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metabolism
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Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)
The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...- haidut
- Thread
- deficiency energy mitochondria parkinson pd ros
- Replies: 25
- Forum: Scientific Studies
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Inhibiting respiration/metabolism reliably causes bipolar disorder
Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...- haidut
- Thread
- bipolar disorder depression etc mania mitochondria oxphos
- Replies: 0
- Forum: Scientific Studies
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Glucose + vitamin B3 combo synergistic for treating mitochondrial disease
A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...- haidut
- Thread
- disorder electron transport chain glucose mitochondria niacinamide synergy vitamin b3
- Replies: 11
- Forum: Scientific Studies
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Boosting metabolism causes huge stress reaction in very well fed body
I'm eating 400-500g of sugar and 200-250g of protein every day. Around 3000 kcal daily. All good quality, Peaty foods. Oranges, raisins, milk, cheese, organ meats. I'm eating every hour or so. Yet I can't handle even the slightest metabolic boost. 100mg of caffeine, 50mg of niacinamide, 150mg...- BearWithMe
- Thread
- caffeine stress reaction thyroid
- Replies: 31
- Forum: Ask For Help or Advice
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PUFA promote torpor / hibernation, decrease lifespan
Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly...- haidut
- Thread
- coq10 hibernation omega-3 omega-6 pufa temperature torpor
- Replies: 10
- Forum: Scientific Studies
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Blocking PUFA/prostaglandins restores metabolism and reverses brain aging
The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...- haidut
- Thread
- aging aspirin brain glucose inflammation prostaglandins pufa
- Replies: 5
- Forum: Scientific Studies
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Should friendship be forced? How exactly does "friendship" or "having friends" work across different parameters?
I have noticed some people just always have friends, and they don't do anything special or specific to make or keep them. Sometimes it's just neighborhood kids, workplace, schools, etc. -- and often it just naturally happens. I find it disheartening that some say that "making" or "finding"...- MetabolicTrash
- Thread
- friends friendship health lifestyle upbringing
- Replies: 14
- Forum: Ask For Help or Advice
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Rat smarter with pullover / rat hats
Hello friends of metabolic health Georgi @haidut mentions a study in a danny roddy podcast (iirc) that rats with beanies or a sweater are more intelligent/ solve a rat labyrinth faster. I am now searching this for like a week, and i can not find it. IF PLEASE SOMEONE CAN TELL ME WHERE I CAN... -
Recommendations for Books on Evolution of Metabolism
Hello! Im interested in the evolution of metabolic processes. I have found academic books which are focused on the very minute, but nothing that would be useful to me. Does anyone have any recommendations? I was looking at Nick Lane's vital question. Mae-Won Ho? Gerald Pollack? Ling? I am...- rothko
- Thread
- books danny roddy haidut ray peat
- Replies: 1
- Forum: Metabolism
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Reduced pyruvate and/or increased lactate drive heart failure
I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...- haidut
- Thread
- energy heart failure lactate lactic acid oxphos pyruvate
- Replies: 0
- Forum: Scientific Studies
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Low energy production (glucose metabolism) may cause andropause
As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...- haidut
- Thread
- aging andropause energy glucose hypogonadism steroidogenesis testosterone
- Replies: 0
- Forum: Scientific Studies
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The Cure For Aging Might Be The Cure For Alzheimer’s
Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure...- haidut
- Thread
- aging alzheimer cure disease energy immortality
- Replies: 3
- Forum: Scientific Studies
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Low, Not High, Metabolism Creates Oxidative Stress
A hugely popular tenet of the "rate of living" theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental...- haidut
- Thread
- electron acceptor oxidation oxidative stress oxphos redox reduction ros
- Replies: 6
- Forum: Scientific Studies
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Red Light Therapy For Parkinson Disease (PD) Begins Human Trials
A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...- haidut
- Thread
- cytochrome c energy human mitochondria parkinson red light
- Replies: 2
- Forum: Scientific Studies
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J
Eating Liver Makes Me Feel Cold More Often And Faster, Why?
On a low A diet I have less energy, can't sleep, have oily and worse skin, but my temps are higher between meals. I found I have to eat liver daily. I get great energy from it, sleep perfectly and have much better skin. But I always find it makes my temps drop faster between meals. Is this...- julcreutz
- Thread
- cold cold hands and feet energy liver low a low vitamin a retinol thyroid
- Replies: 7
- Forum: Metabolism
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Progesterone - Not A Sex Hormone, But A Systemic Health Hormone
An older study, but some great information in there. Not only does it call attention to the fallacy of progesterone being nothing more than a "sex" hormone, but it also warns about the fallacy of equating the synthetic progestins with bioidentical progesterone. At least, when it comes to...- haidut
- Thread
- blood pressure brain calcium cvd health progesterone systemic
- Replies: 61
- Forum: Scientific Studies
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Ehlers-Danlos Syndrome Help?
Hi all, I recently posted a thread here: (Feeling Terrible at 22) where I basically listed all my symptoms and recieved some amazing advice for my metabolism, overall dietary health etc. I suggest reading this post first to get an insight into my lifestyle and health. (TL-DR; I basically...- JazTee
- Thread
- arthritis chronic pain collagen eds ehlers-danlos syndrome fatigue health joints pain
- Replies: 6
- Forum: Ask For Help or Advice
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Ultrasound Therapy Device?
Anybody have a good source for a personal Ultrasound Therapy Device? I have a minor bone bruise that I want to give one a shot on.- Scott Andrew
- Thread
- bone bone healing bruise calcium red light therapy ultrasound vitamin d
- Replies: 0
- Forum: Metabolism
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Fat Loss, PUFA, Estrogen Detox And Increased Metabolism
So dear all - questions questions questions....theories theories theories....don't we all just love em!!! Would really appreciate any help and input here from any and all who find the topics around Peat, Fat gain, and metabolism interesting. A bit of background. I come from a varied past of...- Re.Generate
- Thread
- aspirin detox estrogen fat gain fat loss pufa
- Replies: 0
- Forum: Weight
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Low Metabolism, Cellular Debris May Cause Huntington Disease (HD)
Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular...- haidut
- Thread
- debris huntington inflammation mitochondria oxphos stress thiamine
- Replies: 0
- Forum: Scientific Studies