Androgens (DHT, T) Treat Prostate Cancer, Especially When Combined With Vitamin D

[TreasureVibe]

OVERVIEW
Over 80% of patients with prostate cancer respond to androgen deprivation using drugs or surgery that marked reduce male sex hormone (testosterone) and related androgen levels from the body. Anti-androgens are a class of drugs that specifically block the entry of testosterone into cells of the body, thus preventing its biological effects. Examples of such drugs that are available on the U.S. market include flutamide (Eulexin®), bicalutamide (Casodex®) and nilutamide (Nilandron™). Cyproterone (Androcur) is another anti-androgen that is not available in the U.S.

In approximately 50% of patients whose cancer has started to grow again despite treatment that includes an antiandrogen, the cancer has been noted to regress by simply stopping the anti-androgen. This unusual response is referred to as the Anti-Androgen Withdrawal Response (AAWR). Scientists theorize that prostate cancer cells exposed to antiandrogens for a prolonged time may mutate (undergo genetic change) that paradoxically causes the anti-androgen to stimulate cancer growth.

Although more research is needed, we believe a trial of stopping the anti-androgen for a period of time is warranted in order to determine whether or not an AAWR may occur before considering other types of treatment. A review of the scientific studies that support this treatment approach follows below:

The anti-androgen withdrawal response (AAWR) may be seen, in up to 50% of patients who have PSA relapse while receiving androgen blockade. An AAWR response usually lasts 6 to 8 months, but for some patients, may last as long as 2 years.

Source: " AAWR" THE ANTI-ANDROGEN WITHDRAWAL RESPONSE


A R T I C L E


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"...simultaneous treatment of intact...rats with testosterone and estradiol-17beta for 16 weeks consistenly induced a putative precancerous lesion, termed dysplasia, in the dorsolateral prostate of all animals. Since treatment of rats with androgen alone did not elicit the same response, we concluded that estrogen played a critical role in the genesis of this proliferative lesion." Shuk-mei Ho and M. Yu, in "Selective increase in type II estrogen-binding sites in the dysplastic dorsolateral prostates of Noble rats," Cancer Research 53, 528-532, 1993.

Source: Ray Peat article on Prostate Cancer

 

[TreasureVibe]

The doctor was asked why the avodart prescription, and why "too much testosterone" is the problem when younger men have more. His answer, for the record, was that the swollen prostate provides more testosterone receptors due to its larger size, hence effectively more testosterone reaching and acting on the prostate. He is a leading urologist (spell predictor keeps wanting to say ufologist and maybe that's more accurate) so there's the official line for you.

Source: Summary Of Prostate Improvements

 

[Obi-wan]

I actually stopped taking Firmagon in July of last year. By October last year my PSA was back to 13,000...so that didn't work...

 

[TreasureVibe]

I actually stopped taking Firmagon in July of last year. By October last year my PSA was back to 13,000...so that didn't work...

Posted 02 Apr 2017 at 14:35

75 sounds bad until you realise that we have members on here whose PSA was 6000, 8000 and in one case 13,000 at diagnosis and all are still here some years later! PSA is an indicator that there is a problem but is not a reliable judge of whether it is indeed cancer or how far it might have spread. My husband had a PSA of 3.1 but it had already spread into his bladder, we had a member join recently with a PSA of over 100 but he turned out to have no cancer, just a very enlarged prostate.

I am afraid though that the fact they have told dad it is advanced prostate cancer (PCa) indicates that they have reason to believe it has already spread somewhere - that's what 'advanced' means. Now, it may be that they are just guessing - PCa cannot usually be diagnosed for sure until a biopsy is done - or that they suggested it might be advanced PCa and dad heard the scary words only. Or it may be that on the scans they have already seen that there is a tumour outside the gland or on the bones and the biopsy is only to determine which type of cancer it is (there are at least 27 different types of PCa). It might be that the blood tests are indicating that the bones are affected, or possibly the signs / indicators that caused him to go to the doctor are so strong that it is obviously PCa. The other possibility is that he has misheard - could they have said it was 'aggressive' rather than 'advanced'? The two words both sound terrifying but aggressive does not mean what it sounds like when describing PCa.

Can you tell us a bit more about why he was tested in the first place?

I know it is hard not to panic but if he has been told it is advanced, there are usually treatments that can slow it down and keep him with you for many years yet.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

Source: Psa level of 75 - Start here! - Prostate Cancer UK Online Community

That forum recommends biopsy. Biopsy or any other test that takes a physical piece of the tumor in some way, could cancer to spread, metastasize or grow etc, perhaps, with an emphasis on perhaps (it is unclear but the study is shocking). Or it was a chemotherapy study, or radiatino study. I can't find the thread right now. I can find the following thread:

Chemotherapy Causes Cancer Metastases, Tumor Evolution

With the following quote by burtlancast, which does mention surgery.

Both chemotherapy , radiotherapy AND surgery have long been known to enhance tumor spreading in the long term.

Eli Jones (1850-1933) recognized surgery was detrimental to the cancer patient, and used cancer herbal salves to achieve outstanding cure rates.
In 1911, before retiring, he compiled a book about his methods: Cancer - Its Causes, Symptoms and Treatment (free to download at archive.org: Cancer: Its Causes, Symptoms & Treatment, Giving the Results of Over Forty ... : Eli G Jones : Free Download, Borrow, and Streaming : Internet Archive)
Eli Jones - Wikipedia

Today, cancer specialists scare the bejesus out of you and don't give you any reflection time. 85% of people cannot manage their own health and would never distrust a doctor.

The bigger the lie, the more believable.

There's a lot of deliberate misinformation on the net about alternative cancer therapies, just as there a lot of excellent info.

The problem is having the time to sift through it (while you're dying).

I don't know, I am just very conservative at this point if I read in a topic by Haidut that cancer surgery causes metastasis.

 

[Obi-wan]

Had the biopsy, had the Gleason Score, had the bone scan, Torso bones were light up on the x ray. Like I said I had a meeting with the Grim Reaper. The Lord intervened...

 

[TreasureVibe]

Had the biopsy, had the Gleason Score, had the bone scan, Torso bones were light up on the x ray. Like I said I had a meeting with the Grim Reaper. The Lord intervened...

I'd still inquire professionals before embarking on the potassium ascorbate tho... And ask with full conviction, wether or not it could screw something up that is not supposed to get screwed up in your specific case. And even then, I would still doubt.

Some interesting information: Cortisol: A Hormone Associated With Prostate Cancer

 

[TreasureVibe]

Maybe any hormone or blend of hormones can cause cancer in the prostate, when given enough through failing veins that cause backflow. Or more compounds, perhaps secreted from the prostate itself, flow back into it and accumulate there due to failing veins.

Perhaps these prostate secretions, in combination with aforementioned blend of hormones could even cause cancer.

Function[edit]
Male sexual response[edit]
Main article: Prostate massage
During male seminal emission, sperm is transmitted from the vas deferens into the male urethra via the ejaculatory ducts, which lie within the prostate gland. Ejaculation is the expulsion of semen from the urethra. It is possible for some men to achieve orgasm solely through stimulation of the prostate gland, such as prostate massage or anal intercourse.[18][19][20]

Secretions[edit]
Prostatic secretions vary among species. They are generally composed of simple sugars and are often slightly alkaline.[21] In human prostatic secretions, the protein content is less than 1% and includes proteolytic enzymes, prostatic acid phosphatase, beta-microseminoprotein, and prostate-specific antigen. The secretions also contain zinc with a concentration 500–1,000 times the concentration in blood.

Regulation[edit]
To function properly, the prostate needs male hormones (androgens), which are responsible for male sex characteristics. The main male hormone is testosterone, which is produced mainly by the testicles. It is dihydrotestosterone (DHT), a metabolite of testosterone, that predominantly regulates the prostate.

Source: Prostate - Wikipedia

Also genes could still, as an exception perhaps, play a role in prostate cancer problems:

Gene and protein expression[edit]
Further information: Bioinformatics § Gene and protein expression
About 20,000 protein coding genes are expressed in human cells and almost 75% of these genes are expressed in the normal prostate.[22][23] About 150 of these genes are more specifically expressed in the prostate with about 20 genes being highly prostate specific.[24] The corresponding specific proteins are expressed in the glandular and secretory cells of the prostatic gland and have functions that are important for the characteristics of semen. Examples of some of the most prostate specific proteins are enzymes, such as the prostate specific antigen (PSA), and the ACPP protein.

 

[TreasureVibe]

"The problem is that a biopsy or the prostate “removal” operation can cause a dormant cancer to spread through the rest of the body."

Source: 4 Early Warning Signs of Prostate Cancer: Understanding Prostate Cancer Symptoms

I don't necessarily endorse the views of that website. But sure is an interesting read.

 

[TreasureVibe]

Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction. - PubMed - NCBI

 

[TreasureVibe]

Effects of coconut oil on testosterone-induced prostatic hyperplasia in rats, coconut oil significantly lowered prostate weight and prostate weight/body weight ratio in testosterone-induced prostatic hyperplasia in rats: https://onlinelibrary.wiley.com/doi/abs/10.1211/jpp.59.7.0012

Haidut post on prostate cancer cells expressing aromatase:

So, this is what the medical industry has gotten to. After its therapies on androgen deprivation failed, and then an androgen paradoxically treats the very condition it is supposed to cause what does a cunning pharma exec or clueless doctor do? Claim that the androgen converts into estrogen and this is how it treats the condition. First of all, giving high dose T injections raises BOTH estrogen and T. Anybody who claims giving T will do nothing but raise estrogen needs to re-attend medical school. Second, giving T injections raises T a lot more then it raises estrogen. Third, it raises DHT a lot more than it raises estrogen. Remember, DHT is the "evil" guy in prostate cancer. So any increase of DHT (and T) should have led to rapid progression but instead it put these men into remission. And if estrogen was truly the beneficial hormone why not simply give high dose oral DHEA, which is probably the most effective oral estrogen precursor!? Oh, wait, it was tried and actually made the cancer worse. Wow, how sick the medical industry has become. It will do anything but face the idiocy in its own thinking.
Oh, and last but not least - the direct estrogen therapy has been tried many times before. You know what it does - it kills the person by stroke or heart attack, so that the death can be attributed to other causes and estrogen is in the clear and can continue to be prescribed for cancer.
Anyways, here is yet another study showing that aggressive prostate cancer is due to a "new" type of estrogen receptor and that prostate cancer cells express aromatase more than any other enzyme, including 5-AR.
http://www.fasebj.org/cgi/content/meeting_abstract/20/4/A221-b
"...Prostate cancer is the second leading cause of cancer mortality in American males. Although early diagnosis and treatment have been proven to be efficacious, a significant portion of these tumors metastasize to remote sites resulting in death. While the role of androgens in prostate cancer progression has been well characterized the role of estrogens is still unclear. Prostate cancer cells express aromatase (CYP19) which converts androstenedione to estradiol, thus providing a rationale for estrogen playing a role in prostate cancer biology. Previous studies have focused on the classical estrogen receptors (

and ß) in prostate cancer growth and metastases. Recently a novel membrane bound G-protein coupled estrogen receptor, GPR30, has been identified and shown to regulate rapid intracellular signaling events in breast cancer cells. The purpose of this study was to determine if GPR30 is expressed in prostate cancer cell lines that exhibit differing degrees of invasiveness. Prostate cancer cells LnCap, PC-3 and DU-145 were grown in serum supplemented media, harvested and analyzed by western blot with an antibody directed GPR30. Our results demonstrate that the invasive cell lines PC-3 and DU-145 express GPR30 while less invasive LnCap cells showed no expression. This study is the first to demonstrate that GPR30 is expressed in aggressive prostate cancer cell lines. The role of GPR30 in the regulation of prostate cancer growth remains to be determined. Interestingly, GPR30 has two splice variant sites that may have functional significance in the differing reports on the action of estrogens in prostate cancer. In conclusion, GPR30 may represent a new therapeutic target in aggressive prostate cancers."

Regardless of how much these goons deny that T (and DHT) was the direct therapeutic agent, the cat is out of the bag. So, it does not really matter if the official "mechanism of action" is claimed to be estrogen through aromatization of T, lives will be saved regardless. Finally, if there is ANY benefit in estrogen therapy it is because it actually...wait for it...increased DHT in humans with prostate cancer.
The mechanism of action of estrogen in castration-resistant prostate cancer: clues from hormone levels. - PubMed - NCBI
"...CONCLUSION: Androgens decline in response to estrogen therapy. A decline in DHEA-S and a rise in DHT are both associated with a decline in PSA while patients receive estrogen therapy."