I've just started using MB. I put one drop on the inside of my right wrist. The drop just stayed there. I then used my little finger on my other hand to rub in the drop. The rubbed in drop covered a one inch square on my wrist in blue. The little finger on my other hand also turned blue. I put the drop on at 3pm. The next day in the morning my wrist was still blue. The blue on my little finger was gone. Since I workout with weights in the morning, I had to wash off the blue on my wrist cuz I workout with a tee shirt and a blue wrist would look weird. It took a lot of scrubbing with soap and water to remove the blue dye from my wrist. It did not come off easily. Today I tried 2 drops on the top of my foot. I'll see how long it takes to disappear. I think it would be easier to try oral with one drop a glass of water. However, I don't know whether oral, since it has to go through the liver is as effective as skin application.