Andy Milonakis Metahuman? Ray Peat Vindicated?

[ilikecats]

Here are some pictures of actor Andy Milonakis who was born with a growth hormone deficiency. He is 42 years old, both of these pictures have been taken recently. Felt like having some fun with the title lol. In case you aren't familiar for the most part growth hormone is viewed very positively in mainstream medicine. I remember when I first got into health and nutrition I spent a lot of time researching ways to increase growth hormone. I was pretty shocked to find that Ray Peat viewed growth hormone so negatively for the most part. But now even mainstream medicine is starting to reverse their views on it. Probably because so many people have been experimenting with it as an anti aging therapy and have encountered terrible side effects.
"Controversies surrounding the potential utility of GH in treatment of a geriatric patient are fueled by increasing evidence linking GH and cancer and by remarkably increased lifespan of GH-resistant and GH-deficient mice"-
Growth hormone and aging: A challenging controversy

 

[Wagner83]

Damn, no more sprints or intermittent fasting.

 

[Blossom]

He looks like a teenager.

 

[tara]

I'd be curious about how he'll be in 50-100+ years, but I probably won't be around to see. :)

 

[Such_Saturation]

 

[Dhair]

Suppress dat pituitary

 

[Mukem]

What's the average lifespan of people with this condition? The studies mentioned mutant rats with increases in lifespan ranging from 25-60%. One of the symptoms of growth hormone deficiency is supposed to be increased weight. Andy's body composition certainly doesn't look very desirable. He looks like an unhealthy teenager.

 

[tara]

What's the average lifespan of people with this condition? The studies mentioned mutant rats with increases in lifespan ranging from 25-60%. One of the symptoms of growth hormone deficiency is supposed to be increased weight. Andy's body composition certainly doesn't look very desirable. He looks like an unhealthy teenager.

I'm curious too. The average pudgy teenager can expect to live a few decades longer into the future than the average forty-something-year old, however 'healthy' he looks.

 

[Mukem]

"One study reported markedly reduced longevity of individuals with congenital GH deficiency (Besson et al 2003) while other workers reported that both GH-deficient and GH-resistant subjects can reach very advanced age, are protected from cancer and, interestingly, are also protected from atherosclerosis and vascular pathology in spite of obesity and unfavorable serum lipid profiles (Krzisnik et al 1999; Laron 2005; Menezes Oliveira et al 2006; Shechter et al 2007; Shevah and Laron 2007)."

"Pathological hypersecretion of GH in patients with gigantism and acromegaly reduces life expectancy due to increased incidence of cardiovascular disease, diabetes and, in acromegalics, apparently also cancer (Jadresic et al 1982; Orme et al 1998). The question whether the rate of aging is affected by acromegaly has apparently never been addressed. A series of elegant studies by Sacca and colleagues (Sacca et al 1994, 2003) provided evidence that both GH deficiency and GH excess are detrimental for cardiac function in the human with GH-deficient patients benefiting from GH therapy and acromegalics benefiting from suppression of GH levels. Another possible reason for the complex relationship between somatotropic signaling and human longevity was provided by results of genetic studies which indicated that reduced IGF-1 levels protect from some age-related diseases but increase the risk of others (Lamberts et al 1997)."

"How can we summarize the present understanding and use this information to suggest possible anti-aging interventions? Physiological action of the amounts of GH normally secreted by the pituitary is critically needed for growth and maturation and enhances reproductive potential but may also limit life expectancy. Somatotropic signaling can be suppressed by modest calorie restriction (Masoro 2001). Well-documented beneficial effects of calorie restriction on longevity of many species and on important predictors of life expectancy in humans (Heilbronn et al 2006; Holloszy and Fontana 2007) suggest that subtle, long-term reduction in GH release and/or activity may have a potential to slow aging, protect from age-related disease and increase lifespan. However, the symptoms of congenital or acquired GH-deficiency clearly indicate that severe or complete suppression of GH actions can not be recommended or even seriously considered for enhancement of human longevity."

The Besson study :

"Increased longevity of hypopituitary dwarf mice and GH- resistant knockout mice appears to be in contrast with observations made in clinical practice. In humans, on one hand hypopituitarism and GH deficiency (GHD) are believed to constitute risk factors for cardiovascular disease and, therefore, early death. But on the other hand, patients with a PROP-1 gene mutation, presenting with a combined pituitary-derived hormonal deficiency, can survive to a very advanced age, apparently longer than normal individuals in the same population. The aim of this study was to analyze the impact of untreated GHD on life span. Hereditary dwarfism was recognized in 11 subjects. Genetic analysis revealed an underlying 6.7-kb spanning deletion of genomic DNA encompassing the GH-1 gene causing isolated GHD. These patients (five males and six females) were never treated for their hormonal deficiency and thus provide a unique opportunity to compare their life span and cause of death directly with their unaffected brothers and sisters (11 males and 14 females) as well as with the normal population (100 males and females). Although the cause of death did not vary between the two groups, median life span in the GH-deficient group was significantly shorter than that of unaffected brothers and sisters [males, 56 vs. 75 yr (P < 0.0001); females, 46 vs. 80 yr (P < 0.0001)]. Therefore, with the wealth of information regarding the beneficial effects of GH replacement and the dramatic findings of this study, GH treatment in adult patients suffering from either childhood- or adult-onset GHD is crucially important."

Reduced longevity in untreated patients with isolated growth hormone deficiency. - PubMed - NCBI

 

[Such_Saturation]

"One study reported markedly reduced longevity of individuals with congenital GH deficiency (Besson et al 2003) while other workers reported that both GH-deficient and GH-resistant subjects can reach very advanced age, are protected from cancer and, interestingly, are also protected from atherosclerosis and vascular pathology in spite of obesity and unfavorable serum lipid profiles (Krzisnik et al 1999; Laron 2005; Menezes Oliveira et al 2006; Shechter et al 2007; Shevah and Laron 2007)."

Gotta love that solid clinical science that we all can trust

 

[HealthisWealth]

Nice humor with the thread title.

The tv series The Flash will return two weeks from now.

 

[johnwester130]

Lionel Messi also had a growth hormone deficiency.

He also has mild autism.

Lionel Messi's improbable progression from struggling youngster to world super star

Is there a connection between autism and hormonal profile ? Autistic people look different

 

[cyclops]

He should cut.

 

[lvysaur]

Is there a connection between autism and hormonal profile ? Autistic people look different

I have read that undermethylators are more likely to be autistic. Not sure how reliable that info is.

 

[baccheion]

Lower (but still in range) IGF-1 is said to lengthen lifespan in rats.

 

[Evgenius]

Someone should definitely ask Ray if purposely lowering GH is beneficial.

 

[shepherdgirl]

 

[BigYellowLemon]

Yeah I've been curious why Andy Milonakis has such nice skin, when HGH is said to make on look younger. Makes no sense.

 

[shepherdgirl]

In the video above Dr Peat says GH "can interfere with oxygen metabolism." Why does GH have the reputation of burning body fat if it interferes with oxygen metabolism? Many paleo guys are super lean. Sugar eaters, otoh..... not so much.

 

[Evgenius]

Many paleo guys are super lean. Sugar eaters, otoh..... not so much.

They are lean because cortisol makes you loose weight.