Reversal Of Benign Prostate Hyperplasia By Selective Occlusion Of Impaired Venous Drainage In Males

TreasureVibe

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Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment

First International Journal of Andrology Andrologia

Y. Gat1,2, M. Gornish1 , M. Heiblum2 & S. Joshua3
1 Andrology and Interventional Radiology Unit, Maayanei HaYeshua Medical Centre, Bnei Brak, Israel;
2 Braun Center for Sub Micron Research, Department of Condensed Matter Physics, Weizmann Institute of Science, Rehovot, Israel;
3 Department of Chemistry, Technion, Israel Institute of Technology, Haifa, Israel

Accepted July 30, 2008

Summary - The prostate is an androgen-regulated exocrine gland producing over 30% of the noncellular components of the semen and promoting optimal conditions for survival and motility of sperm in the vagina. Benign prostate hyperplasia (BPH) is the most common benign neoplasm in men. Its aetiology is not clear, and therefore, current medical treatments are directed towards the symptoms. Though testosterone is known to be the promoter of prostate cell proliferation, no causal relation between serum testosterone levels and BPH has been found. In this study, we propose a novel and tested pathophysiological mechanism for the evolution of BPH and suggest a tested and effective treatment. We found that in all BPH patients, the one-way valves in the vertically oriented internal spermatic veins are destroyed (clinically manifested as varicocele), causing elevated hydrostatic pressure, some 6-fold greater than normal, in the venous drainage of the male reproductive system. The elevated pressure propagates to all interconnected vessels leading to a unique biological phenomenon: venous blood flows retrograde from the higher pressure in the testicular venous drainage system to the low pressure in the prostatic drainage system directly to the prostate (law of communicating vessels). We have found that free testosterone levels in this blood are markedly elevated, with a concentration of some 130- fold above serum level. Consequently, the prostate is exposed to: (i) increased venous pressure that causes hypertrophy; (ii) elevated concentration of free testosterone causing hyperplasia. We have treated 28 BPH patients using a technique that restores normal pressure in the venous drainage in the male reproductive system. The back-pressure and the back-flow of blood from the testicular to the prostate drainage system were eliminated and, consequently, a rapid reduction in prostate volume and a regression of prostate symptoms took place.

Source: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1439-0272.2008.00883.x
 
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rei

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Any more details on this? To me it almost seems too good to be true. A cause and cure for prostate overgrowth presented a decade ago, yet this is the only place i have seen it referenced.
 
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TreasureVibe

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Good article, thank you for sharing
Glad to help.

Any more details on this? To me it almost seems too good to be true. A cause and cure for prostate overgrowth presented a decade ago, yet this is the only place i have seen it referenced.
Varicocele is the root cause of BPH: Destruction of the valves in the spermatic veins produces elevated pressure which diverts undiluted testostero... - PubMed - NCBI
Varicocele is the root cause of BPH: Destruction of the valves in the spermatic veins produces elevated pressure which diverts undiluted testosterone directly from the testes to the prostate.
Scientific publications
גת גורן, טיפולי פריון לגבר, טסטוסטרון או ערמונית מוגדלת
Varicocele: the origin of benign prostatic hypertrophy? Testosterone dosages in the periprostatic plexus. - PubMed - NCBI
https://onlinelibrary.wiley.com/doi/pdf/10.1111/iju.12583
The Prevalence and Association of Varicoceles on Male Patients With Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms. - PubMed - NCBI
Factor Impacting Prostate and Urinary Problems in Older Men Possibly Identified - BPH News
Treatment of benign prostatic hyperplasia by occlusion of the impaired urogenital venous system - first experience. - PubMed - NCBI (same procedure as in opening post study, but by different physicians, year 2015)
Clinical correlates of enlarged prostate size in subjects with sexual dysfunction. - PubMed - NCBI


"According to the results of study, it was found that in patients with varicocele, attention should pay to the status of the venous outflow from the pelvic organs, which leads to the pelvic congestion and causes degenerative changes in the prostate in half of cases, which in turn negatively affects the spermogram parameters and increases the risk of subfertility."

From: [Potentials for the conservative therapy in the complex treatment of varicocele in adolescents]. - PubMed - NCBI

Prostate cancer: a newly discovered route for testosterone to reach the prostate : Treatment by super-selective intraprostatic androgen deprivation. - PubMed - NCBI
Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. - PubMed - NCBI

There's more, but this is what a quick internet browsing got me. The link with the Hebrew letters leads to the clinic's website run by Dr. Gat and Dr. Goren who did these discoveries and developed the subsequent treatment, and is in english.
 
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SOMO

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I read the study and there's nothing in there that is useful for the average person with mild or even progressive BPH.

The "therapy" the study recommends costs several THOUSAND dollars $$$.
Unless one is skilled enough to operate on their own scrotum, how is this applicable.

I for one noticed changes in my prostate from Saw Palmetto, which is very inexpensive.

This study is good news for those with varicocele/BPH, but only if you're willing to accept surgical intervention.
 
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TreasureVibe

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I read the study and there's nothing in there that is useful for the average person with mild or even progressive BPH.

The "therapy" the study recommends costs several THOUSAND dollars $$$.
Unless one is skilled enough to operate on their own scrotum, how is this applicable.

I for one noticed changes in my prostate from Saw Palmetto, which is very inexpensive.

This study is good news for those with varicocele/BPH, but only if you're willing to accept surgical intervention.
I think that the significance of the actual proven healing of BPH through fixing the venous drainage system shouldn't be underestimated. Now that I think of it, I have never heard of any non-visible veins that are attached to the prostate. But apparently they exist, and if they show problems, then prostate enlargement is the result. It could even be that these veins have problems, without the visible pampiniform plexus being varicosed i.e. being a varicocele.

So even without a varicocele you could still have problems with the non-visible veins that drain the prostate, causing benign prostate hyperplasia.

I found the actual veins: Prostatic venous plexus - Wikipedia

Saw palmetto is bad news I've read before, it could mess up things forever.

Saw Palmetto harms the prostate and does not block DHT
Saw Palmetto Killed My Friend

I've also read multiple anecdotal reports of people saying saw palmetto made them impotent. So I don't know, I personally wouldn't touch it.

Saw palmetto is a 5 alpha reductase inhibitor, just like the drug Finasteride which is infamous for causing impotence and Post Finasteride Syndrome (PFS), which currently is still not curable.

It can also cause liver damage, source: Saw Palmetto & Estrogen

And erectile dysfunction, source: Side Effects of Saw Palmetto on Men


Hormones cause varicose veins. Varicose veins cause back flow, bypassing of the blood, stagnant blood, leakiness of the veins etcetera. Where are hormones most frequently present? The pelvic area. So it wouldn't be such a strange idea that varicose veins cause BPH. Varicose veins that can't be seen, too.

Also very relevant and possibly implied in BPH, endotoxin. See this:
Prostate Enlargement (BPH) May Be Due To Endotoxin

And take a good look at this picture:

afp20020501p1834-f1.jpg


Source: Neurologic Complications of Prostate Cancer

If either the vesical venous plexus or the prostatic venous plexus or both are varicosed, have valve problems, or any venous problem, it could mean less drainage from the prostate, it could mean retrograde flow of hormone-rich blood into the prostate.

Also see this:
Thousands of men to benefit from new prostate therapy | Daily Mail Online (2017)
New prostate therapy recommended on NHS (2018)
Pioneering prostate treatment for tens of thousands of men gets NHS green light (2018)

A 1,000 patients prostate enlargement/BPH treatment trial has been finished with succes and just greenlighted by the British NHS, and it comprises of.. Prostatic Artery Embolization. Yet the blood vessels of the prostate aren't relevant according to you?

See: Surgical Treatment: Prostate Artery Embolization


Both venous and arterial ways of occlusion/embolization aren't seen as real surgery anyway, see:
Nonsurgical treatment for enlarged prostate remains effective for years

In fact, venous embolization in varicocele (the regular varicocele embolization treatment) also shows results for BPH:
[Interventional treatment of benign prostatic hyperplasia : Embolization of the testicular vein]. - PubMed - NCBI
 
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rei

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By destroying veins it sounds like you end up creating hypoxic area ripe for conversion into cancer. Huge SUCCESS turning BPH into cancer.

So why did they opt for destroying veins instead of fixing the one-way valves?
 
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TreasureVibe

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By destroying veins it sounds like you end up creating hypoxic area ripe for conversion into cancer. Huge SUCCESS turning BPH into cancer.

So why did they opt for destroying veins instead of fixing the one-way valves?
It's the arteries, not the veins that they embolize. I'm unsure if the artery actually gets destroyed, or if blood flow just gets impaired through the presence of the plastic beads. It's a novel technique, and it claims to have long term success. Indeed, if it were up to me, I'd go the venous route, and get the dysfunctional prostatic venous plexus fixed, as was showcased in the study of the opening post.

But it seems that this prostatic artery embolization is going to be the new big thing for prostate problems. Long term safety of the procedure was also guaranteed so far, I think they started trials back in 2012. It could be longer ago. It's now 6 years later and according to them it's safe. Ofcourse 6 years is not a guarantee for a life time safety record. If the British National Health Service (NHS) who is responsible for all the medical staff and hospitals in the UK, appears to implement it, it sure says something. The main developer predicts it will become the new standard for BPH treatment, replacing surgery in the next couple of years. The novel technique was developed in Portugal.

Why the national and international urologists/radiologists boards etc. opted for the arterial route instead of the venous route is something I don't know. Perhaps it's ignorance. Although I did read that the venous method was being studied in Belgium and was already being performed in the UK. I'm unsure on what scale.
 
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rei

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Reason is most probably that it is very easy (and therefore cheap) to do. They don't care about how bad it is, just that it does not produce fatal outcomes.

Just like removal of prostate, it is very safe if you survive the operation. But no thought is given in these statistics of secondary negative outcomes that are often devastating. Like impotence.
 
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TreasureVibe

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Reason is most probably that it is very easy (and therefore cheap) to do. They don't care about how bad it is, just that it does not produce fatal outcomes.

Just like removal of prostate, it is very safe if you survive the operation. But no thought is given in these statistics of secondary negative outcomes that are often devastating. Like impotence.
I think that is why it is so important that the origin of prostate cancer and BPH is studied more, namely on a forum like this one for example. Why does BPH happen?

Also see this: Is there a link between BPH and prostate cancer? - PubMed - NCBI
 

rei

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"BPH is not a known risk factor for prostate cancer, although the two frequently coexist."

Translated: It starts to overgrow, and in unhealthy/susceptible patients that results in cancer.

Probably because unhealthy means that the body cannot support the growth demanded by the orders of magnitude increased testosterone from back-flow.
 
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TreasureVibe

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"BPH is not a known risk factor for prostate cancer, although the two frequently coexist."

Translated: It starts to overgrow, and in unhealthy/susceptible patients that results in cancer.

Probably because unhealthy means that the body cannot support the growth demanded by the orders of magnitude increased testosterone from back-flow.
The selective venous occlusion did not resolve BPH for some patients reported anecdotally on the internet, I'm uncertain about the success rate in the opening post study, I can't figure it yet from reading it. It could be that those procedures where it didn't show significant results were done by specialists that are still unexperienced with the technique, as it is rather new. Or, as I theorized, didn't encompass other venous plexuses that were varicosed, which could also contribute to BPH, theoretically. Or the prostate is physiologically not able to shrink enough even with a fully functioning venous drainage system. A case of ''too far gone'' or so to say. Or it would take years for it to shrink and undo the enlargement, with the venous drainage system functioning again, perhaps.

Also see this: Prostate Enlargement (BPH) May Be Due To Endotoxin


"...simultaneous treatment of intact...rats with testosterone and estradiol-17beta for 16 weeks consistenly induced a putative precancerous lesion, termed dysplasia, in the dorsolateral prostate of all animals. Since treatment of rats with androgen alone did not elicit the same response, we concluded that estrogen played a critical role in the genesis of this proliferative lesion." Shuk-mei Ho and M. Yu, in "Selective increase in type II estrogen-binding sites in the dysplastic dorsolateral prostates of Noble rats," Cancer Research 53, 528-532, 1993.

Source: Ray Peat article on Prostate Cancer: Prostate Cancer
 
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OVERVIEW
Over 80% of patients with prostate cancer respond to androgen deprivation using drugs or surgery that marked reduce male sex hormone (testosterone) and related androgen levels from the body. Anti-androgens are a class of drugs that specifically block the entry of testosterone into cells of the body, thus preventing its biological effects. Examples of such drugs that are available on the U.S. market include flutamide (Eulexin®), bicalutamide (Casodex®) and nilutamide (Nilandron™). Cyproterone (Androcur) is another anti-androgen that is not available in the U.S.

In approximately 50% of patients whose cancer has started to grow again despite treatment that includes an antiandrogen, the cancer has been noted to regress by simply stopping the anti-androgen. This unusual response is referred to as the Anti-Androgen Withdrawal Response (AAWR). Scientists theorize that prostate cancer cells exposed to antiandrogens for a prolonged time may mutate(undergo genetic change) that paradoxically causes the anti-androgen to stimulate cancer growth.

Although more research is needed, we believe a trial of stopping the anti-androgen for a period of time is warranted in order to determine whether or not an AAWR may occur before considering other types of treatment. A review of the scientific studies that support this treatment approach follows below:

The anti-androgen withdrawal response (AAWR) may be seen, in up to 50% of patients who have PSA relapse while receiving androgen blockade. An AAWR response usually lasts 6 to 8 months, but for some patients, may last as long as 2 years.

Source: " AAWR" THE ANTI-ANDROGEN WITHDRAWAL RESPONSE

The doctor was asked why the avodart prescription, and why "too much testosterone" is the problem when younger men have more. His answer, for the record, was that the swollen prostate provides more testosterone receptors due to its larger size, hence effectively more testosterone reaching and acting on the prostate. He is a leading urologist (spell predictor keeps wanting to say ufologist and maybe that's more accurate) so there's the official line for you. o_O

Source: Summary Of Prostate Improvements
 
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TreasureVibe

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Maybe any hormone or blend of hormones can cause cancer in the prostate, when given enough through failing veins that cause backflow. Or more compounds, perhaps secreted from the prostate itself, flow back into it and accumulate there due to failing veins.

Perhaps these prostate secretions, in combination with aforementioned blend of hormones could even cause cancer.

Function[edit]
Male sexual response[edit]
Main article: Prostate massage
During male seminal emission, sperm is transmitted from the vas deferens into the male urethra via the ejaculatory ducts, which lie within the prostate gland. Ejaculation is the expulsion of semen from the urethra. It is possible for some men to achieve orgasm solely through stimulation of the prostate gland, such as prostate massage or anal intercourse.[18][19][20]

Secretions[edit]
Prostatic secretions vary among species. They are generally composed of simple sugars and are often slightly alkaline.[21] In human prostatic secretions, the protein content is less than 1% and includes proteolytic enzymes, prostatic acid phosphatase, beta-microseminoprotein, and prostate-specific antigen. The secretions also contain zinc with a concentration 500–1,000 times the concentration in blood.

Regulation[edit]
To function properly, the prostate needs male hormones (androgens), which are responsible for male sex characteristics. The main male hormone is testosterone, which is produced mainly by the testicles. It is dihydrotestosterone (DHT), a metabolite of testosterone, that predominantly regulates the prostate.

Source: Prostate - Wikipedia
 
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TreasureVibe

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Basically what the Gat Goren technique is, is embolization of varicosed prostate veins. He injects a synthetic gel like substance into the varicosed veins that he can see on his screen. Dr. Gat says, like all other urologists do when it comes to vascular problems in the organs of the pelvis, that the varicosed prostate veins are a result of dysfunctional/broken valves. While this may be the case in some, especially those who are older (above the age of 50), in alot of cases the valves could still be functional and not broken, but the veins are varicosed anyways, due to estrogen, or due to prostate size by itself which lowers output power.

If the gel dissolves and therefore healing the varicosed veins, or if the gel stays like it is is something you have to figure. If the gel dissolves over time, it goes against the dogma that valves are broken (and cannot repair) that urologists maintain.
 
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Lokzo

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Glad to help.


Varicocele is the root cause of BPH: Destruction of the valves in the spermatic veins produces elevated pressure which diverts undiluted testostero... - PubMed - NCBI
Varicocele is the root cause of BPH: Destruction of the valves in the spermatic veins produces elevated pressure which diverts undiluted testosterone directly from the testes to the prostate.
Scientific publications
גת גורן, טיפולי פריון לגבר, טסטוסטרון או ערמונית מוגדלת
Varicocele: the origin of benign prostatic hypertrophy? Testosterone dosages in the periprostatic plexus. - PubMed - NCBI
https://onlinelibrary.wiley.com/doi/pdf/10.1111/iju.12583
The Prevalence and Association of Varicoceles on Male Patients With Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms. - PubMed - NCBI
Factor Impacting Prostate and Urinary Problems in Older Men Possibly Identified - BPH News
Treatment of benign prostatic hyperplasia by occlusion of the impaired urogenital venous system - first experience. - PubMed - NCBI (same procedure as in opening post study, but by different physicians, year 2015)
Clinical correlates of enlarged prostate size in subjects with sexual dysfunction. - PubMed - NCBI


"According to the results of study, it was found that in patients with varicocele, attention should pay to the status of the venous outflow from the pelvic organs, which leads to the pelvic congestion and causes degenerative changes in the prostate in half of cases, which in turn negatively affects the spermogram parameters and increases the risk of subfertility."

From: [Potentials for the conservative therapy in the complex treatment of varicocele in adolescents]. - PubMed - NCBI

Prostate cancer: a newly discovered route for testosterone to reach the prostate : Treatment by super-selective intraprostatic androgen deprivation. - PubMed - NCBI
Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. - PubMed - NCBI

There's more, but this is what a quick internet browsing got me. The link with the Hebrew letters leads to the clinic's website run by Dr. Gat and Dr. Goren who did these discoveries and developed the subsequent treatment, and is in english.

Sensational findings.
 

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