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TreasureVibe
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Fish oil is recommended by people on the basis of its DHA content, a large lipid with six double‐bonds found in the brain. This is absolutely essential as is demonstrated by those having Zellweger's syndrome. However, we don't need to consume DHA to have it in our brains; most animals and over 99% of people can simply make it themselves from the precursor α-linolenic acid, which is found in leaves and grass‐fed cheese.
Beta‐carotene is also found in leaves and vitamin A in cheese, should that be the argument for fish oil.
I personally don't think its worth taking. It is smelly, oxidized, and the high vitamin A + PUFA content of CLO can give a person liver damage. If someone is depressed, I think things like lotus stamens and vitamin D would be better—and safer. A person could perhaps even grow poppies.. .
as far as I know ray argues that omega 3 and such are not essential because the body can produce mead acid... but what if in some persons for whatever reason the mechanism of mead acid production is hindered? on those people might benefit from low amounts of omega3 for example? i mean it would be better to why the mead acid production isn't working and how to fix that... ... genes can be activated/deactivated Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency. - PubMed - NCBI
so might be when the autoimmune disease is triggered or on those genes for mead acid aren't on.
Fish oil is recommended by people on the basis of its DHA content, a large lipid with six double‐bonds found in the brain. This is absolutely essential as is demonstrated by those having Zellweger's syndrome.
Can you please elaborate on why or how people with Zellweger's prove that DHA is essential?
Because they have profound cholesterol ingression in the brain—visualized via MRI as 'white matter' in the 'grey matter'—and have IQ's under 70. While you may be able to actually survive for some having cell membranes composed of only ω−9 fatty acids, this represents such a pathology that ω−3 fatty acids should be considered essential. Only small amounts are needed for DHA synthesis however, amounts so small as to be unavoidable. The real danger is consuming so much ω−6 fatty acids that DHA elongation enzymes are inhibited, raising the requirement and causing a mild form of Zellweger's. Arachidonic acid (20∶4ω−6) is not as effective as DHA in excluding sterols from the cell membrane, and the enhanced potency of its eicosanoid derivatives represent a pathology of an entirely different nature. I think the best science indicates that trace amounts of ω−3 fatty acids are needed, but also that we can rest assured that ω−6 fatty acids are still 100% unnecessary and entirely inimical.
Ok, but I don't see how Zellwegers disease proves that DHA is essential, because to my knowledge nobody has demonstrated that DHA deficiency causes Zellweger's...
There are review articles on Zellweger's disease.
Most rat experiments and human trials I have seen show DHA to be ineffective.
Most? I suppose you hadn't actually bothered to read the study you'd linked.
'In previous open studies [7,8], it had been stated that DHA supplementation was associated with improvements in vision and growth of these children.' ―Parker
[7.] Martinez M. "Docosahexaenoic acid: a new therapeutic approach to peroxisomal-disorder patients—experience with two cases." Neurology (1993)
[8.] Martinez M. "Restoring the DHA levels in the brains of Zellweger patients." J Mol Neurosci (2001)
Now which rat experiments exactly had you been referring to?
Yes there is, here are some quotes from the study you'd posted:That's no evidence that DHA does anything for Zellwegers.
After I ruined my health with Veganism, fish oil brought my mental state back to normal. After several years of being on the vegan diet, I started getting depressed and it wasn't anything to do with my environment or home life. Also Fish oil cured my back acne.
There are definite neurological effects of Fish Oil, likely due to the DHA.
Regardless of how you feel about PUFA, there are people who find benefit from Omega 6 supplements like Borage/Evening Primrose Oil or Omega 3s like Fish Oil/Cod Liver Oil.
But aren't you the same guy who'd said he'd been hospitalized for sodium deficiency?
Interestingly, two common pathways, neuroprotection and anti-inflammation, have been found to be associated with all the antidepressant drugs.21,24) More importantly, these two common mechanisms link to antidepressant effects not only for drugs but also for non-pharmacological treatment omega-3 PUFAs.6,11,20) Indeed, the effects on neuroprotection and anti-inflammation support the promising hypothesis of psychoneuroimmunology of mood and anxiety disorders and provide an excellent interface between “mind” and “body”.
The deficits in omega-3 PUFA levels have been reported in other populations with mood disorders, including lower DHA and total n-3 PUFAs in postpartum depression 31) and lower DHA and EPA in social anxiety disorder.32) In the elderly patients, lower DHA and higher AA, n-6/n-3, AA/EPA, and AA/DHA ratios were associated with depressive disorders compared to healthy volunteers.33) In samples of patients with acute coronary syndromes, the depressed patients had lower DHA, total DHA and EPA; and higher AA, n-6/n-3, AA/EPA and AA/DHA than those without depression.34) Interestingly, lower DHA levels before starting interferon (IFN)-α therapy predicted IFN-α-induced depression in patients with chronic hepatitis C viral (HCV) infection.13)