I've Never Seen Hairloss/pattern Baldness Like Mine. Lost 70% Of My Hair In 4-5 Years

Hairfedup

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Hey guys...gonna just jump right into this. I've been losing or should I say, just lost, most of my hair since around age 20-21. I'm 25 now. It really probably started at 18. I've studied everything - Ayurveda, Chinese traditional, heat in the body theory, onion, fenugreek oil. Everything. I always knew that something had to be wrong inside my body; always had a feeling that hairloss is inherently linked to the inside, the body conveying what's really going on through mechanisms such as baldness. Onion did work for me back in 2014...I gained a lot of hair back. Now it seems useless. At 25, I guess I've got 30-40% hair left, maybe less. That's what lead me to Peat/Roddy and I've been studying and studying. A post here by the name of Elephanto made a lot of sense to me and I've been researching and looking in to everything he layed out in an earlier post for the past few months. Before I give a back ground, like I mentioned in the title of this post, my hair loss isn't like what I've seen on hundreds if not thousands of heads online and in real life. I haven't gone up a Norwood scale. Its just like bang...diffuse hair loss across the entire frontal part of the skull and then vertex balding across the crown. I wouldn't even mind if I had balded like most men, receeding over years and years. I don't know how to upload a picture just yet but I will when I figure it out lol.

After reading up a lot of peat/roddy and of course the experience of users on here, I'm absolutely certain that I'm estrogen dominant and probably hypothyroid. I've been tested for thyroid but my Doctor was unfortunately way past it and offered no advice. Just that she didn't think I had thyroid. I've suffered with stretchmarks all over my stomach since a late teen (seriously, a large meal at one point would give me a rip pink 1-2inch stretch mark, my largest is 5 inches). My hair loss is crazy. Although I was a national level sprinter till about 18, my muscles are incredibly weak...if I do 5 chin ups and wait 10 minutes I won't be able to pull myself up on the bar..pure exhaustion of the forearms...its very hard to explain. I regularly wake up with sore triceps after doing nothing at all. Doctors say its just stress lol. I do believe that stress, cortisol and hairloss are intrinsically linked; men that 'feel' and are unable to shut down feeling inevitably suffer...your sociopathic successful men rarely lose hair. Anyway before I go off on a tangent, my prostate gives me issues at this young age...I basically have to be on Nofap for my prostate not to feel heavy, tight, painful or have strange little spasms. I've been addicted to porn since age 12 and fapped regularly 4 x a day. I know the naysayers will never believe it but I'm sure its played a major role. Prolactin must be super high. Although I can go 7-8 hours without eating easily, my thyroid/throat literally aches if I've not eaten, even if I'm not hungry. I'm sure my metabolism has completely crashed from the yoyo dieting as a teen and young athlete. I have severe anterior-pelvic tilt and vaulted stomach but I can't be certain thats part of my issues - maybe its genetic but I have a hunch. Oh yeah in regards to prostate, the biggest issues I've had with it have been on my most successful year of Nofap (2017) which I find surprising...I guess its how people get sick AFTER they stop smoking etc. I did smoke a pack a day but only for a year when I studied in Egypt. Been cold turkey since 2013.

That's pretty much all I can think of right now - you guys really need to see a picture I think. My hair texture went from thick curly wavy to tight soft curls to bald. I don't know if ethnicity has to do with it ..... Before the heavy hair loss, I always assumed I had the 'ethnic' hair line but now I realise it was most likely minor receding at the temples. A part of me does think that some sort of incompatible gene expression occurred and has left me with his strange, very sick looking baldness. That's the only way I can describe it. Very sick looking - ill and diseased.

Please let me know what you think, like I said I'll be trying [most of but not all] of user Elephanto's protocol...I'm really desperate at this point, not so much even for the hair growing back but for insight into the sickly nature of it and into hormonal/thyroid/prostate issues which I now know are all intimately linked.

p.s. I have a Vitamin D defficiency, the only thing I know for certain. Taking 1 20,000 IU pill once a week prescribed by doctor, no soya etc. Been eating a carrot a day for the last two weeks and coconut oil, a few tablespoons. The craziest thing is my diet is super healthy my whole life: we eat fusion food, never overspiced but a lot of cumin, turmeric, coriander, onions. I eat raw onions with meals as long as I remember. A lot of yoghurt. Carbs have always been cassava, plantain, corn based carbs (fufu anyone). Always fresh food, don't ever remember eating anything, honestly, processed or ready made. Really think the problem is just with me. My siblings have great health, my brother is in his 40s with a good head of hair especially with a stressful job. I suffer from depression...quite badly but never to the point I'd kill myself. V loving family, talk about everything, all my stresses and pain is talked about and worked through. I just don't know what I'm doing wrong!

pss. just remembered that I definitely think I had prostatis or something similar last summer...cleared up after 2-3 months or so. Never had any problems urinating etc so I don't know for sure how badly it effected me, but it was definitely there...heaviness, tightness, anxiety inducing and very occasionally uncomfortable to the point of pain. Oh and I never have an itchy scalp...ever...even when I had a full head of hair. Please let me know what you guys think. I'm lost.


.
 
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Just wanted to say that the exact same thing happened to me. Between 20-25 too. No noticeable onset with receding hairline or thinning crown. Just bang straight into diffuse hair loss all across the top.

I had my cortisol and prolactin tested and they were found to be extremely high.

I went low carb between 18-20, drank heavily, and had a nightmare relationship.

Shortly after, goodbye hair.
 
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Hairfedup

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Just wanted to say that the exact same thing happened to me. Between 20-25 too. No noticeable onset with receding hairline or thinning crown. Just bang straight into diffuse hair loss all across the top.

I had my cortisol and prolactin tested and they were found to be extremely high.

I went low carb between 18-20, drank heavily, and had a nightmare relationship.

Shortly after, goodbye hair.

Damn really sorry to hear that, man. Forreal. Maybe we can save our hair?
 

kayumochi

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"Taking 1 20,000 IU pill once a week prescribed by doctor"

Many physicians prescribe D2 rather than D3. Check your bottle. And 20,000 once a week isn't very much ...
 
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Hairfedup

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"Taking 1 20,000 IU pill once a week prescribed by doctor"

Many physicians prescribe D2 rather than D3. Check your bottle. And 20,000 once a week isn't very much ...

Hey its a locally made product called HuxD3 and is pure D3 Calciferol(?) with a gelatine based casing, nothing else. What kind of dose would you recommend? I'm dark skinned/brown so I need more right? Also I'm in the UK zero vitamin d anywhere. Thanks!
 
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Hairfedup

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Please guys any advice/tips and information would really be appreciated...I'm really struggling out here!
 

eddiem991

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I have always thought severe stress to be more detrimental to health than the worst diet possible.

Depression, not eating enough, chronic stress (constant sympathatic nervous activation) and running (also stresses the body) can all contribute to hairloss.
 

eddiem991

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Please guys any advice/tips and information would really be appreciated...I'm really struggling out here!

You need to put your body in rest and repair mode, eat/supplement right and your hair will slowly be coming back. Try to not think about it.
 

Travis

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Vitamin D is one of the few hormones actually required for hair growth, as it transcribes keratin 31. Hair cannot grow without this, as keratin proteins are basically hair itself.

Mice genetically bred to lack the vitamin D receptor of their skin are hairless, and this effect is not reversed by normalizing calcium.

Besides making sure we all get enough vitamin D, avoiding linoleic acid is also a good idea. Prostaglandin D₂ is the one molecule most associated with hair loss and it cannot be synthesized without linoleic acid.

Cortisol transcribes for the enzyme which converts prostaglandin H to prostaglandin D₂.

Immunogenic reactions increase cytokines which cause hair loss by creating prostaglandin D₂ in downstream cells, which is why you see hair loss patches in animals having tropical infections—interferon-γ and intereleukins-1 & -6 are doing this by transcribing for cyclooxygenase-2 and phospholipase A₂. These same hair-inhibiting cytokines can be induced by immunogenic food reactions. Generally, the most immunogenic foods are the ones having proteins with the highest proline index; wheat, dairy, oats, chocolate, and especially wheat will release cytokines from the T-cells of many people.

And there are other reasons to avoid linoleic acid (i.e. cancer) and any immunoreactive proteins you're responding to (i.e. histamine).

Vitamin D is a great vitamin, but it's also a powerful hormone and should perhaps be used with a little caution.
 
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Hairfedup

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Vitamin D is one of the few hormones actually required for hair growth, as it transcribes keratin 31. Hair cannot grow without this, as keratin proteins are basically hair itself.

Mice genetically bred to lack the vitamin D receptor of their skin are hairless, and this effect is not reversed by normalizing calcium.

Besides making sure we all get enough vitamin D, avoiding linoleic acid is also a good idea. Prostaglandin D₂ is the one molecule most associated with hair loss and it cannot be synthesized without linoleic acid.

Cortisol transcribes for the enzyme which converts prostaglandin H to prostaglandin D₂.

Immunogenic reactions increase cytokines which cause hair loss by creating prostaglandin D₂ in downstream cells, which is why you see hair loss patches in animals having tropical infections—interferon-γ and intereleukins-1 & -6 are doing this by transcribing for cyclooxygenase-2 and phospholipase A₂. These same hair-inhibiting cytokines can be induced by immunogenic food reactions. Generally, the most immunogenic foods are the ones having proteins with the highest proline index; wheat, dairy, oats, chocolate, and especially wheat will release cytokines from the T-cells of many people.

And there are other reasons to avoid linoleic acid (i.e. cancer) and any immunoreactive proteins you're responding to (i.e. histamine).

Vitamin D is a great vitamin, but it's also a powerful hormone and should perhaps be used with a little caution.

Hey! Thanks for the detailed response. I've been phasing wheat out completely, I still eat toast with marmalade (peat said its a wonder drug) every morning. You mentioned tropical infections and hair loss - I had Dengue Fever in the Summer of 2016 and my hair took a huge loss after that..never recovered. In essence I should phase out all food stuffs with a high proline index? And continue D3 dosage?

I've seen your posts in other threads, should I hop on to the A, E, K2 like everyone else? I really don't want to give up on my hair, even as terrible as its state is now. I'm certain my prostate issues and assumed low test/high estrogen+prolactin are at the heart of everything: I saw a product being linked here, called ESME-Prostate and Testogen...would these be worth looking in to? I'm so lost I don't know where to start with such severe hair loss already. Go full peat, go by user Elephanto's protocol, its so overwhelming. I know diet is so important but I find it amusing: we've been eating cherimoyas/custard apples my whole life and I still suffer from all this. I can't handle stress of modern living at all. Thanks in advance.
 
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Hairfedup

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You need to put your body in rest and repair mode, eat/supplement right and your hair will slowly be coming back. Try to not think about it.

Thanks I agree but I definitely suffer from learned helplessness and inability to mitigate stress. Sucks lol. I just feel too much. I really think that feeling is at the heart of MPB. That and a person's mother. Without offending anyone, a psychological study involving a bunch of bald/balding men and their mothers incorporating Freudian and Jungian themes (you know, before Psychology as a field was brow beaten into pushing false agendas and the protection of women) would be super interesting. Pretty sure we'll find each and every mother to be suffering from BPD+NPD.
 

Travis

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Hey! Thanks for the detailed response. I've been phasing wheat out completely, I still eat toast with marmalade (peat said its a wonder drug) every morning. You mentioned tropical infections and hair loss - I had Dengue Fever in the Summer of 2016 and my hair took a huge loss after that..never recovered. In essence I should phase out all food stuffs with a high proline index? And continue D3 dosage?

I've seen your posts in other threads, should I hop on to the A, E, K2 like everyone else? I really don't want to give up on my hair, even as terrible as its state is now. I'm certain my prostate issues and assumed low test/high estrogen+prolactin are at the heart of everything: I saw a product being linked here, called ESME-Prostate and Testogen...would these be worth looking in to? I'm so lost I don't know where to start with such severe hair loss already. Go full peat, go by user Elephanto's protocol, its so overwhelming. I know diet is so important but I find it amusing: we've been eating cherimoyas/custard apples my whole life and I still suffer from all this. I can't handle stress of modern living at all. Thanks in advance.
On a hunch I searched for interferon-γ and Denge fever. It does appear as though Denge fever is always accompanied by interferon-γ circulating at ~25–35·pg/ml average concentrations.

Chakravarti, Anita. "Circulating levels of TNFα & INFγ in patients with dengue & dengue haemorrhagic fever during an outbreak." Indian Journal of Medical Research (2006)
Braga, Elzinandes. "Detection of circulant tumor necrosis factor-alpha, soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever." Memorias do Instituto Oswaldo Cruz (2001)

This is important, and hair loss is very often accompanied by increased interferon-γ levels. What this cytokine does most powerfully is induce phospholipase A₂, which releases the lipid hormone precursor arachidonic acid from cell membrane phospholipids. This necessarily leads to higher prostaglandin H levels, which is the precursor for prostaglandin E₂ and prostaglandin D₂. The precursor prostaglandin H can only become one or the other, and which one it becomes depends largely on prostaglandin D₂ synthase levels—an enzyme under the control of cortisol. This is why there are so many factors in hair loss, as it takes the combined effort of dietary linoleic acid, phospholipase A₂, cyclooxygenase-2, and cortisol to create prostaglandin D₂.

Genetically-engineered rats with interferon-γ DNA spliced next to skin keratin 5 gene are practically hairless.

Cytokines form the molecular bridge between T cells and all other cells; they are the mediators between humoral immunity and cell-mediated immunity. Cytokines upregulate many enzymes which act against invading pathogens; here are the ones that I've read about:

Phospholipase A₂ (PLA₂): This cleaves precursor arachidonic acid from membrane phospholipids from the sn-2 position of the gylcerol backbone. This enzyme even works in vitro on the surface of artificial lipid droplets. Trust me, this enzyme is really cool and actually does as advertised.

Cyclooxygenase-2 (COX-2): This adds O₂ to arachidonic acid forming the endoperoxide ring characteristic of the prostaglandins. This is their defining trait, and this active group would be dangerous to a microbe. Plants make similar lipid peroxides when attacked, and I see it as adding reactive oxygen groups to lipids as defense (i.e. lipoxins). Prostaglandins were probably originally cell-mediated defense molecules—their hormonal functions coming later on the evolutionary timescale.

Inducible nitric oxide synthase (iNOS): This enzyme creates more nitric oxide from arginine, ostensibly as a defense measure. Of all the enyzmes listed, this is the one I know the least about.

Tryptophan dioxygenase (TDO): This is not really involved in hair loss, but is interesting nonetheless. This enzyme breaks‐open the indole ring of tryptophan, making it unavailable to microbes. The induction of this enzyme limits growth of said microbes, but it also lowers tryptophan⟶and hence brain serotonin. This enzyme is what is probably responsible for both the depression seen during infection and the loss of new muscle synthesis. Interferon-γ can lower circulating tryptophan by 50% while leaving all other amino acids unaffected.

So we have an elaborate defense scheme consisting of the T cells which first recognize a foreign antigen, the cytokines which transmit instructions to all other cells, and the enzymes induced in other cells which create defensive small molecules that work physically against the microbes. The T cells recognize an invader by the proteins it creates. This is good, but some food proteins can do the exact same thing as if by accident. The immune systems of many people also produce interferon-γ from gluten fragments, ostensibly having confused it with an invading pathogen. The immune system reacts to a good many peptides from foods, but only the ones with enzyme-resistant proline fragments have much of a chance of entering the body—such as those from gluten and casein. Seen in this way, the only thing toxic about gluten is its inability to be digested.* Sourdough bacteria have been shown to cleave these proline bonds, as has the supplemention with prolyl endopeptidase capsules; both of these have been shown to make gluten safe to eat and non-immunogenic.

Interferon-γs from Leishmania, Denge fever, or tropical sprue are indistinguishable from the interferon-γ seen after gluten ingestion (in some people.)

And lowering dietary linoleic lowers prostaglandins everywhere!

*But wheat flour does have reduced iron particles added which are probably best avoided.
 
Last edited:

kayumochi

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Joined
Oct 7, 2015
Messages
376
Hey its a locally made product called HuxD3 and is pure D3 Calciferol(?) with a gelatine based casing, nothing else. What kind of dose would you recommend? I'm dark skinned/brown so I need more right? Also I'm in the UK zero vitamin d anywhere. Thanks!

I took 10,000 iu of D3 a day for quite some with zero side effects ...
 
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Hairfedup

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On a hunch I searched for interferon-γ and Denge fever. It does appear as though Denge fever is always accompanied by interferon-γ circulating at ~25–35·pg/ml average concentrations.

Chakravarti, Anita. "Circulating levels of TNFα & INFγ in patients with dengue & dengue haemorrhagic fever during an outbreak." Indian Journal of Medical Research (2006)
Braga, Elzinandes. "Detection of circulant tumor necrosis factor-alpha, soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever." Memorias do Instituto Oswaldo Cruz (2001)

This is important, and hair loss is very often accompanied by increased interferon-γ levels. What this cytokine does most powerfully is induce phospholipase A₂, which releases the lipid hormone precursor arachidonic acid from cell membrane phospholipids. This necessarily leads to higher prostaglandin H levels, which is the precursor for prostaglandin E₂ and prostaglandin D₂. The precursor prostaglandin H can only become one or the other, and which one it becomes depends largely on prostaglandin D₂ synthase levels—an enzyme under the control of cortisol. This is why there are so many factors in hair loss, as it takes the combined effort of dietary linoleic acid, phospholipase A₂, cyclooxygenase-2, and cortisol to create prostaglandin D₂.

Genetically-engineered rats with interferon-γ DNA spliced next to skin keratin 5 gene are practically hairless.

Cytokines form the molecular bridge between T cells and all other cells; they are the mediators between humoral immunity and cell-mediated immunity. Cytokines upregulate many enzymes which act against invading pathogens; here are the ones that I've read about:

Phospholipase A₂ (PLA₂): This cleaves precursor arachidonic acid from membrane phospholipids from the sn-2 position of the gylcerol backbone. This enzyme even works in vitro on the surface of artificial lipid droplets. Trust me, this enzyme is really cool and actually does as advertised.

Cyclooxygenase-2 (COX-2): This adds O₂ to arachidonic acid forming the endoperoxide ring characteristic of the prostaglandins. This is their defining trait, and this active group would be dangerous to a microbe. Plants make similar lipid peroxides when attacked, and I see it as adding reactive oxygen groups to lipids as defense (i.e. lipoxins). Prostaglandins were probably originally cell-mediated defense molecules—their hormonal functions coming later on the evolutionary timescale.

Inducible nitric oxide synthase (iNOS): This enzyme creates more nitric oxide from arginine, ostensibly as a defense measure. Of all the enyzmes listed, this is the one I know the least about.

Tryptophan dioxygenase (TDO): This is not really involved in hair loss, but is interesting nonetheless. This enzyme breaks‐open the indole ring of tryptophan, making it unavailable to microbes. The induction of this enzyme limits growth of said microbes, but it also lowers tryptophan⟶and hence brain serotonin. This enzyme is what is probably responsible for both the depression seen during infection and the loss of new muscle synthesis. Interferon-γ can lower circulating tryptophan by 50% while leaving all other amino acids unaffected.

So we have an elaborate defense scheme consisting of the T cells which first recognize a foreign antigen, the cytokines which transmit instructions to all other cells, and the enzymes induced in other cells which create defensive small molecules that work physically against the microbes. The T cells recognize an invader by the proteins it creates. This is good, but some food proteins can do the exact same thing as if by accident. The immune systems of many people also produce interferon-γ from gluten fragments, ostensibly having confused it with an invading pathogen. The immune system reacts to a good many peptides from foods, but only the ones with enzyme-resistant proline fragments have much of a chance of entering the body—such as those from gluten and casein. Seen in this way, the only thing toxic about gluten is its inability to be digested.* Sourdough bacteria have been shown to cleave these proline bonds, as has the supplemention with prolyl endopeptidase capsules; both of these have been shown to make gluten safe to eat and non-immunogenic.

Interferon-γs from Leishmania, Denge fever, or tropical sprue are indistinguishable from the interferon-γ seen after gluten ingestion (in some people.)

And lowering dietary linoleic lowers prostaglandins everywhere!

*But wheat flour does have reduced iron particles added which are probably best avoided.

Hey, thanks so much finally done processing this. Will continue onwards, hopefully with results
 
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Hairfedup

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@Hairfucctup if you dont mind me asking, are you by any chance suffer from excessive body hair too?

Yes! Hair on my back, shoulders, and on the inside of my forearms that were never there before and look really out of place. Thighs and calves as well as chest even hairier now. You suppose its estrogen dominance?
 

Murtaza

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Nov 28, 2017
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Yes! Hair on my back, shoulders, and on the inside of my forearms that were never there before and look really out of place. Thighs and calves as well as chest even hairier now. You suppose its estrogen dominance?
It could be estrogen dominance but im more inclined to think it could be a cortisol and prolactin issue. Adrenal hyperactivity causes adrenal's to pump out excess cortisol and that really takes a toll on our mental and physical health. I would suggest trying cypro 1mg two times a day (unless you've tried that already) and maybe take some labs for prolactin and thyroid? Goodluck.
 

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