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Brain Insulin Resistance Identified As Possible New Link Between Alzheimer's Disease, Diabetes

Discussion in 'Articles & Scientific Studies' started by paymanz, Feb 8, 2017.

  1. paymanz

    paymanz Member

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    It says brains inability to burn glucose is responsible for Alzheimer's disease.caused by insulin's resistance in brain, and that probably mediated by inflammation.

    Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's Disease – PR News

    https://www.hindawi.com/journals/mi/2015/105828/

    Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition. As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.

    http://www.sciencedirect.com/science/article/pii/S155252601302918X

    Compelling preclinical and clinical evidence supports a pathophysiological connection between Alzheimer's disease (AD) and diabetes. Altered metabolism, inflammation, and insulin resistance are key pathological features of both diseases. For many years, it was generally considered that the brain was insensitive to insulin, but it is now accepted that this hormone has central neuromodulatory functions, including roles in learning and memory, that are impaired in AD. However, until recently, the molecular mechanisms accounting for brain insulin resistance in AD have remained elusive. Here, we review recent evidence that sheds light on how brain insulin dysfunction is initiated at a molecular level and why abnormal insulin signaling culminates in synaptic failure and memory decline. We also discuss the cellular basis underlying the beneficial effects of stimulation of brain insulin signaling on cognition. Discoveries summarized here provide pathophysiological background for identification of novel molecular targets and for development of alternative therapeutic approaches in AD

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    Blocking Inflammation From PUFA Reverses Brain Aging

    JNK And Tumor Necrosis Factor-alpha Mediate Free Fatty Acid-induced Insulin Resistance In 3T3-L1 Adi
     
  2. Koveras

    Koveras Member

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    "type 3 diabetes" - PubMed - NCBI
     
  3. OP
    paymanz

    paymanz Member

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  4. Peater Piper

    Peater Piper Member

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    There's been some research in bypassing the problem with ketones, either through diet or using large amounts of MCTs. Correcting the insulin resistance would be ideal, though.
     
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