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After about a week of taking 200mg, I felt like I was getting uncoupling effects and lost some weight. My waking temps were around 99 but pulse did not change. It also made me able to focus and do much longer stretches of mental effort. Mood improved a lot as well. Similar to the effects of a very high dose methylene blue (60mg). However, with that dose of methylene blue I experienced very pronounced increase in serotonin and it is not something that can be maintained for more than a few days. With MitoLipin (both topical and oral) I felt much more blissful, without the nervousness from the serotonin of high dose methylene blue. I guess the effects I got from MitoLipin are not that surprising since it acts very similar to methylene blue but through a different pathway. Methylene blue is an electron carrier and alternative oxidizing agent. MitoLipin acts like an antagonist of PUFA, so re-saturates the mitochondrial lipids. So, its effects are a bit like depleting yourself of PUFA but you don't have to wait 4 years to accomplish that
I hope that answers your questions.
Sweet. Did you apply it topically or take it orally?Amazing product. Took my first dose today and immediately noticed benefits.
At first I got really calm and had a sensation of pure bliss, I just sat on my bed nodding like a druggie.
Then I noticed twitching muscles in my back and over the course of about 15 minutes my whole back relaxed bit by bit and all the pain and discomfort I had there for months/years vanished. It is unbelievable to me.
My mood is incredibly good now and I feel wide awake, but at the same time I am incredibly relaxed and not jittery.
Didn't expect such a drastic effect, atleast not that quickly.
Thank you @haidut !
So i spilled about 1/4 of a bottle on my rats arm by accident. Other than being very thirsty today the only side effect ive noticed is a great mood (very social, talkative etc.)
@haidut anything i should be worried about?
Amazing product. Took my first dose today and immediately noticed benefits.
At first I got really calm and had a sensation of pure bliss, I just sat on my bed nodding like a druggie.
Then I noticed twitching muscles in my back and over the course of about 15 minutes my whole back relaxed bit by bit and all the pain and discomfort I had there for months/years vanished. It is unbelievable to me.
My mood is incredibly good now and I feel wide awake, but at the same time I am incredibly relaxed and not jittery.
Didn't expect such a drastic effect, atleast not that quickly.
Thank you @haidut !
Sweet. Did you apply it topically or take it orally?
No mixing with water, the PC is so hydrophobic that it will immedietaly precipitate and form a whitish cloud inside the liquid. For the people that choose on their own volition to take orally, taken on its own is best. It has enough fat and vitamin E in it to ensure absorption.
8 drops and The Mammal literally "trips". ... Can it be stored in a fridge as my room teperatures may hit +25C in summer?
Is there chance that phosphatidilcholine can dissolve lipofuscin?
haidut said:Topical Administration:
- The skin-permeation-enhancing effect of phosphatidylcholine: caffeine as a model active ingredient.
- The hypocholesterolemic and antiatherogenic effects of topically applied phosphatidylcholine in rabbits with heritable hypercholesterolemia.
- Effects of phosphatidylcholine on the topical bioavailability of corticosteroids assessed by the human skin blanching assay.
General/Miscellaneous:
- Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.
- Biochemical effects of phosphatidylcholine treatment in rats.
- Rapid stopping of A23187 action by phosphatidylcholine.
- Blockade of alpha-adrenergic receptors by analogues of phosphatidylcholine.
- The effect of mixed phosphatidylcholine liposomes on beef heart cytochrome c oxidase [proceedings].
- Cytochrome c Interaction with Cardiolipin/Phosphatidylcholine Model Membranes: Effect of Cardiolipin Protonation
- Inhibition of mammalian cytotoxic cells by phosphatidylcholine and its analogue
- Studies on cytochrome oxidase. Interactions of the cytochrome oxidase protein with phospholipids and cytochrome c.
Inflammation:
- Anti-inflammatory action of a phosphatidylcholine, phosphatidylethanolamine and N-acylphosphatidylethanolamine-enriched diet in carrageenan-induced...
- Anti-inflammatory effects of phosphatidylcholine.
- Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury.
- Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.
Brain/Memory/Mood/Cognition/Nervous system:
- Protective effects of phosphatidylcholine on oxaliplatin-induced neuropathy in rats.
- Dietary phosphatidylcholine improves maze-learning performance in adult mice.
- Impairment of brain mitochondrial functions by β-hemolytic Group B Streptococcus. Effect of cardiolipin and phosphatidylcholine.
- Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat.
- Effect of phosphatidylcholine on explicit memory.
- A report on phosphatidylcholine therapy in a Down syndrome child.
- A REPORT ON PHOSPHATIDYLCHOLINE THERAPY IN A DOWN SYNDROME CHILD
- EARLY RESULTS FROM DOUBLE BLIND, PLACEBO CONTROLLED TRIAL OF HIGH DOSE PHOSPHATIDYLCHOLINE IN ALZHEIMER'S DISEASE
- Combination of phosphatidylcholine and pentoxifylline in the therapy of progressive obstructive stroke.
Liver/Gallbladder:
- Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
- Accumulation of lipid in rat liver was induced by vitamin B6 deficiency and was ameliorated by supplemental phosphatidylcholine in the diet.
- Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice.
- Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholin...
- Effects of phosphatidylcholine pretreatment during acute experimental biliary reflux.
- Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid.
- Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis.
- The effect of phosphatidylcholine on repair processes in liver cells in acute CCl4 damage.
- Protective effect of phosphatidylcholine on restoration of ethanol-injured hepatocytes related with caveolin-1.
- Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.
- Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet.
- Prevention of alcohol-induced hepatic fibrosis by phosphatidylcholine.
- Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon.
Gut/Bowel/GI/Endotoxin:
- Exogenous phosphatidylcholine supplementation improves intestinal barrier defense against Clostridium difficile toxin.
- In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cells.
- Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation.
- Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial.
- First multicenter study of modified release phosphatidylcholine "LT-02" in ulcerative colitis: a randomized, placebo-controlled trial in mesalazine...
- Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion-induced methane generation and the inflammatory response in the small intestine.
- Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux.
- Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis.
- Microbial species involved in production of 1,2-sn-diacylglycerol and effects of phosphatidylcholine on human fecal microbiota.
- Protective effect of oral phosphatidylcholine on radiation-induced release of intestinal peptidases in rats.
- Phosphatidylcholine induces an increase in the production of interleukin-6 and improves survival of rats with neonatal sepsis caused by Klebsiella...
- Mucosal protection by phosphatidylcholine.
- Dietary phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis.
- Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine.
- Delayed release phosphatidylcholine as new therapeutic drug for ulcerative colitis--a review of three clinical trials.
- Low-dose aspirin-induced ulceration is attenuated by aspirin-phosphatidylcholine: a randomized clinical trial.
- Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis?
- Phosphatidylcholine as a constituent in the colonic mucosal barrier--physiological and clinical relevance.
- Association of phosphatidylcholine and NSAIDs as a novel strategy to reduce gastrointestinal toxicity.
- Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study.
- TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells.
- Phosphatidylcholine reverses ethanol-induced increase in transepithelial endotoxin permeability and abolishes transepithelial leukocyte activation.
- Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats.
- Phosphatidylcholine and intraperitoneal adhesions.
- Effect of phosphatidylcholine on postoperative adhesions after small bowel anastomosis in the rat.
- Effects of phosphatidylcholine and phosphatidylinositol on acetic-acid-induced colitis in the rat.
Heart/Kidney:
- Protective role of phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats.
- Intraperitoneal administration of phosphatidylcholine improves ultrafiltration in continuous ambulatory peritoneal dialysis patients.
Cancer:
- Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
- Mitogenic effects of phosphatidylcholine nanoparticles on MCF-7 breast cancer cells.
- Phosphatidylcholine induces growth inhibition of hepatic cancer by apoptosis via death ligands.
Obesity/Diabetes/Metabolism:
- Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice.
- Effect of oxidized phosphatidylcholine on biomarkers of oxidative stress in rats.
- Phosphatidylcholine induces apoptosis of 3T3-L1 adipocytes.
- A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.
Bones:
- Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats.
- Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis.
Anti-viral/anti-bacterial:
- Immunization of mice with phosphatidylcholine drastically reduces the parasitaemia of subsequent Plasmodium chabaudi chabaudi blood-stage infections.
- Reduction of HIV-1 antigen production by phosphatidylcholine containing formulations via growth inhibition of HIV-1-infected cells.
- Growth inhibition of HIV-1-infected cells and membrane alterations induced by phosphatidylcholine.
- Effect of phosphatidylcholine cholesterol liposomes on the growth of bacterial cultures.
I have suffered from pale stools and liver congestion for years. I had thrush and low serum cholesterol. After a few days of 40 drops/day MitoLipin and then continuing with 10 drops/day (topical), my stools are now a normal dark brown. The thrush is gone. My stools are less sticky and require less wiping, as well.
I've underestimated this product for a long time.
How long overall was it before you noticed results? still taking it?