mates are Nitric Oxide, TSH and DHEA levels. Oh my god, I can’t do nothing, my TSH is very high, I don’t empathize with others. Oh my god, how am I gonna survive, my DHEA levels are not on the top limit, I can’t make love to anyone. Look, poor me, my nitric oxide is through the roof, I can’t accomplish anything. What happens ? They discover they had the power and internal resources to do what they had to do. They kill the witch and they complete the journey. And Dorothy knows that she were always able to return to her inner place of peace and wellbeing just by somethig as simple as clapping her shoes. What did they do ? Did they stopped to take blood tests and supps ? NO. They just moved on. Trusting. Surrendering to the journey.

In contrast, if you surrender, you accept things. You accept your body as it is. You accept there are things in life you are not in control of. There’s something very liberating in going to the doctor, take the prescribed pill or surgery, and go on with your life. Don’t take this as an authoritarian or low-energy adapting to establishment thing. Don’t take this as an excuse for trying to improve and discover more healthy methods. Just try to stick to the “liberation” feeling you (or someone you know that does that) gets when you can liberate yourself from being your own doctor (and saviour) and go on with your life.

You sit under fluorescent lamps al day in a dull office, doing mechanical work, with colleagues as bored as you, you go home and you have very bad sex with your wife, and whatnot. Your NO goes up, you start to feel fatigued (and depressed) and what do you do ? You run to buy strange foods and supps to give you more energy to keep doing the same thing and to artificially up libido. Are you fullfilling your sexual fantasies ? Do you find any meaning in the work you do ? What if you surrender ? It all will fall like one of those castles made with cards (I don’t know the word in english). And what happens there ? Then there’s maybe a chance for something more authentic to you to come. In greek mythology caos is always needed to give birth to something new.

How many theories about health, the world, everything do you hold ? Aren’t all them a maniac resisting like thing to protect you from the unknown? from the unexpected ? When you are in a boat that is sinking, you have to throw over to the sea a lot of unnecessary baggage. Then something really new (not new under your own prism, like REALLY new) can get into your life.

I hope you don’t get lost in the details and get the true “spirit of the message” I’m saying. All I am saying is heavy caricaturized and biased on purpose, please don’t take me wrong. I do all those micromanagement things all the time. I read papers and articles all the time and really can’t imagine myself not doing that. I just want to elicit some questions in the minds of whoever might be reading this. Take it as an antiserotonin (mental routine breaking) kind of thing. I don’t know, maybe I haven’t eaten enough coconut oil today and my kerbs cycle is not working properly. Do whatever it’s fine for you. But never forget to take your dose of pboysterone in the morning.
 

DaveFoster

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Nitric oxide and aspirin: a new mediator for an old drug. - PubMed - NCBI

Aspirin is known to cause a multitude of pharmacologic actions through inhibition of cyclooxygenase(s) and reduced formation of prostaglandins. Recently, however, novel cytoprotective and antioxidant mechanisms of aspirin have been identified that are independent of cyclooxygenase inhibition. It was shown that aspirin directly stimulates the activity of endothelial nitric oxide (NO) synthase without affecting the expression of endothelial NO synthase. Increased NO formation was found to underlie aspirin-induced sustained protection of endothelial cells from oxidant injury. Downstream targets of NO that mediate tissue protection include the stress proteins heme oxygenase-1 (HO-1) and ferritin. Both HO-1 and ferritin have been identified as targets of, and inducible by, aspirin and, in the case of HO-1, aspirin-triggered lipoxins. It is important to note that these effects are specific to aspirin and not induced by other nonsteroidal antiinflammatory drugs such as diclofenac, indomethacin, or salicylates or by selective cyclooxygenase-2 inhibitors. HO-1 and its antioxidant product bilirubin have been reported to be not only involved in vasoprotection, but to have a similar function in gastric tissue. Stimulation of NO formation through aspirin and ensuing HO-1 induction might therefore help to reduce gastric injury or irritation. Moreover, NO functions as a smooth muscle-relaxing agent and is thus thought to counteract the reduction in gastric blood flow caused by inhibitors of prostaglandin synthesis. It is therefore conceivable that activation of these novel antioxidant pathways contributes, at least in part, to gastric tolerability and the favorable cardiovascular safety profile of aspirin.

It seems that aspirin can lead to increased levels of NO in some cases. This seems odd though, as the nitric oxide theory of aging contributes the aging to NO, and Dr. Peat has offered aspirin as a novel anti-aging compound.

Effects of aspirin-like drugs on nitric oxide synthesis in rat vascular smooth muscle cells. - PubMed - NCBI

The purpose of this study was to investigate the effects of aspirin-like drugs on nitric oxide (NO) synthesis in rat vascular smooth muscle cells (VSMCs). We measured the accumulation of nitrite, a stable oxidation product of NO, and the expression of inducible NO synthase (iNOS) mRNA and protein in rat cultured VSMCs. Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Increased nitrite production by aspirin-like drugs was accompanied by increased iNOS mRNA and protein accumulation in VSMCs. Addition of IL-1beta activated nuclear factor kappaB (NF-kappaB) in VSMCs, but sodium salicylate did not affect IL-1beta-induced NF-kappaB activation. The nonselective lipoxygenase (LO) inhibitor nordihydroguaiaretic acid inhibited sodium salicylate-induced nitrite production, whereas the selective 5-LO inhibitor caffeic acid did not influence production of nitrite. The 12-LO product 12-HETE dose-dependently enhanced nitrite production by IL-1beta-stimulated VSMCs, whereas the 15-LO product 15-HETE did not. Our study demonstrates that aspirin and the aspirin-like drugs, sodium salicylate and indomethacin, increase NO synthesis in IL-1beta-stimulated VSMCs by upregulation of iNOS transcription via a 12-LO pathway. These effects were independent of NF-kappaB activation. In addition to the direct inhibition of platelet function, aspirin-like drugs may contribute to the reduction of atherothrombotic risk in myocardial ischemia via enhancing NO production by VSMCs.

Although aspirin increases NO activity in rat vascular smooth muscle cells, it lowers NO expression in the brain:

Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats. - PubMed - NCBI

The precise mechanisms by which stress induces brain damage are still being elucidated. The high-output, inducible isoform of nitric oxide (NO) synthase (iNOS) is expressed in rat brain after immobilisation stress and its inhibition protects against cell damage in this condition. We have hereby explored some mechanisms involved in iNOS expression and studied the effects of aspirin, a NSAID with neuroprotective actions, in this model. Acute (6 h) stress exposure in rats caused brain expression of iNOS, an increase in plasma glutamate and brain TNF-alpha, induction of oxidative indicators in brain and a fall in brain ATP levels. Prior administration of aspirin (10 mg/kg i.p.) inhibited all these effects caused by stress, suggesting possible therapeutic implications of this drug in this condition.
 
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Agent207

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Aging is when at the 30s or 40s you don't appear like in the 20s anymore, when you lack the speed and explosiveness from then, and the stress tolerance. Melanocyte homogeneity begins to decline, elastin and fibroblasts get damaged, loss of collagen leads to sagging skin, dropped eyelids... all this related and paired with increased mitochondrial disfunction, hormonal imbalance and toxin accumulation. Not to talk about the innocence...

There's a lot of perspectives of aging, but that's what almost everyone cares the most.
 
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DaveFoster

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Can we get some clarification on eNOS versus iNOS. iNOS is obviously awful, inflammatory, leads to cancer, but what's the deal with eNOS? Aspirin increases eNOS, so can we please get some clarification on this point.
 
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haidut

haidut

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Can we get some clarification on eNOS versus iNOS. iNOS is obviously awful, inflammatory, leads to cancer, but what's the deal with eNOS? Aspirin increases eNOS, so can we please get some clarification on this point.

The iNOS appears to be simply a barometer of inflammation while eNOS is not. So, stress, PUFA and everything along those lines will increase iNOS but not affect eNOS. Not sure high eNOS is that good either but there are studies that show low eNOS is not good.
Nitric oxide synthase - Wikipedia
Endothelial NOS - Wikipedia
 

DaveFoster

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The iNOS appears to be simply a barometer of inflammation while eNOS is not. So, stress, PUFA and everything along those lines will increase iNOS but not affect eNOS. Not sure high eNOS is that good either but there are studies that show low eNOS is not good.
Nitric oxide synthase - Wikipedia
Endothelial NOS - Wikipedia
That's what I was thinking. The latter seems much more prevalent, and less accentuated in disease states. Thanks for the info.
 

Regina

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This is something fascinating to me and goes beyond diet. What is aging? have you not noticed that most people after a certain age start showing signs of having less heart, a more fatalistic and or depressed, pecimisstic view of the world? Their radiance and glow and zest for life goes way down. These usually correlate first with the end of high school, when people have to go 'into the real world' (the authoritative 9-5 bound in time and burden world), later towards late 20's, and by the time most are in their early 30's you can tell they are either somone with some deeper passion for life and refusal to accept this situation (rare) or someone who's very presence if somewhat befouling, no offense, not that its bad, but just their energy is somewhat of a 'tug back' to the pure optimism and enthusiasm one might bring. The thing is, in life, a lot of situations are things one must have to endure and overcome, meet the challenge, learn from it, don't lower their standards, know that righteousness wins out, perform heroic feats if necessary, or the easier alternative, lose faith in life, become somewhat stagnant and have a deep 'depression' on the basic notion that life is and can be sweet, moreso than less. How many people can endure and stay true to light despite situations that might be difficult or demanding for long periods of time, even year or more? But if one does, the rewards are special. The point really is that I definitely think nitric oxide is related to aging, and its an internal thing. Can one handle it and have faith, when things are tough, or does one let the 'depression' set in? There are many times where a passion is there and it seems 'hopelessly' choked off, which might give rise to NO within, but one can eradicate it with but the notion that things are part of a progression, for the better, and that righteousness does in fact win in the end, and that the greater forces in life are in fact benevolent and fair ultimately, and grow through the challenge rather than accept it as an inevitable situation in life. The thing about having the energy to meet the demand is huge...or by not being 'gut bound', 'bowel bound'. Quite honestly its much easier to resist NO even in situations where it might be triggered strongly as long as one's physical body is healthy and energy is flowing and GI is flowing, which diet plays a big part in. Of course the worse offenders might be allergens, to the gut and therefore flow, heart, and mind, but id say meat is pretty bad too...when parathyroid is triggered even at all its a potent estrogen promoter and seems to 'choke off' one's voice and being and expression. Grains are bad not just because their lack of nutrients, but grains, eggs, and some other things seem to quite literally direct the consciousness to the bowel retentive instead of foreward barrier breaking mentality...hence the problems with many and all civilizations and their rigid astringent bowel based attitudes. Theres a lot to this story but basically keep making progress, keep cleaning up your energy, and keep optimism and faith, and have what it takes physically mentally spiritually to meet challenenges even if it takes a deep will and commitment and refusal to become a person who sheds negative energy, and NO cant stay around long. Even in a rut, if clear progress is seen or felt, even just one step in the right direction, dopamine surges, doing noble acts increases thyroid, and these both knock out NO pretty significantly
Word!! That was great pboy.
 

jyb

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What kind of health is that ? This is...basically you are a slave of your rituals.

If you're in that situation then I think the problem is more that you're actually still not in good health just applying some bandaid to cope with symptoms - good health necessarily implies some robustness, so you could handle a change for a while without noticing much. Like when you were a kid. Like eating junk food or skipping meals on a busy day, if you're in good health then going through that is no problem to repair - you wouldn't go sick for the afternoon. A rigid metabolism is a common indicator of poor health, look up articles on "metabolic flexbility".
 
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