bdawg
Member
Re: Negative feedback
Androsterone seems to lower androgen synthesis through activation of FXR, independently of the typical negative feedback loop (via GNRH/LH)
Bile acids and male fertility: From mouse to human?
View attachment 9209
@Koveras, transdermal androsterone should get metabolised on impact is what im thinking
Either to 5a-androstanedione (which then converts to DHT) or other metabolites (see below)
The Metabolism of 5α-Dihydrotestosterone and Androsterone by Skin
Or to androstanediol via skin 17 beta HSD which also converts to DHT
Thoughts?