A Novel Therapeutic Approach To Depression Via Supplement With Tyrosine Hydroxylase

[nasibi]

A novel therapeutic approach to depression via supplement with tyrosine hydroxylase

Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. The regulated activity of TH is thought to play a critical role in modulating the functional activity of catecholaminergic neuronal systems in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression. Here we showed that TH, delivered by protein transduction domain (PTD), passed through the blood–brain barrier and entered the neurons. Systemic TH treatment improved the behavioral despair in the forced swim test (FST) and the tail suspension test (TST), the two models widely used to screen the potential anti-depressant efficacy. The results indicated a novel and potential therapeutic use of TH in the depression disorder.

Haidut, any thoughts on bringing this out as a product for research/lab purposes on our mice?

 

[Koveras]

A novel therapeutic approach to depression via supplement with tyrosine hydroxylase

Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. The regulated activity of TH is thought to play a critical role in modulating the functional activity of catecholaminergic neuronal systems in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression. Here we showed that TH, delivered by protein transduction domain (PTD), passed through the blood–brain barrier and entered the neurons. Systemic TH treatment improved the behavioral despair in the forced swim test (FST) and the tail suspension test (TST), the two models widely used to screen the potential anti-depressant efficacy. The results indicated a novel and potential therapeutic use of TH in the depression disorder.

Haidut, any thoughts on bringing this out as a product for research/lab purposes on our mice?

In summary, based on extensive research and clinical testing adamantane and its derivatives so far seem to possess the following properties: HDAC inhibitor (and thus anti-cancer), anti-cortisol, anti-serotonin, pro-dopamine, anti-diabetes, anti-viral, anti-bacterial, anti-excitotoxic, NMDA antagonism (and thus antidepressant), anticholinergic, antihistamine, etc.
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Diamant is a liquid product containing the chemical adamantane. Derivatives of adamantane have been in clinical use for decades are known for their anti-viral, anti-bacterial, pro-dopamine, and anti-excitotoxic properties. More recent studies have discovered that adamantane and its derivatives are one of the most powerful inhibitors of HDAC (in nanomolar concentrations: EC50 = ~70 nM/L) known to man. Also, admantane (and its derivatives) is one of the few known direct stimulators of the enzyme tyrosine hydroxylase and thus a direct stimulator of endogenous dopamine synthesis. In addition, adamantane and its derivatives have been shown to inhibit cortisol synthesis, lower plasma serotonin, histamine, blood glucose, insulin, and inflammatory biomarkers. The extreme lipophilicity of adamantane has led to its use as an absorption enhancer for various drugs delivered topically, orally or even IV and this lipophilicity seems to also dramatically enhance the half-life of the chemical administered together with adamantane. For example, several derivatives of aspirin, indomethacin and testosterone have been synthesized using adamantane as the modifier and the bioavailability and half life increases from a few hours to as long as 8 weeks (i.e. see the liphophilicity links in the references below; the steroid Bolmantalate is a direct example Bolmantalate - Wikipedia). Given these properties, admantane may contribute to more optimal physiological balance and oxidative metabolism.

Units per container: about 30
Unit size: 20 drops
Each unit contains the following ingredients:

Adamantane: 33mg

Other ingredients: tocopherols, MCT
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[Atman]

Let's solve the depression epidemic by taking substances which manipulates our neurochemistry, because mechanistic materialism in medicine has got us so far!

 

[nasibi]

Thanks!

 

[haidut]

A novel therapeutic approach to depression via supplement with tyrosine hydroxylase

Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. The regulated activity of TH is thought to play a critical role in modulating the functional activity of catecholaminergic neuronal systems in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression. Here we showed that TH, delivered by protein transduction domain (PTD), passed through the blood–brain barrier and entered the neurons. Systemic TH treatment improved the behavioral despair in the forced swim test (FST) and the tail suspension test (TST), the two models widely used to screen the potential anti-depressant efficacy. The results indicated a novel and potential therapeutic use of TH in the depression disorder.

Haidut, any thoughts on bringing this out as a product for research/lab purposes on our mice?

Vitamin B6 is a cofactor for that enzyme, so supplying a combination of BCAA/tyrosine and B6, as well as getting exposed to light should do the trick. No need for a separate supplement IMO.