Cardenosine - Liquid Product For R&D

[haidut]

My Cardenosine arrived with some precipitate--is it stable enough to heat it briefly to try to dissolve it or how might I proceed?

Yes, you can heat it up a bit. Nothing in it will spoil due to heat unless you boil it for like 15min.

 

[haidut]

can you explain this a little further, why is ATP anti serotonin?

I posted a thread on this. A metabolite of inosine powerfully lowered serotonin in humans.
Inosine As A Powerful Inhibitor Of Serotonin And Cortisol Synthesis

ATP and other purines have been shown to increase dopamine and dopamine inhibits the enzyme TPH which synthesizes serotonin.
Dopamine and dopamine agonists inhibit serotonin synthesis

 

[haidut]

Is there a link between pyroglutamic acid and higher HGH?

Not that I am aware of, so it you find something please post here.

 

[Pointless]

4/6/18: I've had little success raising my metabolism with thyroid hormone, caffeine, quinones, even after years of Peating. I've had the most success cycling them over 3 days, but today I woke up with temp of 96.3. I decided to change things up. Took 1 drop of Oxidal and 20 drops of Cardenosine orally. Experienced signs of dramatically increased metabolism and lowered estrogen:
Loss of water
Skin was described as "soft and supple" by someone else
Increased libido
Energetic like I took caffeine

These eventually tapered off, but my average afternoon temp increased from 97.6 to 98.1. My morning temps increased from 96.2-96.5 to 97.0. There's nothing else that can consistently do this! I also feel warmer than usual

Pulse measured at 83 and blood pressure at 109/66, which is typical.

With Oxidal comes side effects:
Gut inflammation (pain in abdomen and loose stools)
Skin redness, itchiness
Spacing out
Headaches
Deep cough

Some of these seemed less than solo Oxidal, but it's hard to tell. They eventually went away mostly. But taking 2 drops of Oxidal per day will make them come back even worse. My gut seems to be pretty sensitive to Oxidal, perhaps because of its anti-pathogen properties.

Cardenosine side effect was paresthesia, 0-2x/day. I never noticed this with 40 drops once every 3 days.

Also, I've felt less catatonic emotionally. It's not like a wild, uninhibited, super high libido feeling like ergot derivatives. It's like feeling more human.

 

[haidut]

4/6/18: I've had little success raising my metabolism with thyroid hormone, caffeine, quinones, even after years of Peating. I've had the most success cycling them over 3 days, but today I woke up with temp of 96.3. I decided to change things up. Took 1 drop of Oxidal and 20 drops of Cardenosine orally. Experienced signs of dramatically increased metabolism and lowered estrogen:
Loss of water
Skin was described as "soft and supple" by someone else
Increased libido
Energetic like I took caffeine

These eventually tapered off, but my average afternoon temp increased from 97.6 to 98.1. My morning temps increased from 96.2-96.5 to 97.0. There's nothing else that can consistently do this! I also feel warmer than usual

Pulse measured at 83 and blood pressure at 109/66, which is typical.

With Oxidal comes side effects:
Gut inflammation (pain in abdomen and loose stools)
Skin redness, itchiness
Spacing out
Headaches
Deep cough

Some of these seemed less than solo Oxidal, but it's hard to tell. They eventually went away mostly. But taking 2 drops of Oxidal per day will make them come back even worse. My gut seems to be pretty sensitive to Oxidal, perhaps because of its anti-pathogen properties.

Cardenosine side effect was paresthesia, 0-2x/day. I never noticed this with 40 drops once every 3 days.

Also, I've felt less catatonic emotionally. It's not like a wild, uninhibited, super high libido feeling like ergot derivatives. It's like feeling more human.

Amazing, thanks for the feedback! Keep in mind that methylene blue can raise serotonin in some people even at lower doses. So, maybe even a single drop is enough when combining with Cardenosine in order to avoid these side effects on GI, skin and head.

 

[T-3]

I'm happy to hear the good effects you report. Cardenosine makes me pleasantly warm; I feel serotonin effects lifting in a way that I've never felt so palpably with other supps; emotional calm + alertness and de-stressing sensation in the abdominal region all make Cardenosine a uniquely special tool in the toolkit. And yes, for me, it relieves acute hangover symptoms as promised.

Your comment about Oxidol/MB even at higher doses not causing urine discoloration rings true for me, too. For those of us that can go up to 20 or more drops of Oxidol per day for several days (with adamatane or without) WITHOUT seeing any urine discoloration anywhere, what can that mean? I'd be grateful if Haidut and others might share thoughts on what lack of discoloration in urine w/ MB supplementation might mean. Is the answer that my body requires even more?:) [Brief history: came to RPF with broken metabolism after 10+ years or extreme carb restriction, which I THOUGHT had worked well for 5 years or more. Thanks to info and IL rat experiment insights, my metabolic function has radically improved over last two years (weight is where I want it, all the inflammation symptoms of aging that were rapidly coming on 3-4 years ago have faded; energy levels good). Now I'm in fairly stable state with T3/NDT/Oxidal/Energin + cycling through decouplers every now and then for more CO2 alao Vision Of Strength but without CO2 tanks + capnet]

I've been taking Cardenosine for almost 2 weeks now, 40 drops every other day + 2 drops Oxidal. (Sidenote: I have been taking 2 tablets of Cynomel daily, divided into 4 doses of 1/2 tablet, since 2010. I tried all different adjustments to my diet etc. and for some reason this is the amount I need to function and keep my temps/pulse up. I was exposed to mold and insecticides on and off for the last 4 or so years, which impacted me further. I strongly suspect that my sister and I inherited some mitochondrial thing from my mother since we all have strong symptoms, even since childhood.) Effects: absence of quicksand-like fatigue, mental clarity/general cognitive improvement, emotional/mental lift, increased endurance/muscle weakness seems to be going away, increased appetite (I was only eating 2 small/med meals & 2 snacks per day, until I woke up ravenous at 3am a few nights ago, now I need 3 more substantial meals), premenstrual symptoms associated with estrogen were almost gone - fibrocystic sore breasts, super-heavy period sometimes lasting 2 weeks, irregular etc (I'm turning 51 next month, and perimenopausal), better digestion (had IBS-like symptoms, bloating, gas, diarrhea + slow transit, intolerant of milk proteins), my thumb nails that I had been unable to grow since 2014 due to vertical splitting are beginning to grow out finally. Facial puffiness is going away. Will report on my progress again soon.

Edit: By the way, I experimented with 13mg doses of methylene blue a little over a year ago, and even at that dose, my pee was at best, green. Never blue.

 

[Fractality]

I have purchased this for a research study of mine. Was the dosing meant to replicate dosing used in the referenced studies? For instance the dosing in this study (Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. - PubMed - NCBI) was intravenous. Can that be expected to be replicated via topical adminstration?

 

[haidut]

I have purchased this for a research study of mine. Was the dosing meant to replicate dosing used in the referenced studies? For instance the dosing in this study (Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. - PubMed - NCBI) was intravenous. Can that be expected to be replicated via topical adminstration?

Metadoxine uses regular pyridoxine Hcl in a 1:1 (molar) ratio with pyroglutamic acid. So, most human studies used 300mg - 600mg Metadoxine daily, which would equate to about 130mg - 260mg pyroglutamic acid daily. Thus, the 300mg dose in Cardenosine should be enough to replicate the study design.

 

[Koveras]

Our new product is finally here and it is "all about the ATP". I mentioned quite a few times on the forum and over email that we plan on releasing an ATP product and people have been asking me about it for the last few months. It seems a very simple task at first but we thought that we can do a bit better than just release a plain ATP supplement. So, without further ago here is what it contains and why.

Adenosine Triphosphate (ATP) is the cardinal adsorbent in Gilbert Ling's theory of the cell. While mainstream medicine claims that the data on oral administration of ATP is inconclusive, there are several human studies showing that oral ATP is absorbed and has several beneficial effects on muscle health. In addition, an animal study in the references section below shows striking reduction of tumor growth, reversal of cachexia and mortality in animals administered ATP. While tumor are known to produce ATP in amounts similar to normal cells, they do it through glycolysis. So, providing exogenous ATP seems to reduce the excessive glycolysis, lactic acid buildup, and thus the breakdown of tissues (cachexia) in order to feed the tumor. This suggests (once again) that tumor cells are not evil but simply cells under a lot of stress, and reduction of this stress through the provision of beneficial chemicals is therapeutic. So, I think the addition of ATP to Cardenosine does not really need much justification given it is billed as a pro-ATP product.

As a testament to the importance of ATP in every cell and especially cells highly sensitive to energy deprivation, recent human clinical trials found that increasing ATP levels in the scalp promotes hair growth in male androgenic alopecia, also known as male pattern baldness (MPB). Hair follicles are among the cellular systems most sensitive to ATP depletion, perhaps second only to the brain. The human trials actually used a saturated fatty acid called pentadecanoic acid topically on the scalp and found that the effectiveness of that fatty acid in restoring hair growth was due to its effects on raising scalp levels of succinic acid, and succinic acid then dramatically increased ATP levels. This is not surprising as succinic acid is a very efficient precursor of ATP. So, by using Cardenosine on the scalp, it may be able to deliver ATP directly to those hair follicles and restore hair growth. Cardenosine also contains succinic acid, for an additional ATP boost, and even if there are some doubts about transdermal ATP absorption effectiveness it has been confirmed numerous times (in animals and humans) that succinic acid absorbs through the skin.

http://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.1993.tb00592.x/abstract
"...The effect of the glyceride of pentadecanoic acid (PDG) in treating male pattern alopecia has already been confirmed in a double blind controlled clinical test. In order to study the mechanism of the hair growing effect of PDG, ATP levels were measured in the hair follicles of rabbits. The ATP levels in telogen hair follicles increased remarkably with the application of PDG. To examine this effect, the metabolic properties of pentadecanoic acid (PDA) were investigated using the mitochondrial fraction prepared from guinea-pig hair follicles. It was shown that PDA could be metabolized in hair follicles, and succinic acid, which was formed in the degradation process of PDA, had a remarkable ATP producing ability. These results suggest that the hair growing effect of PDG depends on the efficient supply of energy to hair follicles, and this mechanism seems to be derived from the metabolic property of the odd numbered carbon fatty acid, PDA."

Based on the above study, pentadecanoic acid (another SFA) is now approved in Japan as topical treatment for hair loss.
Clinical Evaluation of The Product Containing Glyceride of Pentadecanoic Acid on Male Pattern Alopecia in Women

A combination of SolBan + Cardenosine (SolBan - Liquid Aspirin/Caffeine/Niacinamide Mix) may be even more beneficial due to the additional antiinflammatory and antifibrotic effects of caffeine, niacinamide, aspirin, inosine, B6, etc.

But I am jumping the gun here, so let's get back to the story on how I got around to releasing Cardenosine. About a year ago I stumbled upon a product sold in Europe and Latin America as an anti-alcohol and liver health remedy. The product is known as Metadoxine, and it is a simple combination of L-pyroglutamic acid (L-PGA) and vitamin B6 (pyridoxine Hcl).
Metadoxine - Wikipedia
As a side note, despite its (unfortunate) common name suggesting it is a variation of glutamic acid, L-PGA is actually just an oxidized version of the amino acid proline (which Peat has written many times about comparing it to glycine). The chemical name of L-PGA is 5-oxo-proline (5-keto-proline) and its properties are much more similar to proline than to glutamic acid. In fact, L-PGA has been shown to act as a glutamate antagonist, at least in the brain.
The main effect of Metadoxine, observed across many human and animal studies, is to accelerate alcohol metabolism (by speeding up BOTH alcohol dehydrogenase and aldehyde dehydrogenase) and reduce the negative effects of acetaldehyde on the entire organism. While initially it was thought that increase of activity in the alcohol metabolizing enzymes was the main mechanism of action for Metadoxine, more recent studies discovered that the chemical also prevents the depletion of ATP that alcohol consumption induces. This prevention of ATP depletion is likely at least as important for the observed benefits of Metadoxine, as speeding up the activity of the alcohol-metabolizing enzymes.

"...Metadoxine is an ion pair salt of pyridoxine and pyrrolidon carboxilate (PCA).[1] Pyridoxine (vitamin B6) is a precursor of coenzymes including pyridoxal 5’-phosphate (PLP), which accelerates the metabolic degradation of ethanol and prevents adenosine triphosphate (ATP) inactivation by acetaldehyde. Pyridoxal phosphate dependent enzymes also play a role in the biosynthesis of four important neurotransmitters: serotonin (5-HT), epinephrine, norepinephrine and GABA: see vitamin B6 functions. L-PGA is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids. In the central nervous system (CNS), L-PGA was found to have a role in composition of neuro-active molecules. Its production has been linked to hepatic gamma-glutamyl transferase activity and levels of reduced glutathione (GSH). Lastly, it was shown that L-PGA facilitates ATP synthesis by stimulating de novo synthesis of purines."

And since the metabolism of alcohol requires ATP, the current theory is that Metadoxine exerts most of its protective effects on the liver by preventing the decline of ATP when alcohol is consumed. This makes sense and matches the recent posts about inosine ameliorating fatty liver by raising levels of ATP. Furthermore, other studies found that Metadoxine (or more specifically its component L-PGA) increases de novo synthesis of ATP from purines (e.g. inosine) and thus prevents ATP depletion systemically as a result of other toxic assaults including carcinogens, radiation, and various chronic conditions. So, all in all, the combination of L-PGA and vitamin B6 has been shown to prevent ATP depletion from a number of assaults that organisms encounter every day.
As if that was not good enough, Metadoxine is known as serotonin antagonist at the 5-HT2B receptor. This second effect is probably why it has shown beneficial results for liver fibrosis, secondary to alcohol consumption. Studies that have tried to elucidate the mechanism of antagonism point to L-PGA as the most likely active ingredient.
5-HT2B receptor - Wikipedia
"....Metadoxine: a 5ht2b antagonist and GABA-activity modulator [33]"

As you can see from the Wikipedia pages, Metadoxine is currently being evaluated for ADHD - a condition associated with dopamine deficiency and currently treated with dopaminergic stimulants like Ritalin and Adderall. Furthermore, studies are being conducted with Metadoxine for Fragile X syndrome, which is a subset of autism thought to be genetically driven. Given the role of dopamine deficiency in ADHD and serotonin excess (i.e. hence dopamine deficiency as well) in autism, I did some digging and it turns out that Metadoxine does indeed raise dopamine and lower serotonin (see study in the references section). Thus, the rational for including the ingredients of Metadoxine in our product are the prevention of ATP depletion by various assaults as well as its anti-serotonin and pro-dopamine effects.

Now, given that Metadoxine raises ATP levels by accelerating de-novo purine synthesis as well as the purine salvage pathway,its effects will be even more pronounced if there was enough raw material for ATP synthesis floating around. One such raw material is of course inosine, and that is why the product includes inosine as another ingredient. In addition to the studies I posted on inosine ameliorating fatty liver. I also posted about the ability of inosine to raise the NAD/NADH ratio, as well as increase mitochondrial biogenesis, oxidative respiration, and lower lactate/NO/LPO. Yet another post showed that an immediate metabolite of inosine lowers both serotonin and cortisol synthesis.
Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation
Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation
Inosine As A Powerful Inhibitor Of Serotonin And Cortisol Synthesis

The benefits of inosine are numerous and it enjoys a widespread use in Europe as an immunostimulant, cardioprotector, anti-ischemic, anti-hypoxic, anti-inflammatory, anti-anemic, anabolic, and in general actoprotector substance. I collected a decent number of studies on inosine in the references section below, but these are just scratching the surface. There are thousands of studies in Russian available through various Russian-labguage databases, and I can provide additional references for those who can read in Russian or are interested in messing around with Google Translate.

While reading all those studies on inosine going back to the early 1950s, I noticed that in Europe inosine is commonly administered in combination with succinic acid. In fact, there are several patented drugs containing inosine and succinic acid, the most famous ones being Cytoflavin and Reamberin (amber acid is the common name for succinate).
Cytoflavin generic. Price of cytoflavin. Uses, Indications and Description
Reamberin - Drugs.com

Succinic acid had been studied for even longer than inosine and it has a myriad of health effects, many of them overlapping with inosine. As a Krebs cycle intermediate, its main metabolic effect is the stimulation of the Krebs cycle activity as well as the flow of electrons along the electron transport chain (ETC). In fact, the enzyme that metabolizes succinic acid (Succinic Acid Dehydrogenase) is an enzyme that is part of both the Krebs cycle and ETC. The final effects of these stimulations is of course the increase in ATP synthesis. So, the presence of succinic acid in Cardenosine is due to its role as a stimulator (and an indirect source) of ATP synthesis.

Finally, a word on potential synergy of Cardenosine with some other chemicals. Succinic acid stimulates succinic dehydrogenase and the electrons succinic acid provide subsequently flow along the ETC, assuming the ETC is working properly. However, if somebody takes succinic acid and their ETC is not functioning well for some reason then there won't be as much boost in ATP synthesis, compared to if the ETC was operating well (and the electrons from succinic acid were able to flow to O2 at the end). One way to circumvent a malfunctioning ETC is using MB (e.g. Oxidal). It provides an alternative electron acceptor for that electron flow originating from succinic acid, and it has been shown to restore electron flow along the ETC in various pathologies. And in case of well-working ETC it can speed up ATP synthesis even more than succinic acid would on its own.
Another chemical that can speed up the process of succinic acid oxidation is riboflavin (e.g. Energin) as it is the precursor of FAD, and FAD is the cofactor for succinic dehydrogenase (which metabolizes succinic acid). In fact, the drug Cytoflavin I mentioned above, contains riboflavin for that very reason. The active form of riboflavin (R5P) would work even better. However, rifoblavin/R5P/FAD will not help in case of ETC damage/malfunction. It would only speed up the Krebs cycle side of the reaction.
Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes - ScienceDirect
Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction
Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

Finally, as mentioned at the beginning of the thread, a combination of Cardenosine and SolBan may be synergistic in providing benefits to optimal hair growth. The caffeine and niacinamide present in SolBan may actually increase the transdermal absorption of the ingredients of Cardenosine and thus help deliver pre-formed ATP (from Cardenosine) directly to the hair follicles.

That's pretty much it. The idea of Cardenosine is thus very simple - increase ATP levels by exploiting various pathways. Those pathways include providing ATP directly (duh), preventing its degradation (Metadoxine), or increasing its synthesis through the Krebs cycle / ETC (succinic acid) and through the purine salvage pathway (inosine). If somebody is aware of any other pathways to ATP please let me know. Maybe @Travis can shed some light??
As far as the name Cardenosine - it is just an old and forgotten name for ATP. It is the same idea as the name Calcirol we picked for the vitamin D3 supplement.

The units listed on the label are just for measurement purposes. They do not indicate suggested or optimal dose. Please note that similar to the products sold by companies like BluePeptides, this product is for lab/research use only. The product can be ordered from the link below:
www.idealabsdc.com/lab

*******************************************************************************
Cardenosine is a product with the main purpose of raising ATP levels in an organism. Besides raising ATP, the ingredients in Cardenosine have been studies separately over a period of several decades. Those ingredients and have been found to possess a number of desirable properties - including anti-inflammatory, anti-serotonin, pro-dopamine, anti-glucocorticoid, anti-inflammatory, anti-endotoxin, anti-viral, anti-mutagenic, antimicrobial, anti-cancer, anxiolytic, antidepressant, cardioprotective, anti-ischemic, neuroprotective, and generally anti-aging.

Serving size: 40 drops
Servings per container: about 15
Each serving contains the following ingredients:

Adenosine Triphosphate (ATP): 200mg
L-Pyroglutamic acid: 300mg
Vitamin B6 (P5P): 10mg
Succinic acid: 200mg
Inosine: 50mg

Other ingredients: distilled water
*******************************************************************************

References:

ATP:
Anticancer activities of adenine nucleotides in tumor bearing hosts (very important!)
http://jpet.aspetjournals.org/content/jpet/294/1/126.full.pdf
A Single Dose Of Oral Atp Supplementation Improves Performance And Physiological Response During Lower Body Resistance Exercise In Recreational Res... - PubMed - NCBI
Oral Adenosine-5'-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Re... - PubMed - NCBI
Treatment with Oral ATP decreases alternating hemiplegia of childhood with de novo ATP1A3 Mutation. - PubMed - NCBI
Oral adenosine-5'-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. - PubMed - NCBI
Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. - PubMed - NCBI
Cardiovascular and pulmonary response to oral administration of ATP in rabbits. - PubMed - NCBI


L-Pyroglutamic acid:

1. Misc
[Reproductive toxicity of metadoxine in rats]. - PubMed - NCBI
Brain penetration of orally administered sodium pyroglutamate. - PubMed - NCBI
Neurotoxic effects of endogenous materials: quinolinic acid, L-pyroglutamic acid, and thyroid releasing hormone (TRH). - PubMed - NCBI
[Metadoxine in the treatment of vomiting in uremic patients under dialysis treatment]. - PubMed - NCBI
Pyroglutamate kinetics and neurotoxicity studies in mice. - PubMed - NCBI


2. Anti-cancer
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. - PubMed - NCBI


3. Insulin resistance / diabetes
Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice. - PubMed - NCBI
Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA... - PubMed - NCBI


4. Vision / eyes / retina
Pyroglutamic acid promotes survival of retinal ganglion cells after optic nerve injury. - PubMed - NCBI
Reduction of enhanced rabbit intraocular pressure by instillation of pyroglutamic acid eye drops. - PubMed - NCBI


5. Pro-dopamine / anti-prolactin
Effect of metadoxine on striatal dopamine levels in C57 black mice. - PubMed - NCBI
Isolation of pyroglutamic acid from hypothalamic tissue and significance of its inhibition of prolactin release. - PubMed - NCBI


6. Mood / Mental Health / Cognition
Pyroglutamic acid improves the age associated memory impairment. - PubMed - NCBI
A randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy, safety, and tolerability of extended-release metadoxine ... - PubMed - NCBI
Alternative pharmacological strategies for adult ADHD treatment: a systematic review. - PubMed - NCBI
Attention benefits after a single dose of metadoxine extended release in adults with predominantly inattentive ADHD. - PubMed - NCBI
Efficacy of metadoxine extended release in patients with predominantly inattentive subtype attention-deficit/hyperactivity disorder. - PubMed - NCBI
Capillary electrophoresis for caffeine and pyroglutamate determination in coffees study of the in vivo effect on learning and locomotor activity in... - PubMed - NCBI
Pyroglutamic acid improves learning and memory capacities in old rats. - PubMed - NCBI


7. Neuroprotective
[The central vascular and metabolic effects of pyroglutamic acid]. - PubMed - NCBI
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice. - PubMed - NCBI
[Molecular mechanisms of pidolate magnesium action and its neurotropic affects]. - PubMed - NCBI
Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery. - PubMed - NCBI
[Correlations of pharmacokinetics and pharmacodynamics of a combined preparation containing pyrrolidone and pyroglutamic acid]. - PubMed - NCBI
Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier. - PubMed - NCBI
[Neuroprotective and cerebrovascular effects of GABA mimetics]. - PubMed - NCBI
[Evolution of the neuroprotection concept]. - PubMed - NCBI
[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone]. - PubMed - NCBI
[Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation]. - PubMed - NCBI
L-pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury. - PubMed - NCBI
Role of oxoproline in the regulation of neutral amino acid transport across the blood-brain barrier. - PubMed - NCBI
Investigations on the binding properties of the nootropic agent pyroglutamic acid. - PubMed - NCBI
Pyroglutamic acid administration modifies the electrocorticogram and increases the release of acetylcholine and GABA from the guinea-pig cerebral c... - PubMed - NCBI
Is glutamate a trigger factor in epileptic hyperactivity? - PubMed - NCBI


8. Anti-alcohol / liver health / hepatitis
Pyroglutamic acid stimulates DNA synthesis in rat primary hepatocytes through the mitogen-activated protein kinase pathway. - PubMed - NCBI
Identification of a hepatoprotective peptide in wheat gluten hydrolysate against D-galactosamine-induced acute hepatitis in rats. - PubMed - NCBI
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. - PubMed - NCBI
Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial. - PubMed - NCBI
Treatment with metadoxine and its impact on early mortality in patients with severe alcoholic hepatitis. - PubMed - NCBI
Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. - PubMed - NCBI
[Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study]. - PubMed - NCBI
Acute alcohol intoxication. - PubMed - NCBI
Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK... - PubMed - NCBI
A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence. - PubMed - NCBI
[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]. - PubMed - NCBI
Metadoxine in the treatment of acute and chronic alcoholism: a review. - PubMed - NCBI
Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine. - PubMed - NCBI
Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. - PubMed - NCBI
Efficacy of metadoxine in the management of acute alcohol intoxication. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/11712874
https://www.ncbi.nlm.nih.gov/pubmed/10207820
https://www.ncbi.nlm.nih.gov/pubmed/9675549
https://www.ncbi.nlm.nih.gov/pubmed/9537864
https://www.ncbi.nlm.nih.gov/pubmed/8839633
https://www.ncbi.nlm.nih.gov/pubmed/8867649
https://www.ncbi.nlm.nih.gov/pubmed/7512265
https://www.ncbi.nlm.nih.gov/pubmed/8482064
https://www.ncbi.nlm.nih.gov/pubmed/8088945
https://www.ncbi.nlm.nih.gov/pubmed/1476554
https://www.ncbi.nlm.nih.gov/pubmed/1568369
https://www.ncbi.nlm.nih.gov/pubmed/1310810
https://www.ncbi.nlm.nih.gov/pubmed/1870355
https://www.ncbi.nlm.nih.gov/pubmed/1678735
https://www.ncbi.nlm.nih.gov/pubmed/2529084
https://www.ncbi.nlm.nih.gov/pubmed/2972505
https://www.ncbi.nlm.nih.gov/pubmed/3828134
https://www.ncbi.nlm.nih.gov/pubmed/3539468
https://www.ncbi.nlm.nih.gov/pubmed/7192694


Succinic Acid:

1. Misc.
https://www.ncbi.nlm.nih.gov/pubmed/14968174
https://www.ncbi.nlm.nih.gov/pubmed/27141637
https://www.ncbi.nlm.nih.gov/pubmed/25076754
https://www.ncbi.nlm.nih.gov/pubmed/24555229
https://www.ncbi.nlm.nih.gov/pubmed/25790698
https://www.ncbi.nlm.nih.gov/pubmed/23457968
https://www.ncbi.nlm.nih.gov/pubmed/27502960
https://www.ncbi.nlm.nih.gov/pubmed/27072777
https://www.ncbi.nlm.nih.gov/pubmed/28974722
https://www.ncbi.nlm.nih.gov/pubmed/14816255
https://www.ncbi.nlm.nih.gov/pubmed/14137425
https://www.ncbi.nlm.nih.gov/pubmed/3756230
https://www.ncbi.nlm.nih.gov/pubmed/23901465

2. Cancer
https://www.ncbi.nlm.nih.gov/pubmed/29412795
https://www.ncbi.nlm.nih.gov/pubmed/16746008


3. Reproductive/menopause
https://www.ncbi.nlm.nih.gov/pubmed/23767097
https://www.ncbi.nlm.nih.gov/pubmed/23323329
https://www.ncbi.nlm.nih.gov/pubmed/27759458


4. ATP/Metabolism/insulin/diabetes/obesity
https://www.ncbi.nlm.nih.gov/pubmed/29211771
https://www.ncbi.nlm.nih.gov/pubmed/11109530
https://www.ncbi.nlm.nih.gov/pubmed/10965352
https://www.ncbi.nlm.nih.gov/pubmed/9580367
https://www.ncbi.nlm.nih.gov/pubmed/8865105
https://www.ncbi.nlm.nih.gov/pubmed/7857680
https://www.ncbi.nlm.nih.gov/pubmed/3202180
https://www.ncbi.nlm.nih.gov/pubmed/3571215
https://www.ncbi.nlm.nih.gov/pubmed/3032929
https://www.ncbi.nlm.nih.gov/pubmed/16315979
https://www.ncbi.nlm.nih.gov/pubmed/17537413
https://www.ncbi.nlm.nih.gov/pubmed/16910316
https://www.ncbi.nlm.nih.gov/pubmed/16694665
https://www.ncbi.nlm.nih.gov/pubmed/13525390
https://www.ncbi.nlm.nih.gov/pubmed/13242564
https://www.ncbi.nlm.nih.gov/pubmed/13898070
https://www.ncbi.nlm.nih.gov/pubmed/7181923
https://www.ncbi.nlm.nih.gov/pubmed/6289887
https://www.ncbi.nlm.nih.gov/pubmed/7269512


5. GI/liver/digestion/endotoxin/Kidney
https://www.ncbi.nlm.nih.gov/pubmed/9178284
https://www.ncbi.nlm.nih.gov/pubmed/7944393
https://www.ncbi.nlm.nih.gov/pubmed/15856914
https://www.ncbi.nlm.nih.gov/pubmed/17855829
https://www.ncbi.nlm.nih.gov/pubmed/18649657
https://www.ncbi.nlm.nih.gov/pubmed/18055880
https://www.ncbi.nlm.nih.gov/pubmed/23536947
https://www.ncbi.nlm.nih.gov/pubmed/21516854
https://www.ncbi.nlm.nih.gov/pubmed/20919557
https://www.ncbi.nlm.nih.gov/pubmed/19529856
https://www.ncbi.nlm.nih.gov/pubmed/27411015
https://www.ncbi.nlm.nih.gov/pubmed/27030185
https://www.ncbi.nlm.nih.gov/pubmed/26118088
https://www.ncbi.nlm.nih.gov/pubmed/14771029
https://www.ncbi.nlm.nih.gov/pubmed/7256925
https://www.ncbi.nlm.nih.gov/pubmed/7364086
https://www.ncbi.nlm.nih.gov/pubmed/44392
https://www.ncbi.nlm.nih.gov/pubmed/730417


6. Neuroprotective/CNS
https://www.ncbi.nlm.nih.gov/pubmed/15206559
https://www.ncbi.nlm.nih.gov/pubmed/12910308
https://www.ncbi.nlm.nih.gov/pubmed/12230956
https://www.ncbi.nlm.nih.gov/pubmed/9027260
https://www.ncbi.nlm.nih.gov/pubmed/7893078
https://www.ncbi.nlm.nih.gov/pubmed/16242831
https://www.ncbi.nlm.nih.gov/pubmed/15565840
https://www.ncbi.nlm.nih.gov/pubmed/17523453
https://www.ncbi.nlm.nih.gov/pubmed/17369903
https://www.ncbi.nlm.nih.gov/pubmed/18856206
https://www.ncbi.nlm.nih.gov/pubmed/25699017
https://www.ncbi.nlm.nih.gov/pubmed/23887452
https://www.ncbi.nlm.nih.gov/pubmed/22665728
https://www.ncbi.nlm.nih.gov/pubmed/22379879
https://www.ncbi.nlm.nih.gov/pubmed/20517221
https://www.ncbi.nlm.nih.gov/pubmed/26781419
https://www.ncbi.nlm.nih.gov/pubmed/28432362
https://www.ncbi.nlm.nih.gov/pubmed/13141885
https://www.ncbi.nlm.nih.gov/pubmed/13119037
https://www.ncbi.nlm.nih.gov/pubmed/14833533
https://www.ncbi.nlm.nih.gov/pubmed/15393012
https://www.ncbi.nlm.nih.gov/pubmed/18133082
https://www.ncbi.nlm.nih.gov/pubmed/20247549
https://www.ncbi.nlm.nih.gov/pubmed/20292325


7. Stress/Mood/Cognition
https://www.ncbi.nlm.nih.gov/pubmed/3410024
https://www.ncbi.nlm.nih.gov/pubmed/14561530
https://www.ncbi.nlm.nih.gov/pubmed/26081324
https://www.ncbi.nlm.nih.gov/pubmed/26016320
https://www.ncbi.nlm.nih.gov/pubmed/25894772
https://www.ncbi.nlm.nih.gov/pubmed/13458496
https://www.ncbi.nlm.nih.gov/pubmed/13533639
https://www.ncbi.nlm.nih.gov/pubmed/13288815
https://www.ncbi.nlm.nih.gov/pubmed/1158629


8. Antibacterial/antiviral/antipathogen
https://www.ncbi.nlm.nih.gov/pubmed/28635832
https://www.ncbi.nlm.nih.gov/pubmed/14352463


9. Asthma/Allergies/histamine/inflammation/pulmonary
https://www.ncbi.nlm.nih.gov/pubmed/10227065
https://www.ncbi.nlm.nih.gov/pubmed/3325978
https://www.ncbi.nlm.nih.gov/pubmed/13010407
https://www.ncbi.nlm.nih.gov/pubmed/14926567
https://www.ncbi.nlm.nih.gov/pubmed/14868262
https://www.ncbi.nlm.nih.gov/pubmed/14852365
https://www.ncbi.nlm.nih.gov/pubmed/18870246
https://www.ncbi.nlm.nih.gov/pubmed/7375465


10. CVD/circulation/hypoxia
https://www.ncbi.nlm.nih.gov/pubmed/9607905
https://www.ncbi.nlm.nih.gov/pubmed/7819559
https://www.ncbi.nlm.nih.gov/pubmed/19145322
https://www.ncbi.nlm.nih.gov/pubmed/22866305
https://www.ncbi.nlm.nih.gov/pubmed/21846056
https://www.ncbi.nlm.nih.gov/pubmed/22420162
https://www.ncbi.nlm.nih.gov/pubmed/19803215
https://www.ncbi.nlm.nih.gov/pubmed/27475675
https://www.ncbi.nlm.nih.gov/pubmed/4670508
https://www.ncbi.nlm.nih.gov/pubmed/4076420
https://www.ncbi.nlm.nih.gov/pubmed/1023969


11. Muscle/anabolism/ergogenic/actoprotective
https://www.ncbi.nlm.nih.gov/pubmed/28944867
https://www.ncbi.nlm.nih.gov/pubmed/7773089
https://www.ncbi.nlm.nih.gov/pubmed/25016753
https://www.ncbi.nlm.nih.gov/pubmed/6498320


11. Radiation/EMF
https://www.ncbi.nlm.nih.gov/pubmed/2251365
https://www.ncbi.nlm.nih.gov/pubmed/3495507


Inosine:

1. Misc.
https://www.ncbi.nlm.nih.gov/pubmed/11912550
https://www.ncbi.nlm.nih.gov/pubmed/8940895
https://www.ncbi.nlm.nih.gov/pubmed/26903141
https://www.ncbi.nlm.nih.gov/pubmed/7079571
https://www.ncbi.nlm.nih.gov/pubmed/720586
https://www.ncbi.nlm.nih.gov/pubmed/1583701


2. Cancer
https://www.ncbi.nlm.nih.gov/pubmed/8732102
https://www.ncbi.nlm.nih.gov/pubmed/1963839
https://www.ncbi.nlm.nih.gov/pubmed/3689353
https://www.ncbi.nlm.nih.gov/pubmed/2423256


3. Reproductive/menopause
https://www.ncbi.nlm.nih.gov/pubmed/15061652
https://www.ncbi.nlm.nih.gov/pubmed/6654752


4. ATP/Metabolism/insulin/diabetes/obesity
https://www.ncbi.nlm.nih.gov/pubmed/10917906
https://www.ncbi.nlm.nih.gov/pubmed/10737175
https://www.ncbi.nlm.nih.gov/pubmed/18562629
https://www.ncbi.nlm.nih.gov/pubmed/2448739
https://www.ncbi.nlm.nih.gov/pubmed/6198929
https://www.ncbi.nlm.nih.gov/pubmed/474465
https://www.ncbi.nlm.nih.gov/pubmed/186586
https://www.ncbi.nlm.nih.gov/pubmed/186035
https://www.ncbi.nlm.nih.gov/pubmed/2650958
https://www.ncbi.nlm.nih.gov/pubmed/2601579


5. GI/liver/digestion/endotoxin/Kidney
https://www.ncbi.nlm.nih.gov/pubmed/14767733
https://www.ncbi.nlm.nih.gov/pubmed/12947007
https://www.ncbi.nlm.nih.gov/pubmed/12443716
https://www.ncbi.nlm.nih.gov/pubmed/12388199
https://www.ncbi.nlm.nih.gov/pubmed/10623851
https://www.ncbi.nlm.nih.gov/pubmed/7909375
https://www.ncbi.nlm.nih.gov/pubmed/16394918
https://www.ncbi.nlm.nih.gov/pubmed/23660094
https://www.ncbi.nlm.nih.gov/pubmed/23232950
https://www.ncbi.nlm.nih.gov/pubmed/20868668
https://www.ncbi.nlm.nih.gov/pubmed/19906119
https://www.ncbi.nlm.nih.gov/pubmed/19375788
https://www.ncbi.nlm.nih.gov/pubmed/19103461
https://www.ncbi.nlm.nih.gov/pubmed/18643723
https://www.ncbi.nlm.nih.gov/pubmed/16531145
https://www.ncbi.nlm.nih.gov/pubmed/3663162
https://www.ncbi.nlm.nih.gov/pubmed/7317735
https://www.ncbi.nlm.nih.gov/pubmed/7233650
https://www.ncbi.nlm.nih.gov/pubmed/6998075
https://www.ncbi.nlm.nih.gov/pubmed/534819
https://www.ncbi.nlm.nih.gov/pubmed/369092
https://www.ncbi.nlm.nih.gov/pubmed/55837
https://www.ncbi.nlm.nih.gov/pubmed/3188198
https://www.ncbi.nlm.nih.gov/pubmed/1350772


6. Neuroprotective/CNS
https://www.ncbi.nlm.nih.gov/pubmed/16317421
https://www.ncbi.nlm.nih.gov/pubmed/15976325
https://www.ncbi.nlm.nih.gov/pubmed/15692110
https://www.ncbi.nlm.nih.gov/pubmed/15026152
https://www.ncbi.nlm.nih.gov/pubmed/15019271
https://www.ncbi.nlm.nih.gov/pubmed/14744912
https://www.ncbi.nlm.nih.gov/pubmed/12676349
https://www.ncbi.nlm.nih.gov/pubmed/12440381
https://www.ncbi.nlm.nih.gov/pubmed/12084941
https://www.ncbi.nlm.nih.gov/pubmed/11930165
https://www.ncbi.nlm.nih.gov/pubmed/10557347
https://www.ncbi.nlm.nih.gov/pubmed/9691220
https://www.ncbi.nlm.nih.gov/pubmed/9681443
https://www.ncbi.nlm.nih.gov/pubmed/8863513
https://www.ncbi.nlm.nih.gov/pubmed/28294142
https://www.ncbi.nlm.nih.gov/pubmed/27497459
https://www.ncbi.nlm.nih.gov/pubmed/27130268
https://www.ncbi.nlm.nih.gov/pubmed/26805433
https://www.ncbi.nlm.nih.gov/pubmed/26529505
https://www.ncbi.nlm.nih.gov/pubmed/26365718
https://www.ncbi.nlm.nih.gov/pubmed/25382017
https://www.ncbi.nlm.nih.gov/pubmed/24913204
https://www.ncbi.nlm.nih.gov/pubmed/24502983
https://www.ncbi.nlm.nih.gov/pubmed/24366103
https://www.ncbi.nlm.nih.gov/pubmed/24312612
https://www.ncbi.nlm.nih.gov/pubmed/21643997
https://www.ncbi.nlm.nih.gov/pubmed/21508223
https://www.ncbi.nlm.nih.gov/pubmed/19553458
https://www.ncbi.nlm.nih.gov/pubmed/17406376
https://www.ncbi.nlm.nih.gov/pubmed/17293357
https://www.ncbi.nlm.nih.gov/pubmed/16923353
https://www.ncbi.nlm.nih.gov/pubmed/3924588
https://www.ncbi.nlm.nih.gov/pubmed/2985162
https://www.ncbi.nlm.nih.gov/pubmed/6264499
https://www.ncbi.nlm.nih.gov/pubmed/6784145
https://www.ncbi.nlm.nih.gov/pubmed/6275442
https://www.ncbi.nlm.nih.gov/pubmed/6252561
https://www.ncbi.nlm.nih.gov/pubmed/37602
https://www.ncbi.nlm.nih.gov/pubmed/286337
https://www.ncbi.nlm.nih.gov/pubmed/284422
https://www.ncbi.nlm.nih.gov/pubmed/2390879


7. Stress/Mood/Cognition
https://www.ncbi.nlm.nih.gov/pubmed/28695335
https://www.ncbi.nlm.nih.gov/pubmed/27966087
https://www.ncbi.nlm.nih.gov/pubmed/24569499
https://www.ncbi.nlm.nih.gov/pubmed/23613131
https://www.ncbi.nlm.nih.gov/pubmed/3003762


8. Immunomodulation/Antibacterial/antiviral/antipathogen
https://www.ncbi.nlm.nih.gov/pubmed/27821093
https://www.ncbi.nlm.nih.gov/pubmed/16358878
https://www.ncbi.nlm.nih.gov/pubmed/16055398
https://www.ncbi.nlm.nih.gov/pubmed/14978744
https://www.ncbi.nlm.nih.gov/pubmed/8876359
https://www.ncbi.nlm.nih.gov/pubmed/8788123
https://www.ncbi.nlm.nih.gov/pubmed/1283173
https://www.ncbi.nlm.nih.gov/pubmed/1384023
https://www.ncbi.nlm.nih.gov/pubmed/27476281
https://www.ncbi.nlm.nih.gov/pubmed/26591662
https://www.ncbi.nlm.nih.gov/pubmed/26011933
https://www.ncbi.nlm.nih.gov/pubmed/2446760
https://www.ncbi.nlm.nih.gov/pubmed/2429908
https://www.ncbi.nlm.nih.gov/pubmed/24272839
https://www.ncbi.nlm.nih.gov/pubmed/6209193
https://www.ncbi.nlm.nih.gov/pubmed/1693173
https://www.ncbi.nlm.nih.gov/pubmed/1693065
https://www.ncbi.nlm.nih.gov/pubmed/2482585
https://www.ncbi.nlm.nih.gov/pubmed/3150993
https://www.ncbi.nlm.nih.gov/pubmed/1726683


9. Asthma/Allergies/histamine/pulmonary
https://www.ncbi.nlm.nih.gov/pubmed/15579626
https://www.ncbi.nlm.nih.gov/pubmed/11923614
https://www.ncbi.nlm.nih.gov/pubmed/11712075
https://www.ncbi.nlm.nih.gov/pubmed/11673212
https://www.ncbi.nlm.nih.gov/pubmed/23355189
https://www.ncbi.nlm.nih.gov/pubmed/22456813
https://www.ncbi.nlm.nih.gov/pubmed/20472668
https://www.ncbi.nlm.nih.gov/pubmed/19174745


10. CVD/circulation/hypoxia
https://www.ncbi.nlm.nih.gov/pubmed/8240456
https://www.ncbi.nlm.nih.gov/pubmed/1462898
https://www.ncbi.nlm.nih.gov/pubmed/21059208
https://www.ncbi.nlm.nih.gov/pubmed/19902663
https://www.ncbi.nlm.nih.gov/pubmed/16730445
https://www.ncbi.nlm.nih.gov/pubmed/3503988
https://www.ncbi.nlm.nih.gov/pubmed/3830217
https://www.ncbi.nlm.nih.gov/pubmed/3737656
https://www.ncbi.nlm.nih.gov/pubmed/3956572
https://www.ncbi.nlm.nih.gov/pubmed/3591170
https://www.ncbi.nlm.nih.gov/pubmed/3922025
https://www.ncbi.nlm.nih.gov/pubmed/6705907
https://www.ncbi.nlm.nih.gov/pubmed/6347379
https://www.ncbi.nlm.nih.gov/pubmed/6888082
https://www.ncbi.nlm.nih.gov/pubmed/6847795
https://www.ncbi.nlm.nih.gov/pubmed/6368998
https://www.ncbi.nlm.nih.gov/pubmed/7094228
https://www.ncbi.nlm.nih.gov/pubmed/6889939
https://www.ncbi.nlm.nih.gov/pubmed/7326684
https://www.ncbi.nlm.nih.gov/pubmed/7449820
https://www.ncbi.nlm.nih.gov/pubmed/7423093
https://www.ncbi.nlm.nih.gov/pubmed/7377330
https://www.ncbi.nlm.nih.gov/pubmed/7224845
https://www.ncbi.nlm.nih.gov/pubmed/7370243
https://www.ncbi.nlm.nih.gov/pubmed/435683
https://www.ncbi.nlm.nih.gov/pubmed/445523
https://www.ncbi.nlm.nih.gov/pubmed/347135
https://www.ncbi.nlm.nih.gov/pubmed/910962
https://www.ncbi.nlm.nih.gov/pubmed/28559
https://www.ncbi.nlm.nih.gov/pubmed/1242314
https://www.ncbi.nlm.nih.gov/pubmed/125181
https://www.ncbi.nlm.nih.gov/pubmed/2594615
https://www.ncbi.nlm.nih.gov/pubmed/2923227
https://www.ncbi.nlm.nih.gov/pubmed/3068401
https://www.ncbi.nlm.nih.gov/pubmed/3355562
https://www.ncbi.nlm.nih.gov/pubmed/3688262
https://www.ncbi.nlm.nih.gov/pubmed/1711609
https://www.ncbi.nlm.nih.gov/pubmed/1991356


11. Muscle/anabolism/ergogenic/actoprotective
https://www.ncbi.nlm.nih.gov/pubmed/11469903
https://www.ncbi.nlm.nih.gov/pubmed/26875616
https://www.ncbi.nlm.nih.gov/pubmed/16643789


12. Radiation/EMF
https://www.ncbi.nlm.nih.gov/pubmed/19280464
https://www.ncbi.nlm.nih.gov/pubmed/17179648
https://www.ncbi.nlm.nih.gov/pubmed/16776063
https://www.ncbi.nlm.nih.gov/pubmed/16669708
https://www.ncbi.nlm.nih.gov/pubmed/2809455
https://www.ncbi.nlm.nih.gov/pubmed/2685869
https://www.ncbi.nlm.nih.gov/pubmed/1811724

Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1 month using the rat intragastric tube feeding model.

"The increase in the metabolic rate generates NAD, permitting ADH to increase the oxidation of alcohol. NAD is the rate limiting factor in oxidation of alcohol by alcohol dehydrogenase (ADH). "​

Supporting that cardenosine-energin combination

 

[miki14]

I've seen that even a mild dietary phosphorous deficiency can impair cell ATP levels. Creatine will also increase phosphate requirements and uptake - potentially a mechanism for creatine induced muscle cramps if that mild dietary phosphate deficiency is present and/or if there is insulin resistance. Important to consider, especially for athletes, considering the general emphasis on reducing phosphate intake here. ATP in this product comes with its own phosphate, but I assume ramping up ETC or utilizing the purine salvage pathways could increase phosphate requirements further.

Interesting observation. I've started a creatine supplement a few month ago with some benefits but recently I got strong muscle cramps and magnesium didn't help. I've also regained my appetite for muscle meat recently maybe I'm phospor deficient.

 

[puella]

I've had the strangest side effect. I seem to turn into this

in the eyes of one of our cats . If I put it on my forearms & he figures out it's on there he gets extremely aggressive, follows me around, and tries his best to lick it off.

Also have a human that's had consistently & stubbornly low temperatures that are rising too -using 20 drops, topically, every other day. He has had some things help, temporarily, in the past so it should be interesting to see if this is his long-term ticket. There seems to be some hair regrowth too but I think it's too soon to be certain (need to start taking pictures & document the progress). Overall happy & optimistic about our first round of cardenosine.

 

[Soren]

A combination of SolBan + Cardenosine (SolBan - Liquid Aspirin/Caffeine/Niacinamide Mix) may be even more beneficial due to the additional antiinflammatory and antifibrotic effects of caffeine, niacinamide, aspirin, inosine, B6, etc.

Finally got my Cardenosine can't wait to try it. Very curious to see what it can do for hair loss.

Ok i've got SolBan and Cardenosine. Anyone try this combo for hair loss yet? Anyone have any idea how best to combine these two for hair loss. Pour bottle of Cardenosine into my bottle SolBan? Or will they interfere/ damage each other and it is best to apply them separately? Also what ratio of cardenosine to sol ban should be used?

Sorry for so many questions. Anyone try this combo yet topically for hair loss?

 

[haidut]

I've had the strangest side effect. I seem to turn into this

in the eyes of one of our cats . If I put it on my forearms & he figures out it's on there he gets extremely aggressive, follows me around, and tries his best to lick it off.

Also have a human that's had consistently & stubbornly low temperatures that are rising too -using 20 drops, topically, every other day. He has had some things help, temporarily, in the past so it should be interesting to see if this is his long-term ticket. There seems to be some hair regrowth too but I think it's too soon to be certain (need to start taking pictures & document the progress). Overall happy & optimistic about our first round of cardenosine.

Amazing, thanks for the feedback! Lol on the cat's reaction. If he likes it and tries to lick it off then you know for sure it is good stuff. Cats are much pickier than humans and know how to avoid toxic things.

 

[haidut]

Finally got my Cardenosine can't wait to try it. Very curious to see what it can do for hair loss.

Ok i've got SolBan and Cardenosine. Anyone try this combo for hair loss yet? Anyone have any idea how best to combine these two for hair loss. Pour bottle of Cardenosine into my bottle SolBan? Or will they interfere/ damage each other and it is best to apply them separately? Also what ratio of cardenosine to sol ban should be used?

Sorry for so many questions. Anyone try this combo yet topically for hair loss?

They do not interfere with each other and should mix quite well. I would first apply the Cardenosine to the scalp and then spray SolBan on top of it. Just getting the skin covered with a very thin layer of Cardenosine should be enough. No need to soak it to the point of it dripping down your head.

 

[Soren]

They do not interfere with each other and should mix quite well. I would first apply the Cardenosine to the scalp and then spray SolBan on top of it. Just getting the skin covered with a very thin layer of Cardenosine should be enough. No need to soak it to the point of it dripping down your head.

Perfect. thanks

 

[haidut]

Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1 month using the rat intragastric tube feeding model.

"The increase in the metabolic rate generates NAD, permitting ADH to increase the oxidation of alcohol. NAD is the rate limiting factor in oxidation of alcohol by alcohol dehydrogenase (ADH). "​

Supporting that cardenosine-energin combination

Thanks. NAD is also a cofactor for acetaldehyde dehydrogenase (ALDH), so it speeds up the entire cycle of alcohol metabolism. In my experience, keeping the serotonergic effects of alcohol at bay also accelerates its metabolism. There are reports of people using adamantane and Bromantane as anti-hangover or even anti-intoxication measures, which is probably due to the dopaminergic effects and also because the adamantanes seem to be increasing cytochrome P450 expression.

 

[Soren]

Any issue with taking this combined with aspirin and k2 as hangover cure?

 

[Soren]

Any issue with taking this combined with aspirin and k2 as hangover cure?

Update. Took 30 drops of Cardenosine, 300mg of aspirin and 2mg of k2 at about 4am expecting a wicked hangover this morning. The result, nothing not even a hint of a hangover. I didn't drink an insane amount but enough that usually i'd be reaching for the pain killers right now. Very impressed.

 

[haidut]

Update. Took 30 drops of Cardenosine, 300mg of aspirin and 2mg of k2 at about 4am expecting a wicked hangover this morning. The result, nothing not even a hint of a hangover. I didn't drink an insane amount but enough that usually i'd be reaching for the pain killers right now. Very impressed.

Nice! I was about to say that even on its own Cardenosine should help, but the aspirin has anti-endotoxin effects which also help deal with hangover.

 

[managing]

is there any logic to taking a smaller dosage, but every day? So far I have found 15 drops to be plenty for amazing effects day 1.

Any reason to believe I might like 10 drops each day better? Yes, I know, experiment. Just curious if anybody has tried this?