Omega 3 Reduces Myogenesis And Promotes Adipogenesis

[Hans]

Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation
"This study suggests that the maternal overdosage of EPA and DHA may influence fetal muscle development, increase intramuscular adipose tissue deposition in offspring, and have a long-term effect on the development of metabolic diseases such as obesity and diabetes in adult offspring."

Fish oil supplementation suppresses resistance exercise and feeding‐induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men
"Supplementation (with fish oil) significantly decreased panPKB activity at REST in the FO group but not the CO (coconut oil) group. There was a significant increase from REST at post‐RE (resistance exercise) for PKB and AMPK α2 activity in the CO group but not in the FO group. In FEDEX, there was a significant increase in p70S6K1 activity from REST at 3 h in the CO group only. These data highlight that 8 weeks of FO supplementation alters kinase signaling activity in response to RE plus protein ingestion without influencing MPS."

 

[ecstatichamster]

Very good studies. I wish I understood the second one better. Thank you

 

[Hans]

PI3K -> Akt (a.k.a. PKB) -> mTOR -> p70S6K1 (S6 kinase). So fish oil lowers PKB and S6K1