Amphetamines And Nicotine

[DaveFoster]

My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

 

[mujuro]

According to wikipedia, only methamphetamine is neurotoxic. The editor uses the term "directly" neurotoxic. Anyone know what this means? First line: https://en.wikipedia.org/wiki/Methamphetamine#Neurotoxicity_and_neuroimmune_response

On the page for amphetamine, someone has written that "in sufficiently high doses" amphetamine induces dopaminergic neurotoxicity.

What about methylphenidate? I've only tried it once - definitely keeps you glued to a single task for hours on end but like amphetamines I don't think it's a practice that can be sustained without experiencing downregulations or depletions.

 

[DaveFoster]

What about methylphenidate? I've only tried it once - definitely keeps you glued to a single task for hours on end but like amphetamines I don't think it's a practice that can be sustained without experiencing downregulations or depletions.

Methylphenidate seems to be the most mild of the amphetamine salts; it even has neuroprotective effects when paired with very low doses of methamphetamine. Ray Peat views the amphetamines to work similarly to estrogen and choline; they enhance concentration and memory in the short-term, but at the cost of long-term damage.

 

[tobieagle]

Low dose LSD synergises nicely with caffeine.
But if the work is too boring it could distract you.

 

[FredSonoma]

post 112999 My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

What is choline / what is bad about it being raised?

 

[answersfound]

My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

I would go with pregnenolone in high doses.

 

[Parsifal]

My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

I would go with pregnenolone in high doses.

What if it gives you headaches and makes you feel groggy (clean sup, haidut's one)? I need to be able to concentrate well for school but I have ADD and lack will...

 

[answersfound]

post 113074

My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

I would go with pregnenolone in high doses.

What if it gives you headaches and makes you feel groggy (clean sup, haidut's one)? I need to be able to concentrate well for school but I have ADD and lack will...

I'm not sure. Maybe your not doing it with enough food. ADD and low will power is caused by low thyroid, running on stress hormones. So you should adress that first and establish a foundation, before you look to enhance performance.

 

[DaveFoster]

quote="tobieagle"]post 113070 Low dose LSD synergises nicely with caffeine.
But if the work is too boring it could distract you.[/quote]
Definitely agree with this; I'll try hydergine and see how it compares when my shipment gets here.

I'm not sure. Maybe your not doing it with enough food. ADD and low will power is caused by low thyroid, running on stress hormones. So you should adress that first and establish a foundation, before you look to enhance performance.

I will try out pregnenolone. Caffeine's appetite-supressing effects are unbelievably annoying. It causes one to eat about half as much as ideal. I hope it evens out when my body fat lowers, else it's time for the cyproheptadine megadoses.

 

[michael94]

post 113070 Low dose LSD synergises nicely with caffeine.
But if the work is too boring it could distract you.

my vote as well

the adderall is more suited for making you into a machine to do the actuarial stuff

however, please do read this https://cogumelosmagicos.org/comunidade ... pdf.48498/ starting at page 220 through 233

 

[DaveFoster]

Anyone have any experiences with methylphenidate? It seems to be safer than amphetamine and their derivatives.

Interesting Vyvanse includes a derivative of L-lysine.

 

[tyler]

Anyone have any experiences with methylphenidate? It seems to be safer than amphetamine and their derivatives.

Interesting Vyvanse includes a derivative of L-lysine.

It was long ago now, but I started on Ritalin and then concerta and they both caused me servere stomach distress. I soon after switched to the amphetamine class and didn't experience the pain anymore.

 

[DaveFoster]

It was long ago now, but I started on Ritalin and then concerta and they both caused me servere stomach distress. I soon after switched to the amphetamine class and didn't experience the pain anymore.

Thanks for the reply. It seems that methylphenidate doesn't have the same effect on serotonin as amphetamine.

Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. - PubMed - NCBI

 

[lampofred]

My motivation seems to be tailing off; I'm becoming less social and more focused on my studies, which is necessary in my situation.

I need something that will make me into a machine; something capable of performing long hours of actuarial work without rest.

Amphetamines are neurotoxic. Nicotine raises choline. Modafinil raises histamine. I'm working up to 5g of caffeine per day, so this is out as well. I will try hydergine; an ergot-derivative that will raise dopamine and lower serotonin.

What else is there? I'm looking for motivation and mood; something that doesn't raise serotonin, choline, or histamine, but allows me to feel psychologically motivated to do work.

Were you able to find something that works for you? I have the same issue in that I'm already at high doses of caffeine which I can't increase any more. I have a Vyvanse prescription, but I don't want to take it because 1) I think stimulants are a clumsy way to treat ADHD, 2) Peat says amphetamines are as harmful as estrogen, and 3) taking Vyvanse works temporarily but makes me feel like absolute crap the next day.

Peat says CO2 is important for frontal lobe growth and executive functioning, so I've been trying bag-breathing. But clearly it's not working considering how I'm still on this website instead of working...

 

[DaveFoster]

Were you able to find something that works for you? I have the same issue in that I'm already at high doses of caffeine which I can't increase any more. I have a Vyvanse prescription, but I don't want to take it because 1) I think stimulants are a clumsy way to treat ADHD, 2) Peat says amphetamines are as harmful as estrogen, and 3) taking Vyvanse works temporarily but makes me feel like absolute crap the next day.

Peat says CO2 is important for frontal lobe growth and executive functioning, so I've been trying bag-breathing. But clearly it's not working considering how I'm still on this website instead of working...

Do you watch porn or play video games, and have you had your TSH checked?

 

[Constatine]

Were you able to find something that works for you? I have the same issue in that I'm already at high doses of caffeine which I can't increase any more. I have a Vyvanse prescription, but I don't want to take it because 1) I think stimulants are a clumsy way to treat ADHD, 2) Peat says amphetamines are as harmful as estrogen, and 3) taking Vyvanse works temporarily but makes me feel like absolute crap the next day.

Peat says CO2 is important for frontal lobe growth and executive functioning, so I've been trying bag-breathing. But clearly it's not working considering how I'm still on this website instead of working...

A high mineral diet, especially a diet high in zinc, is effective for adhd.

 

[lampofred]

A high mineral diet, especially a diet high in zinc, is effective for adhd.

I eat beef literally every day, often multiple times a day. No dietary changes I have made have ever had any impact on my ADHD, except that whenever I "fully Peat" (meaning I extremely rigorously stick to 2 quarts milk/1 quart OJ/1 egg/coconut oil/etc.) my symptoms get even worse.

 

[lampofred]

Do you watch porn or play video games, and have you had your TSH checked?

Got my TSH checked three times, and it has always been between .8 and 1.3 when I'm not supplementing thyroid even though I have many hypothyroid symptoms, which makes no sense. My FT3 is on the border of low-normal, but for some reason my body won't increase my TSH to increase my T3 levels regardless of dietary changes. Once, I got my thyroid checked in the middle of a few weeks of supplementing desiccated thyroid, and instead of my T3 going up, it remained at the same level as it normally is when I'm not supplementing thyroid and my TSH instead went to .001.

I play no video games and watch no TV, but porn, (and mindless internet browsing/reading in general), unfortunately and very embarrassingly, is my biggest vice... But it's more of a chicken-or-the-egg situation. Whenever I'm on Vyvanse (rarely, when I urgently have to get something done) I have absolutely no desire to watch porn. It's only when I'm depressed that I'm unable to focus on anything no matter how many techniques I try that I use porn as an anti-depressant. But as soon as I begin watching it, I get disgusted with myself and close the window before I ejaculate. I ejaculate around once a week but only when the desire to orgasm gets intense enough that I can't think about anything else if I don't, which means that continuing to abstain would be counterproductive to my ultimate goal of increasing productivity.

All these issues started only after puberty. My focus was so great right before puberty... I would castrate myself in a heartbeat if it would cure my ADHD, but unfortunately, there's no research on that. Becoming a Jesus-like monk but with worldly accomplishments in addition to spiritual accomplishments is my ideal... Maybe I'll just try it, there has to be a first person for everything.

Sorry, I basically gave everyone my life story and way too much information. High serotonin/low dopamine? But I took 10 caffeine pills, so I don't understand how serotonin can still be high...

 

[DaveFoster]

Got my TSH checked three times, and it has always been between .8 and 1.3 when I'm not supplementing thyroid even though I have many hypothyroid symptoms, which makes no sense. My FT3 is on the border of low-normal, but for some reason my body won't increase my TSH to increase my T3 levels regardless of dietary changes. Once, I got my thyroid checked in the middle of a few weeks of supplementing desiccated thyroid, and instead of my T3 going up, it remained at the same level as it normally is when I'm not supplementing thyroid and my TSH instead went to .001.

I play no video games and watch no TV, but porn, (and mindless internet browsing/reading in general), unfortunately and very embarrassingly, is my biggest vice... But it's more of a chicken-or-the-egg situation. Whenever I'm on Vyvanse (rarely, when I urgently have to get something done) I have absolutely no desire to watch porn. It's only when I'm depressed that I'm unable to focus on anything no matter how many techniques I try that I use porn as an anti-depressant. But as soon as I begin watching it, I get disgusted with myself and close the window before I ejaculate. I ejaculate around once a week but only when the desire to orgasm gets intense enough that I can't think about anything else if I don't, which means that continuing to abstain would be counterproductive to my ultimate goal of increasing productivity.

All these issues started only after puberty. My focus was so great right before puberty... I would castrate myself in a heartbeat if it would cure my ADHD, but unfortunately, there's no research on that. Becoming a Jesus-like monk but with worldly accomplishments in addition to spiritual accomplishments is my ideal... Maybe I'll just try it, there has to be a first person for everything.

Sorry, I basically gave everyone my life story and way too much information. High serotonin/low dopamine? But I took 10 caffeine pills, so I don't understand how serotonin can still be high...

Not at all, thank you for sharing! That's great to know that Vyvanse takes away your urge to watch porn! You really don't know how powerful that information is; many go through their whole lives blaming themselves for their addictions, but your statement contributes to a withdrawal of blame against those who suffer from addictions (almost all), so it's really vital that you share information like that.

Cutting out porn should help at least somewhat; even masturbating to climax without porn would be less harmful then even just looking at porn.

Also, the link between ADHD and puberty probably is not causal, and if it is causal, it's just part of your developmental process. Have you ever taken antidepressants, pregnenolone, or progesterone? Pregnenolone and DHEA can help depression, along with plenty of coffee, the carrot salad taken twice to three times per day, and thiamine (B1).

More importantly, do you have any constructive, loving relationships in your life, or a sense of community? These are human needs, and the multiculturalism and political correctness of modernity destroys our sense of self as participants in a collective identity (at least in the West.)

 

[lampofred]

Not at all, thank you for sharing! That's great to know that Vyvanse takes away your urge to watch porn! You really don't know how powerful that information is; many go through their whole lives blaming themselves for their addictions, but your statement contributes to a withdrawal of blame against those who suffer from addictions (almost all), so it's really vital that you share information like that.

Cutting out porn should help at least somewhat; even masturbating to climax without porn would be less harmful then even just looking at porn.

Also, the link between ADHD and puberty probably is not causal, and if it is causal, it's just part of your developmental process. Have you ever taken antidepressants, pregnenolone, or progesterone? Pregnenolone and DHEA can help depression, along with plenty of coffee, the carrot salad taken twice to three times per day, and thiamine (B1).

More importantly, do you have any constructive, loving relationships in your life, or a sense of community? These are human needs, and the multiculturalism and political correctness of modernity destroys our sense of self as participants in a collective identity (at least in the West.)

I'm glad the Vyvanse info is useful! I read that addiction is caused by a lack of dopaminergic activity, but the overstimulation that addictive substances provide further reduces dopamine signaling by downregulating D2 receptors, so it becomes a vicious cycle.

This is what Peat has to say about mental illness and puberty: "The incidence of the attention deficit-hyperactivity disorder is increasing in the US, somewhat faster among girls than boys (Robison, et al.,2002). In schizophrenic teenagers, the brain shrinks, suggesting an interaction of the hormones of puberty with environmental toxins or deficiencies." So I think although the link may not be causal, there may be some worsening of symptoms caused by puberty (especially estrogen)? Estrogen raises prolactin, and elevated prolactin is a sign of reduced D2 signaling, so I think there may be some unexplored relation between estrogen and addiction/focus considering how the obvious inference from the fact that estrogen raises prolactin is that estrogen reduces D2 activity.

I've taken progesterone, drink plenty of coffee regularly, and take B1 regularly, but they don't help with ADHD. I definitely will try the carrot salad, though. I'm reading that endotoxin is a huge contributor to excess serotonin, of which I definitely have many symptoms.

I often feel much better after I have deep conversations with people, but it's very hard for me to move past the "acquaintance" stage with anyone, both with potential romantic interests and just potential close friends. My gut feeling is that this would definitely be the most helpful thing to work on but also the hardest...

Thank you for your detailed reply and advice!