Travis
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- Jul 14, 2016
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But it gets more complicated: fatty acids found in seeds are mostly in the form of trigylcerides, and are individually found in one of three positions along the glycerol backbone; and each position metabolized at a different rate. A trigylceride having stearic acid, palmitic acid, and myristic acid in the sn-1, sn-2, and sn-3 positions—respectively—would be metabolized a bit differently than the other combinations of same. We know enzymes of the lipid membrane are position-selective (i.e. phospholipase A₂ and phospholipase C), but metabolic enzymes can be as well. The difference between the positions is probably best demonstrated by 2-arachidonyl-
glycerol, a stripped-down tryglyceride having it's sn-1 and sn-3 positions cleaved-off leaving only an arachidonic acid ester at position sn-2. This molecule is the strongest endogenous ligand for our cannabinoid receptors, named of course for their ability to bind Cannabis phytochemicals. Since THC interferes with lipid signalling in the brain (and where arachidonic acid should be largely excluded; DPA and DHA being the preferred sn-2 lipids there), it should perhaps be no surprise that that smokers often feel the desire to eat within minutes of setting down their bongs. So not only does the concentration of fatty acids matter a great deal, it also matters a bit how they are arrayed along the glycerol backbone—enzymes and receptors actually being selective enough to discern.
So linoleic acid and γ-linolenic acid (18∶3ω−6) are also the most psychedelic fatty acids due to their exclusive ability to become arachidonic acid in the body. In a DHA or deficiency, or that of its precursor α-linolenic acid (18∶3ω−3), more arachidonic acid will be found in the brain—normally excluded by DPA and DHA. And due to the obvious psychological effects of cannabinoids and the fact that arachidonic acid is a precondition for the formation of the most powerful endocannabinoid, it would follow that ω−6-eaters are generally slower for yet another reason (besides the general antimetabolic effects and any possible immunological effects consequent of 2-series prostaglandin production). I know we had all suspected that people buying Wesson™ at the grocery store were high on something, but little did we know that it could actually have been from the vegetable oil itself (lol). So all the best science still appears to indicate that linoleic acid and γ-linolenic acid (18∶3ω−6) should prob-
ably be kept to a minimum, and small amounts of either α-linolenic acid (18∶3ω−3) or DHA actually being necessary for the brain (the only true essential fatty acids).
glycerol, a stripped-down tryglyceride having it's sn-1 and sn-3 positions cleaved-off leaving only an arachidonic acid ester at position sn-2. This molecule is the strongest endogenous ligand for our cannabinoid receptors, named of course for their ability to bind Cannabis phytochemicals. Since THC interferes with lipid signalling in the brain (and where arachidonic acid should be largely excluded; DPA and DHA being the preferred sn-2 lipids there), it should perhaps be no surprise that that smokers often feel the desire to eat within minutes of setting down their bongs. So not only does the concentration of fatty acids matter a great deal, it also matters a bit how they are arrayed along the glycerol backbone—enzymes and receptors actually being selective enough to discern.
So linoleic acid and γ-linolenic acid (18∶3ω−6) are also the most psychedelic fatty acids due to their exclusive ability to become arachidonic acid in the body. In a DHA or deficiency, or that of its precursor α-linolenic acid (18∶3ω−3), more arachidonic acid will be found in the brain—normally excluded by DPA and DHA. And due to the obvious psychological effects of cannabinoids and the fact that arachidonic acid is a precondition for the formation of the most powerful endocannabinoid, it would follow that ω−6-eaters are generally slower for yet another reason (besides the general antimetabolic effects and any possible immunological effects consequent of 2-series prostaglandin production). I know we had all suspected that people buying Wesson™ at the grocery store were high on something, but little did we know that it could actually have been from the vegetable oil itself (lol). So all the best science still appears to indicate that linoleic acid and γ-linolenic acid (18∶3ω−6) should prob-
ably be kept to a minimum, and small amounts of either α-linolenic acid (18∶3ω−3) or DHA actually being necessary for the brain (the only true essential fatty acids).
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