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Ketotifen?
- Thread starter rw39
- Start date
Ketotifen has some good properties and the one I like the most is that it is an endotoxin (TLR4) antagonist:
TLR4 - Wikipedia
The issue with it is that it seems to raise NO in some studies but if you feel well on it and the doctor thinks it is OK then it is probably at least as good as cypro in terms of anti-allergy effects. I don't think it has anti-serotonin effects though.
No, I had not seen it so thanks for sharing. It does seem like ketotifen may inhibit serotonin liberation from platelets, which would make it a functional serotonin antagonist, for a lack of better term. But the concentrations used were really high - 1mM / L, which would require ingesting grams of ketotifen per dose to reach that level. Obviously not something you want to do. I don't know if ketotifen has the same effect in the lower doses used clinically.
Yeah, it seems given that and the effect on NO ,that cypro would be a better choice. There are some other studies with ketotifen and anxiety, which is why I went digging for a link to serotonin.
I took it for a couple of months more than a year or so ago. The dose was the same as in the IBS study you can search for.
It made me really cranky the first day. After that I didn't notice much. No side effects at all beyond that.
Cypro has been better.
If you're in Australia it's available from compounding pharmacies.
It made me really cranky the first day. After that I didn't notice much. No side effects at all beyond that.
Cypro has been better.
If you're in Australia it's available from compounding pharmacies.
Mossy
Member
- Joined
- Jun 2, 2017
- Messages
- 2,043
Thanks for sharing, thomas00.
Yeah, I did see the thread about it helping poor digestion, which is my objective in taking it.
When you say Cypro has been better, is that for the IBS/poor digestion, or just overall sense of well-being? Which reminds me, I did read in the other threads that ketotifen should help with PTSD.
I purchased it for someone else and he hasn’t taken any of it yet. Sorry I don’t have any feedback.
It's been more effective for IBS and mood. Ketotifen didn't seem to do much for either.
Mossy
Member
- Joined
- Jun 2, 2017
- Messages
- 2,043
Ok, that helps, as I attempt to narrow down what to try. Thanks.
energyandstruct
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- Nov 27, 2017
- Messages
- 960
tlr4 antagonists that are non toxic relatively are the main tho f I’m looking for right now. Me/cfs is chronic “low level” sepsis. Unfortunately LDN increases acth and even though it’s tlr4 antagonist it also is somewhat steroid like and increases blood pressure a lot sometimes.
Do you really think that the NO increase from ketotifen would present problems ? I’ve heard nothing but good things about it so far. One person with mast cell issues that lead to hospitalization for anaphylaxis said high dose ketotifen was the only thing that kept him stable.
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