Chaga Mushroom Quinone

[teds]

No. An intuitive feeling of health boosting benefits. Plus I make an amazing ice “tea” with it that is super yummmmmy I simmer the chunks for 2-3 hours with a cinnamon stick. Then strain and add honey, refrigerate and either make a 1/2, 1/2 solution with sparkling water - tastes like a natural root beer soda and/or drink straight. Feels like you are drinking an elixir @ecstatichamster

I just bought chaga chunks specifically to try this recipe lisa! Sounds amazing! I shall report!

 

[lollipop]

I just bought chaga chunks specifically to try this recipe lisa! Sounds amazing! I shall report!

Oh please do! You will love it Even my husband asks about it now. After using the chunks freeze them, and reuse again a few times. Again save them in the freezer. When you have a bunch of them, put in a large jar with alcohol (I used brandy/cognac) for 3-4 months and do an alcohol extraction to release other healing compounds.

 

[ecstatichamster]

I have a chaga water extract powder that I am beginning to test out. Looking forward to it.

 

[energyandstruct]

There are tons of antioxidant related papers so I decided to focus on other aspects. I just used Pubmed and Google Schoolars and searched on Chaga, Betulenic Acid and some on Superoxide Dismutase.


Chaga


Cancer/Energy/Bodytemperatur

Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice. - PubMed - NCBI

Increased muscle and liver glycogen

Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice. - PubMed - NCBI

Lung Cancer

Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in... - PubMed - NCBI

Glycation/Diabetes/Kidney

Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosi... - PubMed - NCBI

Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt sign... - PubMed - NCBI

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-indu... - PubMed - NCBI

Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in ... - PubMed - NCBI

Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice. - PubMed - NCBI

Anti-Viral

Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. - PubMed - NCBI

Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts. - PubMed - NCBI

Alcohol

Effects of the herb mixture, DTS20, on oxidative stress and plasma alcoholic metabolites after alcohol consumption in healthy young men. - PubMed - NCBI

Colorectal Cancer

Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line. - PubMed - NCBI

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal... - PubMed - NCBI

Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells. - PubMed - NCBI

Liver

Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxi... - PubMed - NCBI



Betulenic Acid


Anti-estrogen

Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina - ScienceDirect

Anti-Bacterial

In Vivo Anti-Inflammatory, Anti-Bacterial and Anti-Diarrhoeal Activity of Ziziphus Jujuba Fruit Extract. - PubMed - NCBI

Microbial cyclic β-(1→3),(1→6)-glucans as potential drug carriers: Interaction studies between cyclic β-glucans isolated from Bradyrhizobium japoni... - PubMed - NCBI

cAMP

Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permane... - PubMed - NCBI

Brain

Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possib... - PubMed - NCBI

Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation. - PubMed - NCBI

Liver Health

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway - ScienceDirect

http://rabbit.if-pan.krakow.pl/pjp/pdf/2005/5_588.pdf

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.2010.01239.x

Viral

Synthesis of three triterpene series and their activity against respiratory syncytial virus. - PubMed - NCBI

SERCA plays a crucial role in the toxicity of a betulinic acid derivative with potential antimalarial activity. - PubMed - NCBI

Cancer

https://www.sciencedirect.com/science/article/pii/S0304383501007182

https://europepmc.org/abstract/med/15057642

Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo. - PubMed - NCBI

Prostate

https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.20447

Targeting SP1 Transcription Factor in Prostate Cancer Therapy: Ingenta Connect

Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-Specific Apoptosis: Possible Role for Inhibition of Deubiquitinase Activity

http://www.jbc.org/content/early/2004/12/02/jbc.M409477200.full.pdf

Melanoma

https://www.nature.com/articles/nm1095-1046

Breast

https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.21893

http://mct.aacrjournals.org/content/early/2012/06/23/1535-7163.MCT-12-0026.short

Brain

https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1097-0215(19990730)82:3<435::AID-IJC18>3.0.CO;2-1

Aids HIV

https://pubs.acs.org/doi/abs/10.1021/np50104a008?journalCode=jnprdf

https://onlinelibrary.wiley.com/doi/abs/10.1002/med.10053

https://www.ingentaconnect.com/content/ben/cmc/2005/00000012/00000006/art00003

https://pubs.acs.org/doi/abs/10.1021/jm950922q?journalCode=jmcmar

https://www.ncbi.nlm.nih.gov/pubmed/29631960


Superoxide Dismutase


Aging

http://science.sciencemag.org/content/263/5150/1128

http://science.sciencemag.org/content/289/5484/1567

https://www.sciencedirect.com/science/article/pii/0891584994900809


I do not have the knowledge to confirm these papers as legit information! I just want to give this potentially great supplement some spotlight!

Chaga has "over 215 phytonutrients, glyconutrients including: Betulinic Acid, Polysaccharides, Beta Glucans, Tripeptides, Triterpenes including Lanosterol-type Triterpenes, Sterols, Saponins, Inotodiols, Trametenolic Acid and Melanin."

Chaga is tremendous in nutrients and positive effects. I would love to ask Peat about it but I do not have his e-mail

@haidut even has a standalone Lanosterol supplement.

I have very severe CFS and have found suprrisingly good results from very strong chaga tea. I tend to wake up the next day with nausea tho. I don't know if that's a bad sign> I'd like to try and understand what's going on with the chaga causing temporarily relief and see if i can get this from other things too

 

[Anders86]

I have very severe CFS and have found suprrisingly good results from very strong chaga tea. I tend to wake up the next day with nausea tho. I don't know if that's a bad sign> I'd like to try and understand what's going on with the chaga causing temporarily relief and see if i can get this from other things too

Thats great!
Remember SOD and Betulenic Acid is best absorbed sublingual from alcohol extract.

Nausea could be some toxin release from liver. I notice slight anxiety first time I take it after a break. I have read some people also get this from coffee.

 

[lollipop]

Thats great!
Remember SOD and Betulenic Acid is best absorbed sublingual from alcohol extract.

Nausea could be some toxin release from liver. I notice slight anxiety first time I take it after a break. I have read some people also get this from coffee.

@Anders86 is correct @debored13. You want to have both water and alcohol extraction to cover all the healing bases. I noticed it is possible to buy a tincture of it with both water and alcohol extraction in the tincture. That might be a way to go for speed and ease.

 

[energyandstruct]

Thats great!
Remember SOD and Betulenic Acid is best absorbed sublingual from alcohol extract.

Nausea could be some toxin release from liver. I notice slight anxiety first time I take it after a break. I have read some people also get this from coffee.

hmm source for the toxin release thing? I remember ray saying something about the "detox" stuff a lot of alternative health ppl push as not being true, that the liver simply breaks down toxins, except fatty liver

 

[energyandstruct]

Thats great!
Remember SOD and Betulenic Acid is best absorbed sublingual from alcohol extract.

Nausea could be some toxin release from liver. I notice slight anxiety first time I take it after a break. I have read some people also get this from coffee.

it is good but the effects are only there very transiently as with a few other things i've tried. i don't expect it to cure me but i feel (relatively) good just from pain relief in that short window. would love to figure out what or why this is happening... like what in the chaga is responsible for it. I know it's supposedly helping with autoimmunity according to some sources, also has oxalic acid among other things.. i feel like if i could figure out why it's working i could figure out what's making me so sick and reverse engineer it... but it's tricky

 

[Anders86]

hmm source for the toxin release thing? I remember ray saying something about the "detox" stuff a lot of alternative health ppl push as not being true, that the liver simply breaks down toxins, except fatty liver

No sources only anecdote as I get the same feeling when I take a break from coffee. Both Coffee and Chaga would be considered a liver tonic. But your nausea might be something else, it was just a quick thought.

 

[energyandstruct]

No sources only anecdote as I get the same feeling when I take a break from coffee. Both Coffee and Chaga would be considered a liver tonic. But your nausea might be something else, it was just a quick thought.

ah ok. i don't get bad effects from coffee. will keep experimenting. thanks for the thoughts

 

[energyandstruct]

Didn't get many effects from tinctures, maybe not strong enough

Or maybe chaga just stoped working for me

 

[energyandstruct]

Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus - ScienceDirect

 

[energyandstruct]

Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice. - PubMed - NCBI

 

[energyandstruct]

chaga also contains a peptide that inhibits platelet aggregation and I may have gotten some bruising from it

 

[Inaut]

Any thoughts on the high oxalate content of Chaga? Any need for concer?

 

[RealNeat]

Any thoughts on the high oxalate content of Chaga? Any need for concer?

Just add a little milk and make a chaga latte

 

[Experienced]

Still no answer from @haidut ?

 

[Experienced]

I have local alcohol extract available that I use sublingual. And nothing picks me up like Chaga mushroom. Mental energy and mood rises, cortisol lowers, edema sweats away, liver feels great and stomach shrinks. My only "concern" is what it does to my androgens. I`m researching this now but hard to find concrete information. Super Oxidase Dismutase and Betulenic Acid seem to be key opponents..

 

[Anders86]

View attachment 15221

Nice one! Even though I would like some scientific backing from his claims about triterpenes. I have also seen some healthy critique on SOD from tommolittlewood on his Instagram.

 

[Experienced]

Nice one! Even though I would like some scientific backing from his claims about triterpenes. I have also seen some healthy critique on SOD from tommolittlewood on his Instagram.

People also say bs about chaga or othermushrooms without backing up with scientific evidence that it worsens HIV and AIDS Haidut once posted a thread on here that beta glucans were able to increase hiv aids processing. Don't know which thread exactly.

Candida Overgrowth Is A Major Factor In (alcoholic) Liver Damage / Cirrhosis