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The Lower Your Cortisol Levels, The Younger You Look

Discussion in 'Scientific Studies' started by haidut, Apr 24, 2017.

  1. haidut

    haidut Member

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    Peat has this quote popping up on the forum every once in a while.
    “The main features of aging can be produced... | Ray Peat Forum
    "..."...The main features of aging can be produced directly by administering excessive amounts of cortisol. These features include atrophy of skin, arteries, muscle, bone, immune system, and parts of the brain, loss of pigment (melanin), deposition of fat in certain areas, and slowed conduction velocity of nerves. The physiology of aging (especially reproductive aging) overlaps the physiology of stress.”

    Forum user @LeeLemonoil recently posted this study, explaining the effects of glucocorticoids on the aging epigenome.
    Cortisol Sets "aging-clock" Ahead

    And now this study found that the perceived age of a person is strongly affected by their cortisol levels. So, anti-glucocorticoid substances could be a legitimate aspect of anti-aging therapies. Given the powerful anti-cortisol effects of pregnenolone, it would explain why Peat looked visibly younger after his mega-dose pregnenolone experiment he wrote about.
    http://www.psyneuen-journal.com/article/S0306-4530(12)00068-6/abstract
    "...This study demonstrates that high levels of cortisol are associated with a higher perceived age. This association was attenuated in offspring from long-lived families compared to their partners, suggesting enhanced stress resistance in these subjects. Future research will be aimed at elucidating potential mechanisms underlying the observations in this study."
     
  2. TubZy

    TubZy Member

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    I think a lot of the pro skin properties from pregenolone mainly are coming from the conversion into progesterone. I seemed to notice the benefit when both supplementing them separately.
     
  3. OP
    haidut

    haidut Member

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    Yep, quite possibly one of the beneficial pathways. There is an old study floating around the forum somewhere with topical steroids for skin anti-aging. Testosterone has the biggest effects, but progesterone was also up there.
     
  4. encerent

    encerent Member

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    You can lower your stress, sleep more and reverse your prematurely aged looks.
     
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