What would be a physiological dose of progesterone to take from noon to evening for support the circadian cortisol rhythm? Thanks
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What would be a physiological dose of progesterone to take from noon to evening for support the circadian cortisol rhythm? Thanks
Ultimately, I didn't have much luck with the DHEA. Eventually, it makes me agitated.Hi Owen, I'd be curious to know how this combo has worked out for you. I'm hyper-sensitive to most supplements, especially hormones, and I'm always looking for success stories that I might be able to mimic.
Yeah, that is what DHEA does to me as well.Ultimately, I didn't have much luck with the DHEA. Eventually, it makes me agitated.
But looking back on it now the 10 mgs of progesterone was too much by itself. It should be taken with something androgenic to balance it.
I'd up my Estroban too to get some D3 in my system. It works well with androgenic hormones and progesterone. See the main D3 (Calcirol) thread.
Low dose progesterone makes it difficult for me to get an erection.
High dose progesterone makes it even more difficult.
I have no issues getting erections immediately before or a few hours after using progesterone.
N=1 though, but I think RP has made it pretty clear that Progesterone is more of a "female" hormone.
It's unfortunate that Progesterone has this effect in me because it has other benefits, specifically neurological benefits and a significant positive mood lift.
I think the issue is lowering cortisol too much which is needed for morning wakefulness. After a few hours of wakefulness, cortisol can be abated without causing drowsiness if used in physiological doses. Drowsiness can still occur in higher doses but if done afternoon it feels more like drunkenness and less like sleepiness.
Yeah, as with phyto-oestrogens it has some EReceptor binding and also Estrogen displacing properties.Hi General, I've seen you mention licorice here before but I'd been led to believe that it was estrogenic?
Do those benefits apply to 6 keto progrsterone as well? Also, why do some people get anxiety from pregnenolone?
https://www.sciencedirect.com/science/article/pii/S0048969716326420
Progesterone potentially degrades to potent androgens in surface waters
Don‘t know if this has been posted anywhere. According to that paper, Progrsterone in water (excreted into sewerage I assume / in surface water) can turn into potent androgens among other things.
Xeno-Androgens? Yeay! Ban Progesterone for good that can only mean.
Seems an interesting paper worth reading, some good descriptions on steroid-breakdown and transformations in the environment.
Would 50mg daily injections create an anti- androgenic effect? I need to upregulate my AR's. Can 50mg do that via competing with AR's so they start to upregulate to compensate?I would say 10mg-15mg daily is physiological dose. But it has to be split into several lower doses. A single dose of 10mg-15mg is not physiological.
I would say 10mg-15mg daily is physiological dose. But it has to be split into several lower doses. A single dose of 10mg-15mg is not physiological.