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- Jan 12, 2014
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I've suffered from depression for a very long time. I still trying to figure out an answer. I've tried cyproheptadine (periactin) after reading that it can lower serotonin and can be effective in treating depression. However, I haven't really noticed any improvement. My doctor has recommended that I try amitriptyline, a drug that has been around since the 1950's. Everything I read says that it works similiarly to serotonin inhibitors, increasing serotonin in the brain to "promote positive feelings." But I am confused because I read that it is in the same family as cyproheptadine, a drug that is supposed to reduce serotonin. They are both chemical compounds with the tryclic structure.
"In recent times, the TCAs have been largely replaced in clinical use in most parts of the world by newer antidepressants which typically have more favorable side-effects profiles such as the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and the norepinephrine reuptake inhibitors (NRIs) like reboxetine, though they are still sometimes prescribed for certain indications."
In addition, I asked Ray if he thought this drug is safe and he said the following:
Me:
Hi Dr. Peat,
I wanted to know if amitriptyline would be a safe option for treating depression/anxiety in your opinion. My doctor is recommending that I take it.
Thanks.
Ray:
I think it's safe. Compare the structure with cyproheptadine. Have you tried niacinamide, pregnenolone, and thyroid?
Me:
I currently take cyproheptadine. From my understanding, amitriptyline and cyproheptadine have opposing effects on serotonin. Is this true, and could this be problematic, if so?
Thanks.
Ray:
Both of those are appetite stimulants that tend to cause weight gain. Serotonin tends to cause anorexia. The drug industry generates noise in the process of selling drugs, and "serotonin" is one of their favorite noises.
What is the deal with this drug? Is all the crap I read on the internet B.S. Why would ray say it's "safe" it is increases serotonin? I'm losing my mind here, and I don't know what to make of all this. Any advice or insight would be greatly appreciated. Thank you in advance.
"In recent times, the TCAs have been largely replaced in clinical use in most parts of the world by newer antidepressants which typically have more favorable side-effects profiles such as the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and the norepinephrine reuptake inhibitors (NRIs) like reboxetine, though they are still sometimes prescribed for certain indications."
In addition, I asked Ray if he thought this drug is safe and he said the following:
Me:
Hi Dr. Peat,
I wanted to know if amitriptyline would be a safe option for treating depression/anxiety in your opinion. My doctor is recommending that I take it.
Thanks.
Ray:
I think it's safe. Compare the structure with cyproheptadine. Have you tried niacinamide, pregnenolone, and thyroid?
Me:
I currently take cyproheptadine. From my understanding, amitriptyline and cyproheptadine have opposing effects on serotonin. Is this true, and could this be problematic, if so?
Thanks.
Ray:
Both of those are appetite stimulants that tend to cause weight gain. Serotonin tends to cause anorexia. The drug industry generates noise in the process of selling drugs, and "serotonin" is one of their favorite noises.
What is the deal with this drug? Is all the crap I read on the internet B.S. Why would ray say it's "safe" it is increases serotonin? I'm losing my mind here, and I don't know what to make of all this. Any advice or insight would be greatly appreciated. Thank you in advance.