Dietary Carbohydrates Impair Healthspan And Promote Mortality

Discussion in 'Diet' started by kayumochi, Oct 13, 2017.

  1. kayumochi

    kayumochi Member

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    http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30562-4



    The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.

    Main Text
    It has been known since the 1930s that global reduction of food uptake, so-called calorie restriction, extends the lifespan of rodents, other model organisms, including rhesus monkeys, and possibly humans due to an interacting set of experimentally established mechanisms. By contrast and based on observational coincidence rather than prospective causality, dietary recommendations to maintain human health have selectively focused on reduction of nutritive fats, specifically of saturated triglycerides contained within, since the 1970s. An increasing number of prospective studies in large cohorts of humans in the last two decades have repeatedly questioned this practice but have remained widely unnoticed in the general public and also in major parts of the scientific community.

    Recently, the findings of the PURE study, consisting of >135,000 individuals recruited from 18 countries of different developmental stages worldwide, has been published (Figure 1). Conversely, hyperinsulinemia not only is a hallmark of lifespan-impairing type 2 diabetes, but also specifically promotes malignant growth as reflected by an increased incidence of cancers in diabetics. Notably, while the PURE study could not establish an increase in mortality from cardiovascular causes (see above), the observed increase in global mortality likely is related to the second-frequent cause of death, namely cancers, in states of high-carbohydrate uptake.

    From a therapeutic perspective, if carbohydrates are relevant factors in promoting mortality, then not only reduced uptake of these, but also inhibition of carbohydrate uptake or glucose catabolism should extend lifespan. This has been experimentally tested (Figure 1).

    • (1)
      The conversion of D-glucose into metabolic intermediates, namely glycolysis, can be inhibited by compounds like (the highly efficient but rather toxic) 2-deoxy-D-glucose or (the less efficient but completely harmless) D-glucosamine (GlcN). The latter is widely used to treat arthrosis with the questionable claim of inducing cartilage regeneration. Both compounds have been shown to extend C. eleganslifespan (Figure 1) may offer a promising approach easier to obtain than achieving changes in nutritional habits of the general population.
     
  2. Such_Saturation

    Such_Saturation Member

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    I love how the blogosphere trends always precede the scientific shift. Perhaps those scientists who make fun of alternative health are guilty of a little browsing/fanboyism themselves...
     
  3. Westside PUFAs

    Westside PUFAs Member

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    "Recently, the findings of the PURE study, consisting of >135,000 individuals recruited from 18 countries of different developmental stages worldwide, has been published"

    Not controlled. They could've been eating anything.

    Then they say "did not analyze which specific source of carbohydrates (e.g., sugar/refined carbs versus whole-grain products) may contribute to the detrimental effects of carbs observed"
     
  4. ecstatichamster

    ecstatichamster Member

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    Totally bad study. Third world impoverished people under stress don’t live quite as long as wealthy people in Sweden and Canada. Wow. Who would have thought it.
     
  5. tca300

    tca300 Member

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    Guess I'm on the verge of expiration.
     
  6. Gadsie

    Gadsie Member

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    I don't mean to discredit the theories about biological processes that are described, as they are beyond my understanding, but "Questionnaires" is the keyword in this study. When you "survey" people about their dietary habit you will almost definitely get inaccurate data. People who say they eat "pasta, potatoes, sweets" etc. are probably interpreted to eat high-carb, but then forget that there is at least an equal amount of fat in there in form of sauces, butter etc.
     
  7. Liubo

    Liubo Member

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    This study is brought to you by the agencies that give confused health advice, and the people that they give it to.
     
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